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@article{Wolters:2020:10.1212/WNL.0000000000010022,
author = {Wolters, FJ and Chibnik, LB and Waziry, R and Anderson, R and Berr, C and Beiser, A and Bis, JC and Blacker, D and Bos, D and Brayne, C and Dartigues, J-F and Darweesh, SKL and Davis-Plourde, KL and de, Wolf F and Debette, S and Dufouil, C and Fornage, M and Goudsmit, J and Grasset, L and Gudnason, V and Hadjichrysanthou, C and Helmer, C and Ikram, MA and Ikram, MK and Joas, E and Kern, S and Kuller, LH and Launer, L and Lopez, OL and Matthews, FE and McRae-McKee, K and Meirelles, O and Mosley, TH and Pase, MP and Psaty, BM and Satizabal, CL and Seshadri, S and Skoog, I and Stephan, BCM and Wetterberg, H and Wong, MM and Zettergren, A and Hofman, A},
doi = {10.1212/WNL.0000000000010022},
journal = {Neurology},
pages = {e519--e531},
title = {Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium},
url = {http://dx.doi.org/10.1212/WNL.0000000000010022},
volume = {95},
year = {2020}
}

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TY  - JOUR
AB  - OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.
AU  - Wolters,FJ
AU  - Chibnik,LB
AU  - Waziry,R
AU  - Anderson,R
AU  - Berr,C
AU  - Beiser,A
AU  - Bis,JC
AU  - Blacker,D
AU  - Bos,D
AU  - Brayne,C
AU  - Dartigues,J-F
AU  - Darweesh,SKL
AU  - Davis-Plourde,KL
AU  - de,Wolf F
AU  - Debette,S
AU  - Dufouil,C
AU  - Fornage,M
AU  - Goudsmit,J
AU  - Grasset,L
AU  - Gudnason,V
AU  - Hadjichrysanthou,C
AU  - Helmer,C
AU  - Ikram,MA
AU  - Ikram,MK
AU  - Joas,E
AU  - Kern,S
AU  - Kuller,LH
AU  - Launer,L
AU  - Lopez,OL
AU  - Matthews,FE
AU  - McRae-McKee,K
AU  - Meirelles,O
AU  - Mosley,TH
AU  - Pase,MP
AU  - Psaty,BM
AU  - Satizabal,CL
AU  - Seshadri,S
AU  - Skoog,I
AU  - Stephan,BCM
AU  - Wetterberg,H
AU  - Wong,MM
AU  - Zettergren,A
AU  - Hofman,A
DO  - 10.1212/WNL.0000000000010022
EP  - 531
PY  - 2020///
SN  - 0028-3878
SP  - 519
TI  - Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium
T2  - Neurology
UR  - http://dx.doi.org/10.1212/WNL.0000000000010022
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32611641
UR  - http://hdl.handle.net/10044/1/82976
VL  - 95
ER  -

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