Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

644 results found

ANDERSON RM, MAY RM, 1989, COMPLEX DYNAMIC BEHAVIOR IN THE INTERACTION BETWEEN HIV AND THE IMMUNE-SYSTEM, NATO ADVANCED RESEARCH WORKSHOP ON THEORETICAL MODELS FOR CELL TO CELL SIGNALLING, Publisher: ACADEMIC PRESS INC, Pages: 335-349

Conference paper

ANDERSON RM, MAY RM, GUPTA S, 1989, NON-LINEAR PHENOMENA IN HOST-PARASITE INTERACTIONS, PARASITOLOGY, Vol: 99, Pages: S59-S79, ISSN: 0031-1820

Journal article

Anderson RM, May RM, Gupta S, 1989, Non-linear phenomena in host-parasite interactions., Parasitology, Vol: 99 Suppl, Pages: S59-S79, ISSN: 0031-1820

The paper examines non-linear dynamical phenomena in host-parasite interactions by reference to a series of different problems ranging from the impact on transmission of control measures based on vaccination and chemotherapy, to the effects of immunological responses targeted at different stages in a parasite's life-cycle. Throughout, simple mathematical models are employed to aid in interpretation. Analyses reveal that the influence of a defined control measure on the prevalence or intensity of infection, whether vaccination or drug treatment, is non-linearly related to the magnitude of control effort (as defined by the proportion of individuals vaccinated or treated with a drug). Consideration of the relative merits of gametocyte and sporozoite vaccines against malarial parasites suggests that very high leves of cohort immunization will be required to block transmission in endemic areas, with the former type of vaccine being more effective in reducing transmission for a defined level of coverage and the latter being better with respect to a reduction in morbidity. The inclusion of genetic elements in analyses of the transmission of helminth parasites reveals complex non-linear patterns of change in the abundance of different parasite genotypes under selection pressures imposed by either the host immunological defences or the application of chemotherapeutic agents. When resistance genes are present in parasite populations, the degree to which abundance can be suppressed by chemotherapy depends critically on the frequency and intensity of application, with intermediate values of the former being optimal. A more detailed consideration of the impact of immunological defences on parasite population growth within an individual host, by reference to the erythrocytic cycle of malaria, suggests that the effectiveness of a given immunological response is inversely related to the life-expectancy of the target stage in the parasite's developmental cycle.

Journal article

NOKES DJ, ANDERSON RM, 1988, MEASLES, MUMPS, AND RUBELLA VACCINE - WHAT COVERAGE TO BLOCK TRANSMISSION, LANCET, Vol: 2, Pages: 1374-1374, ISSN: 0140-6736

Journal article

MAY RM, ANDERSON RM, 1988, THE TRANSMISSION DYNAMICS OF HUMAN IMMUNODEFICIENCY VIRUS (HIV), PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, Vol: 321, Pages: 565-607, ISSN: 0962-8436

Journal article

NOKES DJ, ANDERSON RM, 1988, THE USE OF MATHEMATICAL-MODELS IN THE EPIDEMIOLOGICAL-STUDY OF INFECTIOUS-DISEASES AND IN THE DESIGN OF MASS IMMUNIZATION PROGRAMS, EPIDEMIOLOGY AND INFECTION, Vol: 101, Pages: 1-20, ISSN: 0950-2688

Journal article

ANDERSON RM, 1988, EPIDEMIOLOGICAL MODELS AND PREDICTIONS, TROPICAL AND GEOGRAPHICAL MEDICINE, Vol: 40, Pages: S30-S39, ISSN: 0041-3232

Journal article

ANDERSON RM, MAY RM, 1988, EPIDEMIOLOGICAL PARAMETERS OF HIV TRANSMISSION, NATURE, Vol: 333, Pages: 514-519, ISSN: 0028-0836

Journal article

MEDLEY GF, ANDERSON RM, COX DR, BILLARD Let al., 1988, ESTIMATING THE INCUBATION PERIOD FOR AIDS PATIENTS - REPLY, NATURE, Vol: 333, Pages: 505-505, ISSN: 0028-0836

Journal article

MCLEAN AR, ANDERSON RM, 1988, MEASLES IN DEVELOPING-COUNTRIES .2. THE PREDICTED IMPACT OF MASS VACCINATION, EPIDEMIOLOGY AND INFECTION, Vol: 100, Pages: 419-442, ISSN: 0950-2688

Journal article

HASWELLELKINS MR, ELKINS DB, MANJULA K, MICHAEL E, ANDERSON RMet al., 1988, AN INVESTIGATION OF HOOKWORM INFECTION AND REINFECTION FOLLOWING MASS ANTHELMINTIC TREATMENT IN THE SOUTH INDIAN FISHING COMMUNITY OF VAIRAVANKUPPAM, PARASITOLOGY, Vol: 96, Pages: 565-577, ISSN: 0031-1820

Journal article

Haswell-Elkins MR, Elkins DB, Manjula K, Michael E, Anderson RMet al., 1988, An investigation of hookworm infection and reinfection following mass anthelmintic treatment in the south Indian fishing community of Vairavankuppam., Parasitology, Vol: 96 ( Pt 3), Pages: 565-577, ISSN: 0031-1820

Hookworm infections, as assessed by counting worms expelled following anthelmintic treatment and by egg output, were found to be of low prevalence and intensity in a South Indian fishing community. The initial overall prevalence of infection in the community was 43%, and the average burden was estimated at 2.2 hookworms per person. The age profiles of prevalence and intensity differed between males and females, with the latter harbouring significantly higher levels of infection. Children of both sexes under 10 years of age rarely harboured hookworms. Treatment with pyrantel pamoate was estimated to be 91% effective in clearing hookworm infections. Egg counts made on stools collected during an 11-month period of reinfection indicated that female patients became reinfected soon after treatment, while little hookworm egg excretion was observed in males during the observation period following treatment. Females acquired a significantly higher number of worms during the reinfection period compared with males, although the average burden in females reached only 28% of the initial, pre-treatment level. The hookworm population consisted of predominantly Necator americanus, and less than 10% of Ancylostoma duodenale. The parasites were highly aggregated within the host population with 10% of the community harbouring over 65% of the total hookworms. Low values of the negative binomial aggregation parameter, k, (indicating extreme over-dispersion) were recorded in groups stratified by age and sex. Highly significant positive correlations were observed between the initial (pre-treatment) and reinfection worm burdens of female (but not of male) patients. It is suggested that occupational practices related to walking through areas contaminated with hookworm larvae play an important role in generating the observed patterns of infection within this community.

Journal article

MEDLEY GF, BILLARD L, COX DR, ANDERSON RMet al., 1988, THE DISTRIBUTION OF THE INCUBATION PERIOD FOR THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, Vol: 233, Pages: 367-377, ISSN: 0080-4649

Journal article

ANDERSON RM, MAY RM, MCLEAN AR, 1988, POSSIBLE DEMOGRAPHIC CONSEQUENCES OF AIDS IN DEVELOPING-COUNTRIES, NATURE, Vol: 332, Pages: 228-234, ISSN: 0028-0836

Journal article

ELKINS DB, HASWELLELKINS M, ANDERSON RM, 1988, THE IMPORTANCE OF HOST AGE AND SEX TO PATTERNS OF REINFECTION WITH ASCARIS-LUMBRICOIDES FOLLOWING MASS ANTHELMINTIC TREATMENT IN A SOUTH INDIAN FISHING COMMUNITY, PARASITOLOGY, Vol: 96, Pages: 171-184, ISSN: 0031-1820

Journal article

Elkins DB, Haswell-Elkins M, Anderson RM, 1988, The importance of host age and sex to patterns of reinfection with Ascaris lumbricoides following mass anthelmintic treatment in a South Indian fishing community., Parasitology, Vol: 96 ( Pt 1), Pages: 171-184, ISSN: 0031-1820

Analysis of egg and worm counts of Ascaris recorded at various intervals following a mass anthelmintic treatment programme in a South Indian fishing community is presented. Three indices of infection in the community are compared, namely the prevalence and intensity of egg output (at 2, 6 and 11 months following treatment) and the number of worms expelled following an 11 month period of reinfection. Detailed examination of these measurements revealed significant associations with patient sex and age. The age-prevalence profile of Ascaris infection changed little over time (except immediately following treatment) with the peak prevalence found in the 5-9 year age group. Although 85% of both males and females harboured Ascaris initially, the prevalence following 11 months reinfection was decreased, due to a significantly lower proportion of males being reinfected. By the 11th month of reinfection, the age-intensity profiles of egg output were similar to those observed at initial treatment in the older age groups (10 years and above) and in male children (less than 10 years). However, a dramatic increase in the egg output of female children, greatly exceeding the initial mean, was observed within a 6 month period of reinfection. The intensity of egg output did not accurately reflect the abundance of Ascaris recovered via drug-induced expulsion following an 11 month period of reinfection. Although the egg output attained preintervention levels, the average worm intensity reached only half the initial value. The trends in the sex- and age-intensity profiles were consistent at the two sampling dates and showed similar patterns to the egg output curves. The relevance of the results to helminth control and the monitoring of reinfection is discussed.

Journal article

MCLEAN AR, ANDERSON RM, 1988, MEASLES IN DEVELOPING-COUNTRIES .1. EPIDEMIOLOGICAL PARAMETERS AND PATTERNS, EPIDEMIOLOGY AND INFECTION, Vol: 100, Pages: 111-133, ISSN: 0950-2688

Journal article

MAY RM, ANDERSON RM, MCLEAN AR, 1988, POSSIBLE DEMOGRAPHIC CONSEQUENCES OF HIV AIDS EPIDEMICS .1. ASSUMING HIV INFECTION ALWAYS LEADS TO AIDS, MATHEMATICAL BIOSCIENCES, Vol: 90, Pages: 475-505, ISSN: 0025-5564

Journal article

TINGLEY GA, BUTTERWORTH AE, ANDERSON RM, KARIUKI HC, KOECH D, MUGAMBI M, OUMA JH, SIONGOK TKA, STURROCK RFet al., 1988, PREDISPOSITION OF HUMANS TO INFECTION WITH SCHISTOSOMA-MANSONI - EVIDENCE FROM THE REINFECTION OF INDIVIDUALS FOLLOWING CHEMOTHERAPY, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 82, Pages: 448-452, ISSN: 0035-9203

Journal article

ANDERSON RM, 1988, THE ROLE OF MATHEMATICAL-MODELS IN THE STUDY OF HIV TRANSMISSION AND THE EPIDEMIOLOGY OF AIDS, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, Vol: 1, Pages: 241-256, ISSN: 1077-9450

Journal article

BLYTHE SP, ANDERSON RM, 1988, HETEROGENEOUS SEXUAL-ACTIVITY MODELS OF HIV TRANSMISSION IN MALE-HOMOSEXUAL POPULATIONS, IMA JOURNAL OF MATHEMATICS APPLIED IN MEDICINE AND BIOLOGY, Vol: 5, Pages: 237-260, ISSN: 0265-0746

Journal article

ANDERSON RM, MEDLEY GF, 1988, EPIDEMIOLOGY OF HIV INFECTION AND AIDS - INCUBATION AND INFECTIOUS PERIODS, SURVIVAL AND VERTICAL TRANSMISSION, AIDS, Vol: 2, Pages: S57-S63, ISSN: 0269-9370

Journal article

ANDERSON RM, 1988, THE EPIDEMIOLOGY OF HIV INFECTION - VARIABLE INCUBATION PLUS INFECTIOUS PERIODS AND HETEROGENEITY IN SEXUAL-ACTIVITY, JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, Vol: 151, Pages: 66-93, ISSN: 0035-9238

Journal article

BLYTHE SP, ANDERSON RM, 1988, VARIABLE INFECTIOUSNESS IN HIV TRANSMISSION MODELS, IMA JOURNAL OF MATHEMATICS APPLIED IN MEDICINE AND BIOLOGY, Vol: 5, Pages: 181-200, ISSN: 0265-0746

Journal article

BLYTHE SP, ANDERSON RM, 1988, DISTRIBUTED INCUBATION AND INFECTIOUS PERIODS IN MODELS OF THE TRANSMISSION DYNAMICS OF THE HUMAN IMMUNODEFICIENCY VIRUS (HIV), IMA JOURNAL OF MATHEMATICS APPLIED IN MEDICINE AND BIOLOGY, Vol: 5, Pages: 1-19, ISSN: 0265-0746

Journal article

NOKES DJ, JENNINGS R, ANDERSON RM, 1987, LONGITUDINAL SEROLOGICAL STUDY OF RUBELLA IMMUNITY IN SOUTH YORKSHIRE, LANCET, Vol: 2, Pages: 1156-1157, ISSN: 0140-6736

Journal article

Anderson RM, Medley GF, 1987, Schistosome economics., Parasitol Today, Vol: 3, Pages: 350-351, ISSN: 0169-4758

Journal article

ANDERSON RM, MEDLEY GF, 1987, SCHISTOSOME ECONOMICS, PARASITOLOGY TODAY, Vol: 3, Pages: 350-351, ISSN: 0169-4758

Journal article

SMITH G, GRENFELL BT, ANDERSON RM, BEDDINGTON Jet al., 1987, POPULATION BIOLOGY OF OSTERTAGIA-OSTERTAGI AND ANTHELMINTIC STRATEGIES AGAINST OSTERTAGIASIS IN CALVES, PARASITOLOGY, Vol: 95, Pages: 407-420, ISSN: 0031-1820

Journal article

GRENFELL BT, SMITH G, ANDERSON RM, 1987, THE REGULATION OF OSTERTAGIA-OSTERTAGI POPULATIONS IN CALVES - THE EFFECT OF PAST AND CURRENT EXPERIENCE OF INFECTION ON PROPORTIONAL ESTABLISHMENT AND PARASITE SURVIVAL, PARASITOLOGY, Vol: 95, Pages: 363-372, ISSN: 0031-1820

Journal article

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