Imperial College London

Professor Sir Steve Bloom FMedSci, FRS

Faculty of MedicineDepartment of Medicine

Departmental Academic REF2014 Lead
 
 
 
//

Contact

 

+44 (0)20 3313 3242s.bloom Website

 
 
//

Assistant

 

Ms Keda Price-Cousins +44 (0)20 3313 3242

 
//

Location

 

Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

2990 results found

Abbara A, Clarke S, Islam R, Prague JK, Comninos A, Narayanaswamy S, Papadopoulou DA, Roberts RE, Izzi-Engbeaya CN, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery SA, Bloom SR, Huson L, Trew GH, Dhillo WSet al., 2018, Reply: Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking, HUMAN REPRODUCTION, Vol: 33, Pages: 342-344, ISSN: 0268-1161

JOURNAL ARTICLE

Anand U, Yiangou Y, Akbar A, Quick T, MacQuillan A, Fox M, Sinisi M, Korchev YE, Jones B, Bloom SR, Anand Pet al., 2018, Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Correa IR, Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas Aet al., 2018, A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic beta-Cells, DIABETES, Vol: 67, Pages: 385-399, ISSN: 0012-1797

JOURNAL ARTICLE

Cork SC, Eftekhar A, Mirza KB, Zuliani C, Nikolic K, Gardiner JV, Bloom SR, Toumazou Cet al., 2018, Extracellular pH monitoring for use in closed-loop vagus nerve stimulation, JOURNAL OF NEURAL ENGINEERING, Vol: 15, ISSN: 1741-2560

JOURNAL ARTICLE

Jones B, Bloom SR, Buenaventura T, Tomas A, Rutter GAet al., 2018, Control of insulin secretion by GLP-1, PEPTIDES, Vol: 100, Pages: 75-84, ISSN: 0196-9781

JOURNAL ARTICLE

Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Correa IR, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SRet al., 2018, Targeting GLP-1 receptor trafficking to improve agonist efficacy, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Khan R, Kanda N, Bloom SR, Rutter GA, Lindsley CW, Nance KD, Niswender KD, Jones B, Tomas Aet al., 2018, An investigation into the role of compound 5d in incretin-dependent pancreatic beta cell function, Publisher: WILEY, Pages: 54-54, ISSN: 0742-3071

CONFERENCE PAPER

Laughlin WE, Buenaventura T, Oqua AI, Kanda N, Walker A, Klymchenko AS, Bloom SR, Rutter GA, Hanyaloglu A, Jones B, Tomas Aet al., 2018, Control of glucagon-like peptide-1 receptor (GLP-1R) palmitoylation, lipid raft partitioning, clustering and signalling by biased agonism, Publisher: WILEY, Pages: 54-55, ISSN: 0742-3071

CONFERENCE PAPER

Law J, Morris DE, Izzi-Engbeaya C, Salem V, Coello C, Robinson L, Jayasinghe M, Scott R, Gunn R, Rabiner E, Tan T, Dhillo WS, Bloom S, Budge H, Symonds MEet al., 2018, Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans, JOURNAL OF NUCLEAR MEDICINE, Vol: 59, Pages: 516-522, ISSN: 0161-5505

JOURNAL ARTICLE

Magnuson EA, Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Braunwald E, Sabatine MS, Cohen DJet al., 2018, REPLY: Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction Analysis by Subgroups, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 71, Pages: 108-108, ISSN: 0735-1097

JOURNAL ARTICLE

Mirza KB, Alenda A, Eftekhar A, Grossman N, Nikolic K, Bloom SR, Toumazou Cet al., 2018, Influence of Cholecystokinin-8 on Compound Nerve Action Potentials from Ventral Gastric Vagus in Rats., Int J Neural Syst, ISSN: 0129-0657

OBJECTIVE: Vagus Nerve Stimulation (VNS) has shown great promise as a potential therapy for a number of conditions, such as epilepsy, depression and for Neurometabolic Therapies, especially for treating obesity. The objective of this study was to characterize the left ventral subdiaphragmatic gastric trunk of vagus nerve (SubDiaGVN) and to analyze the influence of intravenous injection of gut hormone cholecystokinin octapeptide (CCK-8) on compound nerve action potential (CNAP) observed on the same branch, with the aim of understanding the impact of hormones on VNS and incorporating the methods and results into closed loop implant design. METHODS: The cervical region of the left vagus nerve (CerVN) of male Wistar rats was stimulated with electric current and the elicited CNAPs were recorded on the SubDiaGVN under four different conditions: Control (no injection), Saline, CCK[Formula: see text] (100[Formula: see text]pmol/kg) and CCK[Formula: see text] (1000[Formula: see text]pmol/kg) injections. RESULTS: We identified the presence of A[Formula: see text], B, C1, C2, C3 and C4 fibers with their respective velocity ranges. Intravenous administration of CCK in vivo results in selective, statistically significant reduction of CNAP components originating from A and B fibers, but with no discernible effect on the C fibers in [Formula: see text] animals. The affected CNAP components exhibit statistically significant ([Formula: see text] and [Formula: see text]) higher normalized stimulation thresholds. CONCLUSION: This approach of characterizing the vagus nerve can be used in closed loop systems to determine when to initiate VNS and also to tune the stimulation dose, which is patient-specific and changes over time.

JOURNAL ARTICLE

Scott R, Minnion J, Tan T, Bloom SRet al., 2018, Oxyntomodulin analogue increases energy expenditure via the glucagon receptor, PEPTIDES, Vol: 104, Pages: 70-77, ISSN: 0196-9781

JOURNAL ARTICLE

Scott RV, Bloom SR, 2018, Problem or solution: The strange story of glucagon, PEPTIDES, Vol: 100, Pages: 36-41, ISSN: 0196-9781

JOURNAL ARTICLE

Abbara A, Clarke S, Islam R, Prague J, Comninos A, Narayanaswamy S, Papadopoulou D, Roberts R, Izzi-Engbeaya C, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery S, Bloom S, Huson L, Trew G, Dhillo Wet al., 2017, A second dose of kisspeptin safely optimizes oocyte maturation in women undergoing in IVF treatment: a phase 2 randomized controlled trial, 33rd Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 53-53, ISSN: 0268-1161

CONFERENCE PAPER

Abbara A, Clarke S, Islam R, Prague JK, Comninos AN, Narayanaswamy S, Papadopoulou D, Roberts R, Izzi-Engbeaya C, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery SA, Bloom SR, Huson L, Trew GH, Dhillo WSet al., 2017, A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial, HUMAN REPRODUCTION, Vol: 32, Pages: 1915-1924, ISSN: 0268-1161

JOURNAL ARTICLE

Alamshah A, Spreckley E, Norton M, Kinsey-Jones JS, Amin A, Ramgulam A, Cao Y, Johnson R, Saleh K, Akalestou E, Malik Z, Gonzalez-Abuin N, Jomard A, Amarsi R, Moolla A, Sargent PR, Gray GW, Bloom SR, Murphy KGet al., 2017, L-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents, INTERNATIONAL JOURNAL OF OBESITY, Vol: 41, Pages: 1693-1701, ISSN: 0307-0565

JOURNAL ARTICLE

Brooks L, Viardot A, Tsakmaki A, Stolarczyk E, Howard JK, Cani PD, Everard A, Sleeth ML, Psichas A, Anastasovskaj J, Bell JD, Bell-Anderson K, Mackay CR, Ghatei MA, Bloom SR, Frost G, Bewick GAet al., 2017, Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety, MOLECULAR METABOLISM, Vol: 6, Pages: 48-60, ISSN: 2212-8778

JOURNAL ARTICLE

Buenaventura T, Kanda N, Jones B, Correa IR, Bloom SR, Rutter GA, Tomas Aet al., 2017, Characterisation of glucagon-like peptide-1 (GLP-1) receptor trafficking and its significance for pancreatic beta cell function, DIABETIC MEDICINE, Vol: 34, Pages: 53-53, ISSN: 0742-3071

JOURNAL ARTICLE

Cegla J, Jones BJ, Gardiner JV, Hodson DJ, Marjot T, McGlone ER, Tan TM, Bloom SRet al., 2017, RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling, ENDOCRINOLOGY, Vol: 158, Pages: 2680-2693, ISSN: 0013-7227

JOURNAL ARTICLE

Cegla J, Jones BJ, Howard J, Kay R, Creaser CS, Bloom SR, Tan TMet al., 2017, The preanalytical stability of glucagon as measured by liquid chromatography tandem mass spectrometry and two commercially available immunoassays, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 54, Pages: 293-296, ISSN: 0004-5632

JOURNAL ARTICLE

Christakis I, Scott R, Minnion J, Cuenco J, Tan T, Palazzo F, Bloom Set al., 2017, Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model, JOURNAL OF INVESTIGATIVE SURGERY, Vol: 30, Pages: 162-169, ISSN: 0894-1939

JOURNAL ARTICLE

Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, Rabiner EA, Honigsperger C, Silva MR, Brandtzaeg OK, Lundanes E, Wilson SR, Brown RC, Thomas SA, Bloom SR, Dhillo WSet al., 2017, Kisspeptin modulates sexual and emotional brain processing in humans, JOURNAL OF CLINICAL INVESTIGATION, Vol: 127, Pages: 709-719, ISSN: 0021-9738

JOURNAL ARTICLE

Cuenco J, Minnion J, Tan T, Scott R, Germain N, Ling Y, Chen R, Ghatei M, Bloom Set al., 2017, Degradation Paradigm of the Gut Hormone, Pancreatic Polypeptide, by Hepatic and Renal Peptidases, ENDOCRINOLOGY, Vol: 158, Pages: 1755-1765, ISSN: 0013-7227

JOURNAL ARTICLE

Deharo P, Ducrocq G, Bode C, Cohen M, Cuisset T, Mehta SR, Pollack C, Wiviott SD, Elbez Y, Sabatine MS, Steg PGet al., 2017, Timing of Angiography and Outcomes in High-Risk Patients With Non-ST-Segment-Elevation Myocardial Infarction Managed Invasively Insights From the TAO Trial (Treatment of Acute Coronary Syndrome With Otamixaban), CIRCULATION, Vol: 136, Pages: 1895-+, ISSN: 0009-7322

JOURNAL ARTICLE

Glaysher MA, Mohanaruban A, Prechtl CG, Goldstone AP, Miras AD, Lord J, Chhina N, Falaschetti E, Johnson NA, Al-Najim W, Smith C, Li JV, Patel M, Ahmed AR, Moore M, Poulter N, Bloom S, Darzi A, Le Roux C, Byrne JP, Teare JPet al., 2017, A randomised controlled trial of a duodenal-jejunal bypass sleeve device (EndoBarrier) compared with standard medical therapy for the management of obese subjects with type 2 diabetes mellitus, BMJ OPEN, Vol: 7, ISSN: 2044-6055

JOURNAL ARTICLE

Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JVet al., 2017, Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight, CELL REPORTS, Vol: 19, Pages: 2202-2209, ISSN: 2211-1247

JOURNAL ARTICLE

Howard JW, Kay RG, Jones B, Cegla J, Tan T, Bloom S, Creaser CSet al., 2017, Development of a UHPLC-MS/MS (SRM) method for the quantitation of endogenous glucagon and dosed GLP-1 from human plasma, BIOANALYSIS, Vol: 9, Pages: 733-751, ISSN: 1757-6180

JOURNAL ARTICLE

Jones BJ, Scopelliti R, Tomas A, Bloom SR, Hodson DJ, Broichhagen Jet al., 2017, Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor, CHEMISTRYOPEN, Vol: 6, Pages: 501-505, ISSN: 2191-1363

JOURNAL ARTICLE

Keetarut K, Zacharopoulou-Otapasidou S, Bloom S, Majumdar A, Patel PSet al., 2017, An evaluation of the feasibility and validity of a patient-administered malnutrition universal screening tool ('MUST') compared to healthcare professional screening in an inflammatory bowel disease (IBD) outpatient clinic., J Hum Nutr Diet

BACKGROUND: Malnutrition is common in inflammatory bowel disease (IBD) and is associated with poor health outcomes. Despite this, screening for malnutrition in the outpatient-setting is not routine and research in the area is limited. The present study aimed to evaluate whether agreement between malnutrition screening completed by patients and healthcare professionals (HCPs) could be achieved by comparing patient self-administered 'MUST' ('MUST'-P) with HCP administered 'MUST' ('MUST'-HCP) in a single tertiary IBD outpatient clinic. METHODS: We conducted a feasibility and validity study on adult outpatients with IBD. We collected anthropometric, nutritional and clinical data from patients. All patients completed 'MUST'-P using a self-administered questionnaire, followed by 'MUST'-HCP. 'MUST'-P was timed and feedback on ease-of-use was obtained. The risk of malnutrition was classified as low (score = 0), medium (score = 1) and high (score ≥ 2) and agreement was tested using kappa statistics (κ). RESULTS: Eighty patients were recruited (Crohn's disease: n = 49, ulcerative colitis: n = 29, unclassified: n = 2), with a mean (SD) age of 39.9 (15.1) years (51.2% were males). Seventy-one (92%) of patients found 'MUST'-P either easy or very easy. The mean (SD) time to complete 'MUST'-P was 3.1  (1.8) min (range 1-10 min). Sixty-eight (85%) of patients were at low risk of malnutrition when screened by the HCP. There was moderate agreement (κ = 0.486, P < 0.001) between 'MUST'-P and 'MUST'-HCP, with 100% agreement in scoring for medium- and high-risk categories. CONCLUSIONS: The results of the present study suggests that self-screening using 'MUST' could be effectively used in an IBD outpatient clinic to identify those at medium and high risk of malnutrition. The patient friendly version of 'MUST' ('MUST'-P) was considered quick and easy to use by patient

JOURNAL ARTICLE

Prague JK, Roberts RE, Comninos AN, Clarke S, Jayasena CN, Nash Z, Doyle C, Papadopoulou D, Bloom SR, Mohideen P, Lin V, Stern T, Panay N, Hunter MS, Veldhuis JD, Webber LC, Huson L, Dhillo WSet al., 2017, Neurokinin 3 receptor antagonism is a highly effective, novel treatment for menopausal hot flushes with rapid onset: a phase 2, randomised, double-blind, placebo-controlled trial, 28th Annual Meeting of the North-American-Menopause-Society, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1429-1430, ISSN: 1072-3714

CONFERENCE PAPER

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00162552&limit=30&person=true