Imperial College London

DrRylieGreen

Faculty of EngineeringDepartment of Bioengineering

Reader in Polymer Bioelectronics
 
 
 
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Contact

 

+44 (0)20 7594 0943rylie.green

 
 
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Location

 

2.06Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Green:2009:10.1016/j.biomaterials.2009.03.043,
author = {Green, RA and Lovell, NH and Poole-Warren, LA},
doi = {10.1016/j.biomaterials.2009.03.043},
journal = {Biomaterials},
pages = {3637--3644},
title = {Cell attachment functionality of bioactive conducting polymers for neural interfaces},
url = {http://dx.doi.org/10.1016/j.biomaterials.2009.03.043},
volume = {30},
year = {2009}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Bioactive coatings for neural electrodes that are tailored for cell interactions have the potential to produce superior implants with improved charge transfer capabilities. In this study synthetically produced anionically modified laminin peptides DEDEDYFQRYLI and DCDPGYIGSR were used to dope poly(3,4-ethylenedioxythiophene) (PEDOT) electrodeposited on platinum (Pt) electrodes. Performance of peptide doped films was compared to conventional polymer PEDOT/paratoluene sulfonate (pTS) films using SEM, XPS, cyclic voltammetry, impedance spectroscopy, mechanical hardness and adherence. Bioactivity of incorporated peptides and their affect on cell growth was assessed using a PC12 neurite outgrowth assay. It was demonstrated that large peptide dopants produced softer PEDOT films with a minimal decrease in electrochemical stability, compared to the conventional dopant, pTS. Cell studies revealed that the YFQRYLI ligand retained neurite outgrowth bioactivity when DEDEDYFQRYLI was used as a dopant, but the effect was strongly dependant on initial cell attachment. Alternate peptide dopant, DCDPGYIGSR was found to impart superior cell attachment properties when compared to DEDEDYFQRYLI, but attachment on both peptide doped polymers could be enhanced by coating with whole native laminin. © 2009 Elsevier Ltd. All rights reserved.
AU - Green,RA
AU - Lovell,NH
AU - Poole-Warren,LA
DO - 10.1016/j.biomaterials.2009.03.043
EP - 3644
PY - 2009///
SN - 0142-9612
SP - 3637
TI - Cell attachment functionality of bioactive conducting polymers for neural interfaces
T2 - Biomaterials
UR - http://dx.doi.org/10.1016/j.biomaterials.2009.03.043
VL - 30
ER -