Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Professor of Systems Neuroscience



+44 (0)20 7594 7699s.brickley




402ASir Ernst Chain BuildingSouth Kensington Campus






BibTex format

author = {Jager, P and Ye, Z and Yu, X and Zagoraiou, L and Prekop, H-T and Partanen, J and Jessell, TM and Wisden, W and Brickley, SG and Delogu, A},
doi = {10.1038/ncomms13579},
journal = {Nature Communications},
title = {Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus},
url = {},
volume = {7},
year = {2016}

RIS format (EndNote, RefMan)

AB - The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABAA receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability.
AU - Jager,P
AU - Ye,Z
AU - Yu,X
AU - Zagoraiou,L
AU - Prekop,H-T
AU - Partanen,J
AU - Jessell,TM
AU - Wisden,W
AU - Brickley,SG
AU - Delogu,A
DO - 10.1038/ncomms13579
PY - 2016///
SN - 2041-1723
TI - Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
T2 - Nature Communications
UR -
UR -
UR -
VL - 7
ER -