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@article{Tan:2017:10.1210/jc.2017-00469,
author = {Tan, T and Behary, P and Tharakan, G and Minnion, J and Al-Najim, W and Albrechtsen, NJW and Holst, JJ and Bloom, SR},
doi = {10.1210/jc.2017-00469},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {2364--2372},
title = {The effect of a subcutaneous infusion of GLP-1, OXM, and PYY on energy intake and expenditure in obese volunteers},
url = {http://dx.doi.org/10.1210/jc.2017-00469},
volume = {102},
year = {2017}
}

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TY  - JOUR
AB  - Background:Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective treatment of obesity, although limited by availability and operative risk. The gut hormones Glucagon-like peptide-1 (GLP-1), Peptide YY (PYY), and Oxyntomodulin (OXM) are elevated postprandially after RYGB, which has been postulated to contribute to its metabolic benefits.Objective:We hypothesized that infusion of the three gut hormones to achieve levels similar to those encountered postprandially in RYGB patients might be effective in suppressing appetite. The aim of this study was to investigate the effect of a continuous infusion of GLP-1, OXM, and PYY (GOP) on energy intake and expenditure in obese volunteers.Methods:Obese volunteers were randomized to receive an infusion of GOP or placebo in a single-blinded, randomized, placebo-controlled crossover study for 10.5 hours a day. This was delivered subcutaneously using a pump device, allowing volunteers to remain ambulatory. Ad libitum food intake studies were performed during the infusion, and energy expenditure was measured using a ventilated hood calorimeter.Results:Postprandial levels of GLP-1, OXM, and PYY seen post RYGB were successfully matched using 4 pmol/kg/min, 4 pmol/kg/min, and 0.4 pmol/kg/min, respectively. This dose led to a mean reduction of 32% in food intake. No significant effects on resting energy expenditure were observed.Conclusion:This is, to our knowledge, the first time that an acute continuous subcutaneous
AU  - Tan,T
AU  - Behary,P
AU  - Tharakan,G
AU  - Minnion,J
AU  - Al-Najim,W
AU  - Albrechtsen,NJW
AU  - Holst,JJ
AU  - Bloom,SR
DO  - 10.1210/jc.2017-00469
EP  - 2372
PY  - 2017///
SN  - 0021-972X
SP  - 2364
TI  - The effect of a subcutaneous infusion of GLP-1, OXM, and PYY on energy intake and expenditure in obese volunteers
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/jc.2017-00469
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405621600029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/jcem/article/102/7/2364/3100443
UR  - http://hdl.handle.net/10044/1/82896
VL  - 102
ER  -

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Professor Sir Steve Bloom FMedSci, FRS

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