Imperial College London
Alternate

ProfessorRongjunChen

Faculty of Engineering, Department of Chemical Engineering

Professor of Biomaterials Engineering
 
 
 
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Contact

 

+44 (0)20 7594 2070rongjun.chen Website

 
 
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Location

 

408ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Huang:2021:10.1039/d0tb02442b,
author = {Huang, Y and Wang, Z and Zhang, G and Ren, J and Yu, L and Liu, X and Yang, Y and Ravindran, A and Wong, C and Chen, R},
doi = {10.1039/d0tb02442b},
journal = {Journal of Materials Chemistry B},
pages = {1888--1895},
title = {A pH/redox-dual responsive, nanoemulsion-embedded hydrogel for efficient oral delivery and controlled intestinal release of magnesium ions},
url = {http://dx.doi.org/10.1039/d0tb02442b},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It remains a major challenge to achieve efficient oral delivery and controlled intestinal release of ions using hydrogels. Herein, we report a novel, pH/redox-dual responsive, nanoemulsion-embedded composite hydrogel to address this issue. The hydrogel was first synthesized by crosslinking a biocompatible, pH-responsive pseudopeptide, poly(L-lysine isophthalamide) (PLP), and redox-sensitive L-cystine dimethyl ester dihydrochloride (CDE). A suitable amount of magnesium acetate was encapsulated into oil-in-water nanoemulsions, which were then embedded into the lysine-based hydrogel. The resulting composite hydrogel collapsed into a compact structure at acidic gastric pH, but became highly swollen or degraded in the neutral and reducing intestinal environment. The ion release profiles indicated that the nanoemulsion-embedded composite hydrogel could well retain and protect magnesium ions in the simulated gastric fluid (SGF) buffer at pH 1.2, but efficiently release them in the simulated intestinal fluid (SIF) buffer at pH 6.8 in the presence of 1,4-dithiothreitol (DTT) as a reducing agent. Moreover, this composite hydrogel system displayed good biocompatibility. These results suggested that the pH/redox-dual responsive, nanoemulsion-embedded composite hydrogel could be a promising candidate for efficient oral delivery and controlled intestinal release of magnesium and other ions.
AU  - Huang,Y
AU  - Wang,Z
AU  - Zhang,G
AU  - Ren,J
AU  - Yu,L
AU  - Liu,X
AU  - Yang,Y
AU  - Ravindran,A
AU  - Wong,C
AU  - Chen,R
DO  - 10.1039/d0tb02442b
EP  - 1895
PY  - 2021///
SN  - 2050-750X
SP  - 1888
TI  - A pH/redox-dual responsive, nanoemulsion-embedded hydrogel for efficient oral delivery and controlled intestinal release of magnesium ions
T2  - Journal of Materials Chemistry B
UR  - http://dx.doi.org/10.1039/d0tb02442b
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/TB/D0TB02442B#!divAbstract
UR  - http://hdl.handle.net/10044/1/86607
VL  - 9
ER  -
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