Imperial College London
Alternate

ProfessorRylieGreen

Faculty of Engineering, Department of Bioengineering

Head of the Department of Bioengineering
 
 
 
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Contact

 

+44 (0)20 7594 0943rylie.green

 
 
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Location

 

3.05Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cuttaz:2019:10.1039/c8bm01235k,
author = {Cuttaz, E and Goding, J and Vallejo-Giraldo, C and Aregueta-Robles, U and Lovell, N and Ghezzi, D and Green, RA},
doi = {10.1039/c8bm01235k},
journal = {Biomaterials Science},
pages = {1372--1385},
title = {Conductive elastomer composites for fully polymeric, flexible bioelectronics},
url = {http://dx.doi.org/10.1039/c8bm01235k},
volume = {7},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Flexible polymeric bioelectronics have the potential to address the limitations of metallic electrode arrays by minimizing the mechanical mismatch at the device-tissue interface for neuroprosthetic applications. This work demonstrates the straightforward fabrication of fully organic electrode arrays based on conductive elastomers (CEs) as a soft, flexible and stretchable electroactive composite material. CEs were designed as hybrids of polyurethane elastomers (PU) and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), with the aim of combining the electrical properties of PEDOT:PSS with the mechanical compliance of elastomers. CE composites were fabricated by solvent casting of PEDOT:PSS dispersed in dissolved PU at different conductive polymer (CP) loadings, from 5 wt% to 25 wt%. The formation of PEDOT:PSS networks within the PU matrix and the resultant composite material properties were examined as a function of CP loading. Increased PEDOT:PSS loading was found to result in a more connected network within the PU matrix, resulting in increased conductivity and charge storage capacity. Increased CP loading was also determined to increase the Young's modulus and reduce the strain at failure. Biological assessment of CE composites showed them to mediate ReNcell VM human neural precursor cell adhesion. The increased stiffness of CE films was also found to promote neurite outgrowth. CE sheets were directly laser micromachined into a functional array and shown to deliver biphasic waveforms with comparable voltage transients to Pt arrays in in vitro testing.
AU  - Cuttaz,E
AU  - Goding,J
AU  - Vallejo-Giraldo,C
AU  - Aregueta-Robles,U
AU  - Lovell,N
AU  - Ghezzi,D
AU  - Green,RA
DO  - 10.1039/c8bm01235k
EP  - 1385
PY  - 2019///
SN  - 2047-4830
SP  - 1372
TI  - Conductive elastomer composites for fully polymeric, flexible bioelectronics
T2  - Biomaterials Science
UR  - http://dx.doi.org/10.1039/c8bm01235k
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30672514
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/BM/C8BM01235K
UR  - http://hdl.handle.net/10044/1/83768
VL  - 7
ER  -
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