Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wright:2018:10.1186/s13071-018-2656-4,
author = {Wright, JE and Werkman, M and Dunn, J and Anderson, R},
doi = {10.1186/s13071-018-2656-4},
journal = {Parasites & Vectors},
title = {Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review},
url = {http://dx.doi.org/10.1186/s13071-018-2656-4},
volume = {11},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis,lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected withhelminths. Whilst the WHO treatment guidelines for helminth infections are mostly aimed at controlling morbidity,there has been a recent shift with some countries moving towards goals of disease elimination through mass drugadministration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populationsmay no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals ordemographic groups who are persistently infected, often termed as being “predisposed” to infection, and targettreatment at them.Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbasedpapers investigating predisposition to helminth infections published up to October 31st, 2017. Thevarying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised.Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection areidentified and discussed.Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistentevidence of predisposition to infection with certain species of human helminth was identified. Children were regularlyfound to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults.Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering ofinfection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showedevidence of familial predisposition. Whilst strong evidence for predisposition
AU  - Wright,JE
AU  - Werkman,M
AU  - Dunn,J
AU  - Anderson,R
DO  - 10.1186/s13071-018-2656-4
PY  - 2018///
SN  - 1756-3305
TI  - Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review
T2  - Parasites & Vectors
UR  - http://dx.doi.org/10.1186/s13071-018-2656-4
UR  - http://hdl.handle.net/10044/1/56734
VL  - 11
ER  -
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