Imperial College London

DrRylieGreen

Faculty of EngineeringDepartment of Bioengineering

Reader in Polymer Bioelectronics
 
 
 
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Contact

 

+44 (0)20 7594 0943rylie.green

 
 
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Location

 

2.06Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ouyang:2011:10.1016/B978-0-444-53815-4.00001-7,
author = {Ouyang, L and Green, R and Feldman, KE and Martin, DC},
doi = {10.1016/B978-0-444-53815-4.00001-7},
journal = {Progress in Brain Research},
pages = {263--271},
title = {Direct local polymerization of poly(3,4-ethylenedioxythiophene) in rat cortex},
url = {http://dx.doi.org/10.1016/B978-0-444-53815-4.00001-7},
volume = {194},
year = {2011}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Glial scar encapsulation is thought to be one of the major reasons for the failure of chronic brain-machine interfaces. Many strategies, including modification of the probe surface chemistry, delivery of anti-inflammatory drugs, and changes of probe geometry, have been employed to reduce glial scar formation. We have proposed that a possible means to establish long-term, reliable communication across the scar is the in situ polymerization of conjugated polymers such as PEDOT in neural tissue. Previously, we exposed entire brain slices to the EDOT monomer. Here, we demonstrate that PEDOT can be polymerized by the direct delivery of EDOT monomer to the reaction site. The monomer was delivered into rat cortex via microcannula and simultaneously electrochemically polymerized within the tissue using a microwire electrode. We found that the resulting PEDOT polymer cloud grew out from the working electrode tip and extended far out into the brain tissue, spanning distances more than 1. mm. We also examined the morphology of resulting polymer cloud by optical microscopy. © 2011 Elsevier B.V.
AU - Ouyang,L
AU - Green,R
AU - Feldman,KE
AU - Martin,DC
DO - 10.1016/B978-0-444-53815-4.00001-7
EP - 271
PY - 2011///
SN - 1875-7855
SP - 263
TI - Direct local polymerization of poly(3,4-ethylenedioxythiophene) in rat cortex
T2 - Progress in Brain Research
UR - http://dx.doi.org/10.1016/B978-0-444-53815-4.00001-7
VL - 194
ER -