Imperial College London

ProfessorRobertIstepanian

Faculty of MedicineInstitute of Global Health Innovation

Visiting Professor
 
 
 
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Contact

 

+44 (0)7554 342 293robert.istepanian Website

 
 
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Location

 

Central FacultyFaculty BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

143 results found

Mas JR, Navarro EAV, Ramos CH, Iglesias AA, Navajas JF, Bardají AV, Istepanian RSH, Moros JGet al., 2006, Design of an enhanced 3G-based mobile healthcare system, Handbook of Research on Mobile Multimedia, Pages: 521-533, ISBN: 9781591408666

An enhanced mobile healthcare multi-collaborative system operating over Third Generation (3G) mobile networks is presented. This chapter describes the design and use of this system in different medical and critical emergency scenarios provided with universal mobile telecommunications system (UMTS) accesses. In these environments, it is designed to communicate healthcare personnel with medical specialists in a remote hospital. The system architecture is based on advanced signalling protocols that allow multimedia multi-collaborative conferences in IPv4/IPv6 3G scenarios. The system offers real-time transmission of medical data and videoconference, together with other non real-time services. It has been optimized specifically to operate over 3G mobile networks using the most appropriate codecs. Evaluation results show a reliable performance over IPv4 UMTS accesses (64 Kbps in the uplink). In the future, advances in m-Health systems will make easier for mobile patients to interactively get the medical attention and advice they need. © 2006, Idea Group Inc.

BOOK CHAPTER

Zou Y, Istepanian RSH, Huang W, 2006, Performance evaluation of a GPRS/Bluetooth diabetes management system

Diabetes management has been playing an important role on preventing or delaying occurrence of the life threatening diabetes complications. By providing a roaming operation environment, mobile healthcare technologies can bring efficiencies and convenience to both diabetics and relative medics on diabetes management. This paper briefly introduces a system called MDMIS that operates across Bluetooth and live GPRS networks for pervasive diabetes management. As the major contribution of this work, a comprehensive study on system performance of MDMIS in real world networking environments is carried out. The main purpose of this study is to examine the quality of service of MDMIS for daily diabetes management. Experimental results show that the application of Bluetooth/GPRS in mobile disease management is feasible.

CONFERENCE PAPER

Garawi S, Istepanian RSH, Abu-Rgheff MA, 2006, 3G wireless communications for mobile robotic tele-ultrasonography systems, IEEE Communications Magazine, Vol: 44, Pages: 91-96, ISSN: 0163-6804

Mobile healthcare (m-health) is a new paradigm that brings together the evolution of emerging wireless communications and network technologies with the concept of 'connected healthcare' anytime and anywhere. In this article, we present the performance analysis of an end-to-end mObile Tele-Echography using an ultra-Light rObot (OTELO), over the third-generation (3G) mobile communications network. The experimental setup of the OTELO system over a 3G connectivity link used to measure the system performance is described. The performance of the relevant medical data and the relevant quality of service (QoS) issues defined in terms of the average throughput, delta-time packet delay, and jitter delay are investigated. The real-time 3G performance results show the successful operation of this bandwidth demanding robotic m-health system. © 2006 IEEE.

JOURNAL ARTICLE

Alesanco A, Olmos S, Istepanian RSH, García Jet al., 2006, Enhanced real-time ECG coder for packetized telecardiology applications., IEEE Trans Inf Technol Biomed, Vol: 10, Pages: 229-236, ISSN: 1089-7771

A new real-time compression method for electrocardiogram (ECG) signals has been developed based on the wavelet transform approach. The method is specifically adaptable for packetized telecardiology applications. The signal is segmented into beats and a beat template is subtracted from them, producing a residual signal. Beat templates and residual signals are coded with a wavelet expansion. Compression is achieved by selecting a subset of wavelet coefficients. The number of selected coefficients depends on a threshold which has different definitions depending on the operational mode of the coder. Compression performance has been tested using a subset of ECG records from MIT-BIH Arrhythmia database. This method has been designed for real-time packetized telecardiology scenarios both in wired and wireless environments.

JOURNAL ARTICLE

Prag NA, Yeghiazarian A, Istepanian RSH, 2006, Telemedicine business models focusing on emerging mobile technologies for chronic disease management: UK perspective, 1st Transdisciplinary Conference on Distributed Diagnosis and Home Healthcare (D2H2), Publisher: IEEE, Pages: 133-136

CONFERENCE PAPER

Alesanco A, García J, Serrano P, Ramos L, Istepanian RHet al., 2006, On the guarantee of reconstruction quality in ECG wavelet codecs., Conf Proc IEEE Eng Med Biol Soc, Vol: 1, Pages: 6461-6464, ISSN: 1557-170X

Guaranteeing reconstruction quality in ECG lossy compression is essential to obtain signals useful from a clinical point of view. In this paper we discuss the advantages and drawbacks of using two very well known mathematical error measures (PRD and RMS) in order to guarantee quality in threshold wavelet compression codecs that work segmenting the signal into blocks. We use two different error indices to analyze the results: mathematical (RMS global error) and clinical (MOS error). Although mathematical results conclude that guaranteeing RMS is better than PRD, clinical results have shown that the election is subordinated to the signal specific morphology.

JOURNAL ARTICLE

Tan Y-YE, Philip N, Istepanian RH, 2006, Fragility issues of medical video streaming over 802.11e-WLAN m-health environments., Conf Proc IEEE Eng Med Biol Soc, Vol: 1, Pages: 6316-6319, ISSN: 1557-170X

This paper presents some of the fragility issues of a medical video streaming over 802.11e-WLAN in m-health applications. In particular, we present a medical channel-adaptive fair allocation (MCAFA) scheme for enhanced QoS support for IEEE 802.11 (WLAN), as a modification for the standard 802.11e enhanced distributed coordination function (EDCF) is proposed for enhanced medical data performance. The medical channel-adaptive fair allocation (MCAFA) proposed extends the EDCF, by halving the contention window (CW) after zeta consecutive successful transmissions to reduce the collision probability when channel is busy. Simulation results show that MCAFA outperforms EDCF in-terms of overall performance relevant to the requirements of high throughput of medical data and video streaming traffic in 3G/WLAN wireless environments.

JOURNAL ARTICLE

Zou Y, Istepanian RSH, Bain SC, 2005, Policy driven mobile agents for ubiquitous medical diagnosis assistant system, Pages: 3-7

Ubiquity has been a key element to modern medical diagnosis system to improve medical service's efficiency and convenience on both medical personals and patients sides. Mobile agents and SIP technology make this anticipation possible. This paper proposes an approach to a ubiquitous medical diagnosis assistant system based on SIP, mobile agents and policy driven technology. First we describe mobile agent and SIP technology, and how they can integrate together at diagnosis assistant system. Second, we present a conceptual model for this medical diagnosis assistant system. Finally, a typical application scenario on diabetes management is described. © 2005 IEEE.

CONFERENCE PAPER

Istepanian RSH, 2005, Wireless security for personalised and mobile healthcare services, ISSN: 0730-3157

m-Health is a new and evolving research discipline that is defined as emerging merging mobile communications and network technologies for healthcare. This new evolutionary research area will involve the provision of new paradigms in healthcare that will provide both the health care professionals and patients with an efficient, secure, ubiquitous and robust infrastructure coupled with tools for the assessment and management of patient health status and the support of preventive and patient empowerment programmes [1,2]. However, for such new services to be provided, in which patient confidential data will be routinely transferred between mobile devices having no prior knowledge of each other, robust new security services will be essential. These will have to be based on new security paradigms that, unlike today, cannot assume the presence of common trusted third parties, or require the patients to use cumbersome key or password management techniques. The assessment and the trustworthiness of "stranger" devices such as future wireless wearbles and implantable devices will need to replace the former or some of the existing secuirty methodologies. Issues such as context awareness and mobile ubiqioutous computing systems will be the drivbing force fr such development in exisiting secuirty architectutes and technologies that will be compatible with the requriement of such systems and services and the whole m-health security infrastructure will need to be autonomic and predictive with self annealing so that it can determine when it is being attacked or not. For example, some of the major features in current 3G security systems such IMS architectures, Link and higher levels security systems together with new confidentiality and integrity algorithms and authentication plans need to be revised and investigated further to address the compatibility and functionality issues of these technologies and architectures with the demanding and robust security and confidentialit

CONFERENCE PAPER

Loizou CP, Pattichis CS, Christodoulou CI, Istepanian RSH, Pantziaris N, Nicolaides Aet al., 2005, Comparative evaluation of despeckle filtering in ultrasound imaging of the carotid artery, IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, Vol: 52, Pages: 1653-1669, ISSN: 0885-3010

JOURNAL ARTICLE

Wang XH, Istepanian RSH, Geake T, Hayes J, Desco M, Kontaxakis G, Santos A, Prentza A, Pavlopoulos Set al., 2005, A feasibility study of a personalized, internet-based compliance system for chronic disease management., Telemed J E Health, Vol: 11, Pages: 559-566, ISSN: 1530-5627

This paper describes a feasibility study on an Internet-based compliance system to provide personalized care for patients suffering from chronic diseases. Relevant medical trials from three different European countries provided preliminary evidence of the feasibility of the system and its efficacy in helping patients to manage their diseases at home. The study discusses further improvements not only for the C-Monitor system, but also for other Internet-based health-care services.

JOURNAL ARTICLE

Choi JM, Istepanian RSH, Alesanco A, Wang Het al., 2005, Hardware Design & Compression Issues in Compact Bluetooth Enabled Wireless Telecardiology System, 2nd International Conference on Broadband Networks (BroadNets 05), Publisher: IEEE, Pages: 91-92

CONFERENCE PAPER

Alesanco A, Istepanian R, Garcia J, 2005, The effects of transmission errors in ECG real-time wavelet compression codecs, 32nd Annual Conference on Computers in Cardiology, Publisher: IEEE, Pages: 45-48, ISSN: 0276-6574

CONFERENCE PAPER

Istepanian RSH, Philip N, 2005, Optimisation Issues of High Throughput Medical Data and Video Streaming Traffic in 3G Wireless Environments., Stud Health Technol Inform, Vol: 114, Pages: 125-131, ISSN: 0926-9630

In this paper we describe some of the optimisation issues relevant to the requirements of high throughput of medical data and video streaming traffic in 3G wireless environments. In particular we present a challenging 3G mobile health care application that requires a demanding 3G medical data throughput. We also describe the 3G QoS requirement of mObile Tele-Echography ultra-Light rObot system (OTELO that is designed to provide seamless 3G connectivity for real-time ultrasound medical video streams and diagnosis from a remote site (robotic and patient station) manipulated by an expert side (specialists) that is controlling the robotic scanning operation and presenting a real-time feedback diagnosis using 3G wireless communication links.

JOURNAL ARTICLE

Courreges F, Vieyres P, Istepanian RSH, Arbeille P, Bru Cet al., 2005, Clinical trials and evaluation of a mobile, robotic tele-ultrasound system., J Telemed Telecare, Vol: 11 Suppl 1, Pages: 46-49, ISSN: 1357-633X

We have developed a robotic tele-ultrasound system (OTELO) that allows an expert to examine a distant patient by ultrasound. At the expert station, a sonographer controls a virtual probe. Movements are reproduced at the patient station, which may be several kilometres away, on a real probe held by a lightweight robot, which is positioned on the patient by a paramedic. Two medical teams tested the tele-ultrasound system at two different hospitals on a total of 52 patients. Except for some difficulties caused by particular conditions, the diagnosis obtained with the remote scanning system agreed in at least 80% of the cases with the diagnosis made by conventional scanning. The results demonstrate the feasibility and efficiency of the device.

JOURNAL ARTICLE

Garawi SA, Courreges F, Istepanian RSH, Zisimopoulos H, Gosset Pet al., 2004, Performance analysis of a compact robotic tele-echography E-health system over terrestrial and mobile communication links, Pages: 118-122, ISSN: 0537-9989

In this work, we present a comparative performance analysis of an end-to-end Robotic tele-echography system using two means of communication links; Satellite and mobile (GPRS and UMTS) links. The functional modalities of the system in terms of the Delay, Total Throughput and the Jitter has been investigated, showing the capabilities and limitations of each communication link. The effect of concurrent and asynchronous system data transmission have been studied. The transmission of still and stream of ultrasound images investigated under different network conditions, simulated and on real network. The limitation of the GPRS network with respect to the other communication links options, has been verified and analysed. The outcome of the study is showing that the UMTS network, is a promising communication link for OTELO system.

CONFERENCE PAPER

Istepanian R, Jovanov E, Zhang YT, 2004, Introduction to the special section on M-Health: beyond seamless mobility and global wireless health-care connectivity., IEEE Trans Inf Technol Biomed, Vol: 8, Pages: 405-414, ISSN: 1089-7771

JOURNAL ARTICLE

Loizou CP, Pattichis CS, Istepanian RSH, Pantziaris M, Tyllis T, Nicolaides Aet al., 2004, Quality evaluation of ultrasound imaging in the carotid artery, Pages: 395-398

Image quality assessment plays an important role in various image-processing applications. In this work we evaluate image quality criteria based on mean square error, signal to noise error, and quality and structural similarity indices on ultrasound imaging of the carotid artery. These criteria as well as statistical and texture features were computed on 80 images recorded from two different ultrasound scanners before and after despeckle filtering, and after despeckle filtering and normalization. Results showed that image quality was improved after despeckle filtering and normalization for both scanners. This finding is also in agreement with the optical perception evaluation carried out by two vascular experts.

CONFERENCE PAPER

Raju NSG, Anthony JP, Jamadagni RS, Istepanian R, Suri Jet al., 2004, Status of mobile computing in health care: An evidence study, PROCEEDINGS OF THE 26TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7, Vol: 26, Pages: 3274-3277, ISSN: 1094-687X

JOURNAL ARTICLE

Istepanian R, Philip N, Wang XH, Laxminarayan Set al., 2004, Non-telephone healthcare: the role of 4G and emerging mobile systems for future m-health systems., Stud Health Technol Inform, Vol: 103, Pages: 465-470, ISSN: 0926-9630

The next generation of "m-health technologies" is a new and evolving topic in the areas of telemedical and telecare systems. These technologies involve the exploitation of mobile telecommunication and multimedia technologies to provide better access to healthcare personnel on the move, by removing the key disadvantage of trailing wires in current systems. These technologies provide equal access to medical information and expert care by overcoming the boundaries of separation that exist today between different users of such medical information. A great benefit to all users will be a more efficient use of resources and far greater location independence. In this paper we will address some notes and future trends in these emerging areas and their applications for m-health systems. Especially we will discuss the role of 4G and emerging mobile systems for future m-health systems. The new technologies can make the remote medical monitoring, consulting, and health care more flexible and convenient. But, there are challenges for successful wireless telemedicine, which are addressed in this paper.

JOURNAL ARTICLE

Loizou CP, Pattichis CS, Istepanian RSH, Pantziaris M, Nicolaides Aet al., 2004, Atherosclerotic carotid plaque segmentation., Conf Proc IEEE Eng Med Biol Soc, Vol: 2, Pages: 1403-1406, ISSN: 1557-170X

Atherosclerosis is the major cause of heart attack and stroke in the western world. In this paper we present a computerized method for segmenting the athrerosclerotic carotid plaque from ultrasound images. The method uses the blood flow image first to detect the initial contour of the plaque, and then despeckle filtering and snakes to deform the initial contour for best fit of plaque boundaries. The accuracy and reproducibility of this method was tested using 35 longitudinal ultrasound images of carotid arteries and the results were compared with the manual delineations of an expert. The comparison showed that the computerized method gives satisfactory results with no manual correction needed in most of the cases. The true positive fraction, TPF, true negative fraction, TNF, false negative fraction, FNF and false positive fraction, FPF, were 86.44%, 84.03%, 8.5%, and 7% respectively.

JOURNAL ARTICLE

Courreges F, Vieyres P, Istepanian RSH, 2004, Advances in robotic tele-echography services--the OTELO system., Conf Proc IEEE Eng Med Biol Soc, Vol: 7, Pages: 5371-5374, ISSN: 1557-170X

This paper presents some of the recent advances in mobile robotic tele-echography systems. It discussed the feasibility of a reliable remote ultrasound examination using such robotic systems in wireless environments. That is to say, to make use emerging wireless communications to provide a medical expert or consultant the ability to examine a remote patient. A critical issue of such systems is the accurate interactivity between both remote sides. The paper presents a robotic teleoperated OTELO (mobile tele-echography using an ultra-light robot) system for such purposes. The paper presents an overview of the system and some of preliminary tests and the use of wireless communication in this e-health application.

JOURNAL ARTICLE

Istepanian RSH, Lacal JC, 2003, Emerging Mobile Communication Technologies for Health: Some Imperative Notes on m-health, Pages: 1414-1416, ISSN: 0589-1019

The next generation of "wireless e-health technologies" is a new and evolving topic in the areas of telemedical and telecare systems. These technologies involve the exploitation of mobile telecommunication and multimedia technologies to provide better access to healthcare personnel on the move, by removing the key disadvantage of trailing wires in current systems. These technologies provide equal access to medical information and expert care by overcoming the boundaries of separation that exist today between different users of such medical information. A great benefit to all users will be a more efficient use of resources and far greater location independence. In this paper we will address some notes and future trends in these emerging areas and their applications for m-health systems. We will also discuss current as well as future strategies for implementing these system within important healthcare sectors as well as critical medical environments.

CONFERENCE PAPER

Wang XH, Istepanian RSH, 2003, A Web Based Service for Patients Compliance to Disease Treatment, Pages: 1417-1420, ISSN: 0589-1019

With the support from EU government, a new web based platform has been developed to monitor the patients compliance to disease treatment. The new platform can provide a wide range of services to both the physicians and the patients. It can allow the physician to define and create the medical scenario more flexible, to create the personalized therapeutic plan for the patients so that the patients can actively participate in the disease treatment. The platform is being medically tested in three European countries.

CONFERENCE PAPER

Wang XH, Istepanian RSH, Song YH, 2003, Microarray image enhancement by denoising using stationary wavelet transform., IEEE Trans Nanobioscience, Vol: 2, Pages: 184-189, ISSN: 1536-1241

Microarray imaging is considered an important tool for large scale analysis of gene expression. The accuracy of the gene expression depends on the experiment itself and further image processing. It's well known that the noises introduced during the experiment will greatly affect the accuracy of the gene expression. How to eliminate the effect of the noise constitutes a challenging problem in microarray analysis. Traditionally, statistical methods are used to estimate the noises while the microarray images are being processed. In this paper, we present a new approach to deal with the noise inherent in the microarray image processing procedure. That is, to denoise the image noises before further image processing using stationary wavelet transform (SWT). The time invariant characteristic of SWT is particularly useful in image denoising. The testing result on sample microarray images has shown an enhanced image quality. The results also show that it has a superior performance than conventional discrete wavelet transform and widely used adaptive Wiener filter in this procedure.

JOURNAL ARTICLE

Wang XH, Istepanian RSH, Song YH, 2003, Application of wavelet modulus maxima in microarray spots recognition., IEEE Trans Nanobioscience, Vol: 2, Pages: 190-192, ISSN: 1536-1241

This paper presents a novel approach to recognize the microarray image spots. The approach is based on the detection of wavelet modulus maxima in the microarray images. The detected maxima is actually the contour of the spots and thus the spots are recognized precisely. Then, the intensities within the contour of the spots can be obtained with low error rate. The test results on example image show this is an effective approach, especially for those spots with low intensities.

JOURNAL ARTICLE

Istepanian RSH, 2003, Microarray image processing: current status and future directions., IEEE Trans Nanobioscience, Vol: 2, Pages: 173-175, ISSN: 1536-1241

JOURNAL ARTICLE

Alesanco A, Olmos S, Istepanian R, Garcia Jet al., 2003, A novel real-time multilead ECG compression and de-noising method based on the wavelet transform, 30th Annual Meeting on Computers in Cardiology, Publisher: IEEE, Pages: 593-596, ISSN: 0276-6574

CONFERENCE PAPER

Istepanian RSH, Woodward B, 2003, The design and evaluation of a programmable underwater acoustic biotelemetry system for diver monitoring, Pages: 95-104, ISSN: 1436-7947

The design and evaluation of a novel programmable multi-channel digital underwater acoustic biotelemetry system using single-chip microcontrollers is described. It is intended for monitoring the respiration rate, heart rate (or the electrocardiogram, ECG) and depth of a free-swimming diver, and may be described as a through-water telemedicine system. Owing to its modular design, the system can be adapted for the transmission of digital data representing any physiological or physical parameter. The use of a microcontroller in the transmitter allows signals from each sensor to be transmitted in a priority-interrupt time-division multiplexed format with programmable frequency coding. An identical microcontroller in the receiver scans the frequency-coded signals, which are captured and interfaced to a computer for further processing.

CONFERENCE PAPER

Tachakra S, Wang XH, Istepanian RSH, Song YHet al., 2003, Mobile e-health: the unwired evolution of telemedicine., Telemed J E Health, Vol: 9, Pages: 247-257, ISSN: 1530-5627

The movement of telemedicine from desktop platforms to wireless and mobile configurations may have a significant impact on future health care. This paper reviews some of the latest technologies in wireless communication and their application in health care. The new technologies can make the remote medical monitoring, consulting, and health care more flexible and convenient. But, there are challenges for successful wireless telemedicine, which are addressed in this paper.

JOURNAL ARTICLE

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