Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{NTD:2019:10.12688/gatesopenres.13052.2,
author = {NTD, Modelling Consortium Schistosomiasis Group},
doi = {10.12688/gatesopenres.13052.2},
journal = {Gates Open Research},
pages = {1--25},
title = {Insights from quantitative and mathematical modelling on the proposed WHO 2030 goal for schistosomiasis [version 2; peer review: 3 approved]},
url = {http://dx.doi.org/10.12688/gatesopenres.13052.2},
volume = {3},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Schistosomiasis remains one of the neglected tropical diseases (NTDs) impacting millions of people around the world. The World Health Organization (WHO) recently proposed a goal of elimination as a public health problem (EPHP) for schistosomiasis to be reached by 2030. Current WHO treatment guidelines for achieving EPHP focus on targeting school-aged children. The NTD Modelling Consortium has developed mathematical models to study schistosomiasis transmission dynamics and the impact of control measures. Our modelling insights on Schistosoma mansoni have shown that EPHP is likely to be attainable in low to moderate prevalence settings using the current guidelines. However, as prevalence rises within high prevalence settings, EPHP is less likely to be achieved unless both school-aged children and adults are treated (with coverage levels increasing with the adult burden of infection). We highlight the challenges that are faced by treatment programmes, such as non-adherence to treatment and resurgence, which can hinder progress towards achieving and maintaining EPHP. Additionally, even though EPHP may be reached, prevalence can still be high due to persisting infections. Therefore, without interruption of transmission, treatment will likely have to continue to maintain EPHP. Further modelling work is being carried out, including extending our results to S. haematobium . By providing these modelling insights, we aim to inform discussions on the goals and treatment guidelines for schistosomiasis.
AU  - NTD,Modelling Consortium Schistosomiasis Group
DO  - 10.12688/gatesopenres.13052.2
EP  - 25
PY  - 2019///
SN  - 2572-4754
SP  - 1
TI  - Insights from quantitative and mathematical modelling on the proposed WHO 2030 goal for schistosomiasis [version 2; peer review: 3 approved]
T2  - Gates Open Research
UR  - http://dx.doi.org/10.12688/gatesopenres.13052.2
UR  - https://gatesopenresearch.org/articles/3-1517/v2
UR  - http://hdl.handle.net/10044/1/83641
VL  - 3
ER  -
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