Imperial College London
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DrSaraAhmadi Abhari

Faculty of Medicine, School of Public Health

Lecturer in the Epidemiology of Ageing
 
 
 
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Contact

 

s.ahmadi-abhari Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lindbohm:2019:10.1016/S2468-2667(19)30023-4,
author = {Lindbohm, J and Sipila, PN and Mars, NJ and Pentti, J and Ahmadi-Abhari, S and Brunner, EJ and Shipley, MJ and Singh-Manoux, A and Tabak, AG and Kivimaki, M},
doi = {10.1016/S2468-2667(19)30023-4},
journal = {Lancet Public Health},
pages = {E189--E199},
title = {5-year versus risk-category-specific screening intervals for cardiovascular disease prevention: a cohort study},
url = {http://dx.doi.org/10.1016/S2468-2667(19)30023-4},
volume = {4},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Clinical guidelines suggest preventive interventions such as statin therapy for individuals with a highestimated 10-year risk of major cardiovascular events. For those with a low or intermediate estimated risk, risk-factorscreenings are recommended at 5-year intervals; this interval is based on expert opinion rather than on direct researchevidence. Using longitudinal data on the progression of cardiovascular disease risk over time, we compared differentscreening intervals in terms of timely detection of high-risk individuals, cardiovascular events prevented, and healthcare costs.Methods We used data from participants in the British Whitehall II study (aged 40–64 years at baseline) who hadrepeated biomedical screenings at 5-year intervals and linked these data to electronic health records between baseline(Aug 7, 1991, to May 10, 1993) and June 30, 2015. We estimated participants’ 10-year risk of a major cardiovascularevent (myocardial infarction, cardiac death, and fatal or non-fatal stroke) using the revised AtheroscleroticCardiovascular Disease (ASCVD) calculator. We used multistate Markov modelling to estimate optimum screeningintervals on the basis of progression rates from low-risk and intermediate-risk categories to the high-risk category(ie, ≥7·5% 10-year risk of a major cardiovascular event). Our assessment criteria included person-years spent in ahigh-risk category before detection, the number of major cardiovascular events prevented and quality-adjusted lifeyears (QALYs) gained, and screening costs.Findings Of 6964 participants (mean age 50·0 years [SD 6·0] at baseline) with 152700 person-years of follow-up (meanfollow-up 22·0 years [SD 5·0]), 1686 participants progressed to the high-risk category and 617 had a majorcardiovascular event. With the 5-year screening intervals, participants spent 7866 (95% CI 7130–8658) person-yearsunrecognised in the high-risk group. For individuals in the low
AU  - Lindbohm,J
AU  - Sipila,PN
AU  - Mars,NJ
AU  - Pentti,J
AU  - Ahmadi-Abhari,S
AU  - Brunner,EJ
AU  - Shipley,MJ
AU  - Singh-Manoux,A
AU  - Tabak,AG
AU  - Kivimaki,M
DO  - 10.1016/S2468-2667(19)30023-4
EP  - 199
PY  - 2019///
SN  - 2468-2667
SP  - 189
TI  - 5-year versus risk-category-specific screening intervals for cardiovascular disease prevention: a cohort study
T2  - Lancet Public Health
UR  - http://dx.doi.org/10.1016/S2468-2667(19)30023-4
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000463375200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/74921
VL  - 4
ER  -
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