Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Imtiaz:2019:10.12688/gatesopenres.13077.1,
author = {Imtiaz, R and Campbell, SJ and Vegvari, C and Giardina, F and Malizia, V and De, Vlas SJ and Anderson, RM and Coffeng, LE},
doi = {10.12688/gatesopenres.13077.1},
journal = {Gates Open Research},
title = {Insights from quantitative analysis and mathematical modelling on the proposed who 2030 goals for soil-transmitted helminths.},
url = {http://dx.doi.org/10.12688/gatesopenres.13077.1},
volume = {3},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Soil-transmitted helminths (STHs) are a group of parasitic worms that infect humans, causing a wide spectrum of disease, notably anaemia, growth retardation, and delayed cognitive development. The three main STHs are Ascaris lumbricoides, Trichuris trichiura and hookworm (Necator americanus and Ancylostoma duodenale). Approximately 1.5 billion people are infected with STHs worldwide. The World Health Organization goal for 2030 is morbidity control, defined as reaching <2% prevalence of medium-to-high intensity infections in preschool-age children and school-age children (SAC). Treatment guidelines for achieving this goal have been recommended. The Neglected Tropical Diseases Modelling Consortium has developed mathematical and statistical models to quantify, predict, and evaluate the impact of control measures on STHs. These models show that the morbidity target can be achieved following current guidelines in moderate prevalence settings (20-50% in SAC). In high prevalence settings, semi-annual preventive chemotherapy (PC) ideally including adults, or at least women of reproductive age, is required. For T. trichiura, dual therapy with albendazole and ivermectin is required. In general, stopping PC is not possible without infection resurgence, unless effective measures for improved access to water, hygiene, and sanitation have been implemented, or elimination of transmission has been achieved. Current diagnostic methods are based on egg counts in stool samples, but these are known to have poor sensitivity at low prevalence levels. A target threshold for novel, more sensitive diagnostics should be defined relative to currently preferred diagnostics (Kato-Katz). Our analyses identify the extent of systematic non-access to treatment and the individual patterns of compliance over multiple rounds of treatment as the biggest unknowns and the main impediment to reaching the target. Moreover, the link between morbidity and infection intensity has not been fully elucidated.
AU  - Imtiaz,R
AU  - Campbell,SJ
AU  - Vegvari,C
AU  - Giardina,F
AU  - Malizia,V
AU  - De,Vlas SJ
AU  - Anderson,RM
AU  - Coffeng,LE
DO  - 10.12688/gatesopenres.13077.1
PY  - 2019///
TI  - Insights from quantitative analysis and mathematical modelling on the proposed who 2030 goals for soil-transmitted helminths.
T2  - Gates Open Research
UR  - http://dx.doi.org/10.12688/gatesopenres.13077.1
VL  - 3
ER  -
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