Publications
2554 results found
Borsay BA, Skrapits K, Herczeg L, et al., 2014, Hypophysiotropic Gonadotropin-Releasing Hormone Projections Are Exposed to Dense Plexuses of Kisspeptin, Neurokinin B and Substance P Immunoreactive Fibers in the Human: A Study on Tissues from Postmenopausal Women, NEUROENDOCRINOLOGY, Vol: 100, Pages: 141-152, ISSN: 0028-3835
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- Citations: 30
Price SL, Bloom SR, 2014, Protein PYY and Its Role in Metabolism, HOW GUT AND BRAIN CONTROL METABOLISM, Vol: 42, Pages: 147-154, ISSN: 0301-3073
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- Citations: 24
Chambers ES, Viardot A, Psichas A, et al., 2014, Targeted delivery of propionate to the colon stimulates the release of anorectic gut hormones and suppresses appetite in humans, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 73, Pages: E15-E15, ISSN: 0029-6651
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- Citations: 1
Raynaud J-P, Hodes M, Gau SS-F, 2014, Editorial introduction, From Research to Practice in Child and Adolescent Mental Health, Editors: Raynaud, Hodes, Gau, Publisher: Rowman & Littlefield Pub Incorporated, Pages: xiii-xv, ISBN: 9781442233072
This book has been shaped to reflect the mental health needs of children and adolescents in Low and Middle Income Countries (LAMIC).
Tan T, Bloom S, 2013, Gut hormones as therapeutic agents in treatment of diabetes and obesity, CURRENT OPINION IN PHARMACOLOGY, Vol: 13, Pages: 996-1001, ISSN: 1471-4892
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- Citations: 40
Boughton CK, Patel SA, Thompson EL, et al., 2013, Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats, REGULATORY PEPTIDES, Vol: 187, Pages: 6-11, ISSN: 0167-0115
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- Citations: 11
Jayasena CN, Comninos AN, Nijher GMK, et al., 2013, Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: 4464-4474, ISSN: 0021-972X
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- Citations: 22
Parker JA, McCullough KA, Field BCT, et al., 2013, Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala, INTERNATIONAL JOURNAL OF OBESITY, Vol: 37, Pages: 1391-1398, ISSN: 0307-0565
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- Citations: 58
Jayasena CN, Comninos AN, Veldhuis JD, et al., 2013, A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women, CLINICAL ENDOCRINOLOGY, Vol: 79, Pages: 558-563, ISSN: 0300-0664
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- Citations: 37
de Jonge C, Rensen SS, Verdam FJ, et al., 2013, Endoscopic Duodenal-Jejunal Bypass Liner Rapidly Improves Type 2 Diabetes, OBESITY SURGERY, Vol: 23, Pages: 1354-1360, ISSN: 0960-8923
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- Citations: 113
Jethwa PH, Small CJ, Patterson M, et al., 2013, Neuromedin U, Handbook of Biologically Active Peptides, Pages: 856-862, ISBN: 9780123850959
Tan TM, Bloom SR, 2013, Pancreatic Polypeptide, Handbook of Biologically Active Peptides, Pages: 1294-1299, ISBN: 9780123850959
Troke R, Tan TM, Bloom SR, 2013, PYY, Handbook of Biologically Active Peptides, Pages: 1160-1165, ISBN: 9780123850959
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- Citations: 2
Hrabovszky E, Borsay BA, Racz K, et al., 2013, Substance P Immunoreactivity Exhibits Frequent Colocalization with Kisspeptin and Neurokinin B in the Human Infundibular Region, PLoS ONE, Vol: 8, ISSN: 1932-6203
Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion. In search of neuropeptides co-expressed in analogous neurons of the human infundibular nucleus (Inf), we have carried out immunohistochemical studies of the tachykinin peptide Substance P (SP) in autopsy samples from men (21-78 years) and postmenopausal (53-83 years) women. Significantly higher numbers of SP-immunoreactive (IR) neurons and darker labeling were observed in the Inf of postmenopausal women than in age-matched men. Triple-immunofluorescent studies localized SP immunoreactivity to considerable subsets of KP-IR and NKB-IR axons and perikarya in the infundibular region. In postmenopausal women, 25.1% of NKB-IR and 30.6% of KP-IR perikarya contained SP and 16.5% of all immunolabeled cell bodies were triple-labeled. Triple-, double- and single-labeled SP-IR axons innervated densely the portal capillaries of the infundibular stalk. In quadruple-labeled sections, these axons formed occasional contacts with GnRH-IR axons. Presence of SP in NKB and KP neurons increases the functional complexity of the putative pulse generator network. First, it is possible that SP modulates the effects of KP and NKB in axo-somatic and axo-dendritic afferents to GnRH neurons. Intrinsic SP may also affect the activity and/or neuropeptide release of NKB and KP neurons via autocrine/paracrine actions. In the infundibular stalk, SP may influence the KP and NKB secretory output via additional autocrine/paracrine mechanisms or regulate GnRH neurosecretion directly. Finally, possible co-release of SP with KP and NKB into the portal circulation could underlie further actions on adenohypophysial gonadotrophs.
Sam A, Busbridge M, Amin A, et al., 2013, Hepcidin levels in diabetes mellitus and polycystic ovary syndrome, Diabetic Medicine, Vol: 30, Pages: 1495-1499, ISSN: 0742-3071
Venetikou MS, Meleagros L, Ghatei MA, et al., 2013, Pituitary protein 7B2 plasma levels in patients with liver disease: Comparisons with other hormones and neuropeptides, Oncology Letters, Vol: 6, Pages: 499-506, ISSN: 1792-1074
7B2, a protein initially isolated from the porcine pituitary gland, has been identified in numerous animal and human tissues, with the highest concentrations in the pituitary and hypothalamus. The 7B2 molecule is highly evolutionarily conserved and is considered to be indispensable in the function and regulation of proprotein convertase 2 (PC2). In the present study, the plasma 7B2 immunoreactivity (7B2-IR) of 18 patients with liver disease was studied. Of these patients, seven (three male and four female), aged 37–67 [54.6±13.5 (SD)] years, suffered from liver cirrhosis of cryptogenic (n=2) or alcoholic (n=5) aetiology. The remaining 11 patients (four male and seven female), aged 22–76 [56.1±17.6 (SD)] years, suffered from miscellaneous liver abnormalities. The clinical diagnosis was confirmed in the majority of patients by the histological examination of a percutaneous liver biopsy or by appropriate radiological investigations. Plasma bilirubin, alkaline phosphatase, aspartate aminotransferase, albumin, prothrombin time, electrolytes, urea and creatinine were measured. The plasma 7B2-IR levels were estimated using a sensitive radioimmunoassay (RIA), and the elution position of 7B2-IR was verified by gel chromatography. The mean plasma 7B2-IR concentration in patients with liver disease was 99.44±15.9 pmol/l. In the patients with hepatocellular damage due to metastatic tumours [Ca bronchus, carcinoid (n=6)], the 7B2-IR concentrations were significantly higher [185±36.9 pmol/l, (P<0.05)] compared with the overall subjects with liver damage. The results of the present study demonstrate that 7B2-IR is increased in liver disease, with the highest levels detected in patients with tumourous liver conditions.
Comninos AN, Jayasena CN, Nijher GMK, et al., 2013, Chronic kisspeptin administration advances the menstrual cycle in healthy women, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 334-335, ISSN: 0268-1161
Jayasena CN, Abbara A, Comninos AN, et al., 2013, Kisspeptin-54 administration stimulates pulsatile luteinising hormone secretion in women with hypothalamic amenorrhea, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 110-110, ISSN: 0268-1161
Bloom SR, 2013, Obesity, gut hormones and knighthood, Expert Review of Endocrinology and Metabolism, Vol: 8, Pages: 225-227, ISSN: 1744-6651
Hussain SS, Bloom SR, 2013, The regulation of food intake by the gut-brain axis: implications for obesity, INTERNATIONAL JOURNAL OF OBESITY, Vol: 37, Pages: 625-633, ISSN: 0307-0565
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- Citations: 130
Tan TM, Field BCT, McCullough KA, et al., 2013, Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia, DIABETES, Vol: 62, Pages: 1131-1138, ISSN: 0012-1797
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- Citations: 162
Kenkre J, Tan T, Bloom S, 2013, Treating the obese diabetic, EXPERT REVIEW OF CLINICAL PHARMACOLOGY, Vol: 6, Pages: 171-183, ISSN: 1751-2433
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- Citations: 7
Beale KEL, Gardiner JV, Bewick GA, et al., 2013, Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 168, Pages: 403-410, ISSN: 0007-1188
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- Citations: 26
Germain N, Minnion JS, Tan T, et al., 2013, Analogs of pancreatic polypeptide and peptide YY with a locked PP-fold structure are biologically active, PEPTIDES, Vol: 39, Pages: 6-10, ISSN: 0196-9781
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- Citations: 13
Scott R, Tan T, Bloom S, 2013, Gut Hormones and Obesity: Physiology and Therapies, OBESITY, Vol: 91, Pages: 143-194, ISSN: 0083-6729
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- Citations: 14
Bloom S, Ghatei M, Bech P, 2013, Measurement of gut hormones in plasma., Methods Mol Biol, Vol: 1065, Pages: 147-170
The gastrointestinal tract is the largest endocrine organ and was the site where the first hormones were discovered: secretin in 1902 and gastrin in 1905. Discovery of these gut peptides led to the concept of blood-borne communication between cells. Gut peptide hormones and neurotransmitters regulate the complex processes of digestion, motility, epithelial growth, and integrity. Investigation of this complex endocrine organ has depended on the development of well-characterized radioimmunoassays. Radioimmunoassays have increased our understanding of appetite regulation and of pathological processes affecting the gut, including gastroenteropancreatic neuroendocrine tumors. The object of this chapter is to provide an overview of measuring gastrointestinal hormones and neuropeptides by radioimmunoassay.
Hussain SS, de Silva A, Bloom SR, 2012, Control of food intake and appetite, Modern Nutrition in Health and Disease: Eleventh Edition, Pages: 589-600, ISBN: 9781605474618
Molnar CS, Vida B, Sipos MT, et al., 2012, Morphological Evidence for Enhanced Kisspeptin and Neurokinin B Signaling in the Infundibular Nucleus of the Aging Man, ENDOCRINOLOGY, Vol: 153, Pages: 5428-5439, ISSN: 0013-7227
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- Citations: 31
Hill NE, Murphy KG, Brett S, et al., 2012, CAN THE GASTRIC HORMONE GHRELIN ATTENUATE CATABOLISM AND ENHANCE RECOVERY AND REHABILITATION IN A RODENT MODEL OF ZYMOSAN PERITONITIS?, INTENSIVE CARE MEDICINE, Vol: 38, Pages: S122-S122, ISSN: 0342-4642
Hrabovszky E, Sipos MT, Molnar CS, et al., 2012, Low Degree of Overlap Between Kisspeptin, Neurokinin B, and Dynorphin Immunoreactivities in the Infundibular Nucleus of Young Male Human Subjects Challenges the KNDy Neuron Concept, ENDOCRINOLOGY, Vol: 153, Pages: 4978-4989, ISSN: 0013-7227
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- Citations: 76
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