Imperial College London
Alternate

ProfessorRylieGreen

Faculty of Engineering, Department of Bioengineering

Head of the Department of Bioengineering
 
 
 
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Contact

 

+44 (0)20 7594 0943rylie.green

 
 
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Location

 

3.05Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Syed:2020:10.1007/978-3-030-41854-0_8,
author = {Syed, O and Chapman, C and Vallejo-Giraldo, C and Genta, M and Goding, J and Kanelos, E and Green, R},
booktitle = {Neural Interface Engineering: Linking the Physical World and the Nervous System},
doi = {10.1007/978-3-030-41854-0_8},
pages = {201--236},
title = {3D Cell Culture Systems for the Development of Neural Interfaces},
url = {http://dx.doi.org/10.1007/978-3-030-41854-0_8},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Neural interface research and development covers a wide spectrum of topics, spanning basic neuroscience to design of implantable devices. In vitro studies have been an integral part of this research and form the basis of regulated preclinical studies. Historically, 2D cell cultures have provided substantial data on neural interfaces; however, these have inherent limitations. Critically, they do not recapitulate essential features of the in vivo environment, having limited cell-cell and cell-ECM interactions. This has driven the development of 3D cell culture models. Three approaches to 3D models are discussed, encompassing explant/ex vivo models, cell-only approaches, and biomaterials and scaffolds. Each approach offers advantages and limitations, which recommend them to specific applications. These issues are discussed with focus on their contributions to neural interface research.
AU  - Syed,O
AU  - Chapman,C
AU  - Vallejo-Giraldo,C
AU  - Genta,M
AU  - Goding,J
AU  - Kanelos,E
AU  - Green,R
DO  - 10.1007/978-3-030-41854-0_8
EP  - 236
PY  - 2020///
SN  - 9783030418533
SP  - 201
TI  - 3D Cell Culture Systems for the Development of Neural Interfaces
T1  - Neural Interface Engineering: Linking the Physical World and the Nervous System
UR  - http://dx.doi.org/10.1007/978-3-030-41854-0_8
ER  -
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