Imperial College London

DrRylieGreen

Faculty of EngineeringDepartment of Bioengineering

Reader in Polymer Bioelectronics
 
 
 
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Contact

 

+44 (0)20 7594 0943rylie.green

 
 
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Location

 

2.06Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gilmour:2013:10.1080/02772248.2013.844429,
author = {Gilmour, AD and Green, RA and Thomson, CE},
doi = {10.1080/02772248.2013.844429},
journal = {Toxicological and Environmental Chemistry},
pages = {1129--1144},
title = {A low-maintenance, primary cell culture model for the assessment of carbon nanotube toxicity},
url = {http://dx.doi.org/10.1080/02772248.2013.844429},
volume = {95},
year = {2013}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Carbon nanotubes (CNTs) have gained substantial interest as a material for biomedical devices with reliable properties suitable for electrically conducting biomedical devices. While CNTs combine ideal properties for a number of tissue-interfacing applications, their biocompatibility and safety have been the source of considerable conjecture. This study outlines a method for evaluating biocompatibility, using a low-cost, short-term assessment model of CNT with primary cells, which are more representative of an in vivo situation than cell lines. It was demonstrated that carboxylate-modified, multi-walled CNTs exhibit cytotoxic behavior in as little as 6 hr of exposure to primary fibroblasts. The resultant cell death was concentration dependent, demonstrating the efficacy of acute assessment of cytocompatibility. Although cell viability remained relatively high (being above 85% for all CNT concentrations up to 500 μg/ml), these results reflect similar relationships found for longer term exposures. This method has reliable potential for high-throughput assessment and quality control of CNTs in biomedical applications using a primary cell model. © 2013 © 2013 Taylor & Francis.
AU - Gilmour,AD
AU - Green,RA
AU - Thomson,CE
DO - 10.1080/02772248.2013.844429
EP - 1144
PY - 2013///
SN - 1029-0486
SP - 1129
TI - A low-maintenance, primary cell culture model for the assessment of carbon nanotube toxicity
T2 - Toxicological and Environmental Chemistry
UR - http://dx.doi.org/10.1080/02772248.2013.844429
VL - 95
ER -