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@article{Polyviou:2016:10.1111/apt.13749,
author = {Polyviou, T and MacDougall, K and Chambers, ES and Viardot, A and Psichas, A and Jawaid, S and Harris, HC and Edwards, CA and Simpson, L and Murphy, KG and Zac-Varghese, SE and Blundell, JE and Dhillo, WS and Bloom, SR and Frost, GS and Preston, T and Tedford, MC and Morrison, DJ},
doi = {10.1111/apt.13749},
journal = {Alimentary Pharmacology and Therapeutics},
pages = {662--672},
title = {Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon.},
url = {http://dx.doi.org/10.1111/apt.13749},
volume = {44},
year = {2016}
}

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TY  - JOUR
AB  - BACKGROUND: Short-chain fatty acids (SCFA) produced through fermentation of nondigestible carbohydrates by the gut microbiota are associated with positive metabolic effects. However, well-controlled trials are limited in humans. AIMS: To develop a methodology to deliver SCFA directly to the colon, and to optimise colonic propionate delivery in humans, to determine its role in appetite regulation and food intake. METHODS: Inulin SCFA esters were developed and tested as site-specific delivery vehicles for SCFA to the proximal colon. Inulin propionate esters containing 0-61 wt% (IPE-0-IPE-61) propionate were assessed in vitro using batch faecal fermentations. In a randomised, controlled, crossover study, with inulin as control, ad libitum food intake (kcal) was compared after 7 days on IPE-27 or IPE-54 (10 g/day all treatments). Propionate release was determined using (13) C-labelled IPE variants. RESULTS: In vitro, IPE-27-IPE-54 wt% propionate resulted in a sevenfold increase in propionate production compared with inulin (P < 0.05). In vivo, IPE-27 led to greater (13) C recovery in breath CO2 than IPE-54 (64.9 vs. 24.9%, P = 0.001). IPE-27 also led to a reduction in energy intake during the ad libitum test meal compared with both inulin (439.5 vs. 703.9 kcal, P = 0.025) and IPE-54 (439.5 vs. 659.3 kcal, P = 0.025), whereas IPE-54 was not significantly different from inulin control. CONCLUSIONS: IPE-27 significantly reduced food intake suggesting colonic propionate plays a role in appetite regulation. Inulin short-chain fatty acid esters provide a novel tool for probing the diet-gut microbiome-host metabolism axis in humans.
AU  - Polyviou,T
AU  - MacDougall,K
AU  - Chambers,ES
AU  - Viardot,A
AU  - Psichas,A
AU  - Jawaid,S
AU  - Harris,HC
AU  - Edwards,CA
AU  - Simpson,L
AU  - Murphy,KG
AU  - Zac-Varghese,SE
AU  - Blundell,JE
AU  - Dhillo,WS
AU  - Bloom,SR
AU  - Frost,GS
AU  - Preston,T
AU  - Tedford,MC
AU  - Morrison,DJ
DO  - 10.1111/apt.13749
EP  - 672
PY  - 2016///
SN  - 0269-2813
SP  - 662
TI  - Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon.
T2  - Alimentary Pharmacology and Therapeutics
UR  - http://dx.doi.org/10.1111/apt.13749
UR  - http://hdl.handle.net/10044/1/39439
VL  - 44
ER  -

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