Publications
217 results found
Suman-Horduna I, Babu-Narayan SV, Ernst S, 2013, Remote Navigation for Complex Arrhythmia., Arrhythm Electrophysiol Rev, Vol: 2, Pages: 53-58, ISSN: 2050-3369
Magnetic navigation has been established as an alternative to conventional, manual catheter navigation for invasive electrophysiology interventions about a decade ago. Besides the obvious advantage of radiation protection for the operator who is positioned remotely from the patient, there are additional benefits of steering the tip of a very floppy catheter. This manuscript reviews the published evidence from simple arrhythmias in patients with normal cardiac anatomy to the most complex congenital heart disease. This progress was made possible by the introduction of improved catheters and most importantly irrigated-tip electrodes.
Valente AM, Gauvreau K, Assenza GE, et al., 2013, Rationale and Design of an International Multicenter Registry of Patients With Repaired Tetralogy of Fallot to Define Risk Factors for Late Adverse Outcomes: The INDICATOR Cohort, PEDIATRIC CARDIOLOGY, Vol: 34, Pages: 95-104, ISSN: 0172-0643
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- Citations: 34
Ueda A, Horduna I, Mantziari L, et al., 2012, Contribution of Remote Magnetic Navigation to Supraventricular Tachycardia Ablation in Complex Congenital Heart Diseases, CIRCULATION, Vol: 126, ISSN: 0009-7322
Ueda A, Horduna I, Mantziari L, et al., 2012, Electrophysiological Characteristics in Different Types of Univentricular Physiology, CIRCULATION, Vol: 126, ISSN: 0009-7322
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- Citations: 1
Suman-Horduna I, Ueda A, Mantziari L, et al., 2012, Duplication of the Conduction System in Heterotaxy Syndrome Delineated Using Remote Magnetic Navigation and Three-Dimensional Mapping, CIRCULATION, Vol: 126, ISSN: 0009-7322
Bonello B, Kempny A, Uebing A, et al., 2012, New arrhythmias predictor factors in adults with repaired tetralogy of fallot, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 1028-1028, ISSN: 0195-668X
Torii R, El-Hamamsy I, Donya M, et al., 2012, Integrated morphologic and functional assessment of the aortic root after different tissue valve root replacement procedures, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 143, Pages: 1422-+, ISSN: 0022-5223
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- Citations: 30
Babu-Narayan SV, Keegan J, Ernst SIS, 2012, Emerging roles for cardiovascular magnetic resonance in adult congenital heart disease electrophysiology, Magnetic Resonance Imaging of Congenital Heart Disease, Pages: 303-320, ISBN: 9781447142669
The population of adults with congenital heart disease is growing. Most children with congenital heart disease now survive into adulthood thanks to innovations in cardiac surgery that allow repair or palliation of many anatomical defects. However, arrhythmia and sudden death remain important causes of late morbidity and mortality. As the population of adult congenital heart disease (ACHD) ages there is an increasing burden of arrhythmia requiring specialist care. Rhythm disturbances may be the first presenting symptom and herald a need for surgical or transcatheter reintervention in which case treatment should be directed at the underlying cardiovascular hemodynamics. In this case electrophysiological intervention is a secondary concern. Arrhythmia and sudden cardiac death may, alternatively occur in the absence of a target hemodynamic lesion. Arrhythmia mechanisms vary according to the exact underlying anatomic congenital defect and method and timing of surgical repair. Whilst the arrhythmia can relate to underlying structural heart disease, such as Wolff-Parkinson-White syndrome associated with Ebstein's anomaly, it often relates to surgically acquired scars combined with chamber enlargement as a consequence of abnormal pressure and volume loads. In congenital heart disease, atrial arrhythmias frequently emanate from the right atrium or right ventricle and are not generally confined to the left atrium as with atrial fibrillation triggered by pulmonary vein muscle bundles. ACHD patients with atrial arrhythmia are at particular risk of tachycardia induced cardiomyopathy and existing hemodynamic lesions such as valvular regurgitation may be exacerbated by arrhythmia. There is also overlap in clinical presentations, such that ACHD patients presenting with atrial arrhythmia are at higher risk of ventricular arrhythmia [1]. Atrial arrhythmia is well recognized as an important indicator of ventricular dysfunction in congenital heart disease [2]. Adults with congenital he
Bonello B, Kempny A, Uebing A, et al., 2012, RIGHT ATRIAL SIZE PREDICTS ARRHYTHMIA AND DEATH IN PATIENTS WITH REPAIRED TETRALOGY OF FALLOT, 61st Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: E798-E798, ISSN: 0735-1097
Babu-Narayan SV, Uebing A, Davlouros PA, et al., 2012, Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)., Int J Cardiol, Vol: 154, Pages: 299-305
Optimal treatment for stable repaired tetralogy of Fallot (rTOF) patients with pulmonary regurgitation (PR) and related right ventricular (RV) dilatation, including timing of valve implantation, remains uncertain. We sought to study tolerability of the angiotensin-converting-enzyme (ACE) inhibitor ramipril and its effects on cardiovascular function in these patients.
Ernst S, Babu-Narayan SV, Keegan J, et al., 2012, Remote-Controlled Magnetic Navigation and Ablation With 3D Image Integration as an Alternative Approach in Patients With Intra-Atrial Baffle Anatomy, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 5, Pages: 131-139, ISSN: 1941-3149
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- Citations: 46
Babu-Narayan SV, Gatzoulis MA, 2011, Tetralogy of Fallot, Pages: 316-327
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- Citations: 9
Teo LLS, Cannell T, Babu-Narayan SV, et al., 2011, Prevalence of Associated Cardiovascular Abnormalities in 500 Patients With Aortic Coarctation Referred for Cardiovascular Magnetic Resonance Imaging to a Tertiary Center, PEDIATRIC CARDIOLOGY, Vol: 32, Pages: 1120-1127, ISSN: 0172-0643
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- Citations: 54
Babu-Narayan SV, Mohiaddin RH, Cannell TM, et al., 2011, Cardiovascular changes after transcatheter endovascular stenting of adult aortic coarctation, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 149, Pages: 157-163, ISSN: 0167-5273
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- Citations: 13
Babu-Narayan SV, Gatzoulis MA, 2010, Tetralogy of Fallot, Diagnosis and Management of Adult Congenital Heart Disease: Second Edition, Pages: 316-327, ISBN: 9780702034268
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- Citations: 1
El-Hamamsy I, Torii R, Babu-Narayan S, et al., 2010, LATE AORTIC ROOT BIOMECHANICS FOLLOWING DIFFERENT AORTIC ROOT REPLACEMENT OPERATIONS, CANADIAN JOURNAL OF CARDIOLOGY, Vol: 26, Pages: 118D-118D, ISSN: 0828-282X
Beerbaum P, Valverde I, Greil GF, et al., 2010, Baffles and Conduits, Pages: 316-344
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- Citations: 2
Uebing A, Arvanitis P, Li W, et al., 2010, Effect of pregnancy on clinical status and ventricular function in women with heart disease, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 139, Pages: 50-59, ISSN: 0167-5273
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- Citations: 51
Johansson B, Babu-Narayan SV, Kilner PJ, et al., 2010, 3-dimensional time-resolved contrast-enhanced magnetic resonance angiography for evaluation late after the mustard operation for transposition., Cardiol Young, Vol: 20, Pages: 1-7
PURPOSE: Cardiovascular magnetic resonance assessment of adults late after an atrial redirection operation for transposition is demanding and time consuming. We hypothesised that the relatively fast and standardised 3-dimensional time-resolved contrast-enhanced magnetic resonance angiography, or dynamic angiography, would be valuable in the periodic follow-up of these patients. METHODS: We investigated prospectively 36 adults with transposition using dynamic angiography, comparing our results against a comprehensive but non-contrast cardiovascular magnetic resonance protocol. We acquired 6 dynamic angiographic datasets after injection of contrast. The primary aim was to detect significant obstruction of the pathways for venous flow. RESULTS: In 4 patients (11%), we found evidence of moderate-to-severe, and thus clinically important, obstruction of systemic venous channels on standard cardiovascular magnetic resonance. All these patients were correctly identified by dynamic angiography. In 4 additional patients, we found mild and haemodynamically insignificant obstructions in the systemic venous channels. Of the 8 (22%) patients with any obstruction, 6 were detected by angiography. There were no false positives reported, giving sensitivity of 75% and specificity of 100%, a positive predictive value of 100%, and negative predictive value of 93%. In 1 patient, there was a moderate obstruction of the pulmonary venous compartment which was not readily seen by dynamic angiography. CONCLUSIONS: 3-dimensional dynamic angiography is a useful method for detecting anatomically moderate-to-severe, but not mild, obstructions in the systemic venous channels following Mustard repair for transposition. This technique can be used as a single imaging method and/or as complimentary to standard two dimensional cardiovascular magnetic resonance techniques for detection of clinically important obstructions in the systemic venous channels.
Johansson B, Babu-Narayan SV, Kilner PJ, et al., 2010, 3-dimensional time-resolved contrast-enhanced magnetic resonance angiography for evaluation late after the Mustard operation for transposition, CARDIOLOGY IN THE YOUNG, Vol: 20, Pages: 1-7, ISSN: 1047-9511
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- Citations: 5
Babu-Narayan SV, 2010, The role of late gadolinium enhancement cardiovascular magnetic resonance in the assessment of congenital and acquired heart disease, Progress in Pediatric Cardiology, Vol: 28, Pages: 11-19, ISSN: 1058-9813
Cardiovascular magnetic resonance imaging (CMR) has become a cornerstone in the diagnosis and management of congenital heart disease and selected paediatric cardiology patients. This article reviews the relevance of late gadolinium enhancement (LGE) CMR in both congenital and acquired heart diseases. Commonly, adult LGE CMR is with a view to understanding myocardial viability in older ischaemic heart disease patients, where the extent, location, pattern and transmurality of LGE relate to longer term outcomes. However, LGE findings also contribute to diagnosing non-ischaemic cardiomyopathies and their potential aetiology. New uses also include using LGE CMR as an outcome measure in the assessment of interventions including pharmacotherapies. With time there is emerging data regarding a potential role for LGE CMR in risk stratification for arrhythmia and sudden cardiac death. There is therefore understandable interest in its relevance from clinicians involved in assessing and caring for cardiovascular disease in the young, whether congenital or acquired and early reports in these settings are discussed. After outlining aspects concerning principle, practice and pitfalls of the technique, the described clinical experience of late gadolinium enhancement will be discussed. Robust research will be required to fully understand where LGE CMR will fit in with routine clinical paediatric cardiology and adult congenital practice but it seems likely to have a unique role to improve diagnosis and management strategies, determine response to therapies, and assess long term prognosis, not only in ischaemic heart disease patients, but in these cardiac patients too. © 2009 Elsevier Ireland Ltd. All rights reserved.
Perera R, Yadav R, Babu-Narayan S, et al., 2010, Pitfalls of Pectus Repair in Marfan Syndrome: a Case of Successful Re-operation on an Infected Ascending Aortic Graft in a Marfan Patient 20 Years After an Aortic Valve Sparing Root Replacement and Multiple Pectus Repair Operations, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Kilner PJ, Balossino R, Dubini G, et al., 2009, Pulmonary regurgitation: The effects of varying pulmonary artery compliance, and of increased resistance proximal or distal to the compliance, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 133, Pages: 157-166, ISSN: 0167-5273
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- Citations: 49
Griffin HR, Hall DH, Topf A, et al., 2009, Genetic Variation in <i>VEGF</i> Does Not Contribute Significantly to the Risk of Congenital Cardiovascular Malformation, PLOS ONE, Vol: 4, ISSN: 1932-6203
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- Citations: 20
Johansson B, Babu-Narayan SV, Kilner PJ, 2009, The effects of breath-holding on pulmonary regurgitation measured by cardiovascular magnetic resonance velocity mapping., J Cardiovasc Magn Reson.
Voges I, Fischer G, Scheewe J, et al., 2008, Restrictive enlargement of the pulmonary annulus at surgical repair of tetralogy of Fallot: 10-year experience with a uniform surgical strategy, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 34, Pages: 1041-1045, ISSN: 1010-7940
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- Citations: 23
Dimopoulos K, Diller G-P, Koltsida E, et al., 2008, Prevalence, predictors, and prognostic value of renal dysfunction in adults with congenital heart disease, CIRCULATION, Vol: 117, Pages: 2320-2328, ISSN: 0009-7322
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- Citations: 267
Uebing A, Babu-Narayan SV, Diller GP, et al., 2008, Response to letter regarding article, "Right Ventricular Mechanics and QRS Duration in Patients With Repaired Tetralogy of Fallot: Implications of Infundibular Disease", CIRCULATION, Vol: 117, Pages: E301-E301, ISSN: 0009-7322
Fellowes C, Daly C, Babu-Narayan SV, et al., 2008, Portentous pinball, CANADIAN JOURNAL OF CARDIOLOGY, Vol: 24, Pages: E3-E5, ISSN: 0828-282X
Babu-Narayan SV, Uebing A, Kilner PJ, et al., 2007, ACE inhibition improves systolic LV function in patients with pulmonary regurgitation and restrictive RV physiology late after repair of tetralogy of Fallot - A subgroup analysis of the APPROPRIATE study (ACE inhibitors for potential PRevention of the deleterious effects of pulmonary regurgitation in adults with TEtralogy of Fallot repair), 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 700-700, ISSN: 0009-7322
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