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@article{Wang:2018:10.1021/acsami.8b15661,
author = {Wang, S and Ha, Y and Huang, X and Chin, B and Sim, W and Chen, R},
doi = {10.1021/acsami.8b15661},
journal = {ACS Applied Materials and Interfaces},
pages = {36622--36627},
title = {A new strategy for intestinal drug delivery via pH-responsive and membrane-active nanogels},
url = {http://dx.doi.org/10.1021/acsami.8b15661},
volume = {10},
year = {2018}
}

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TY  - JOUR
AB  - Oral administration of hydrophobic and poorly intestinal epithelium-permeable drugs is a significant challenge. Herein, we report a new strategy to overcome this problem by using novel, pH-responsive, and membrane-active nanogels as drug carriers. Prepared by simple physical cross-linking of amphiphilic pseudopeptidic polymers with pH-controlled membrane-activity, the size and hydrophobicity–hydrophilicity balance of the nanogels could be well-tuned. Furthermore, the amphiphilic nanogels could release hydrophobic payloads and destabilize cell membranes at duodenum and jejunum pH 5.0–6.0, which suggests their great potential for intestinal drug delivery.
AU  - Wang,S
AU  - Ha,Y
AU  - Huang,X
AU  - Chin,B
AU  - Sim,W
AU  - Chen,R
DO  - 10.1021/acsami.8b15661
EP  - 36627
PY  - 2018///
SN  - 1944-8244
SP  - 36622
TI  - A new strategy for intestinal drug delivery via pH-responsive and membrane-active nanogels
T2  - ACS Applied Materials and Interfaces
UR  - http://dx.doi.org/10.1021/acsami.8b15661
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449239600005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/64691
VL  - 10
ER  -

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