Imperial College London

DrSubarnaChakravorty

Faculty of MedicineFaculty of Medicine Centre

Honorary Senior Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 3312 7682s.chakravorty

 
 
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Location

 

The Bays, South Wharf RdSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

17 results found

Fordham NJ, Ajitsaria R, Karnik L, Chakravorty Set al., 2016, Haemophagocytic Lymphohistiocytosis responding to withdrawal of gluten: a case report, Journal of Medical Case Reports, Vol: 10, ISSN: 1752-1947

IntroductionThis is the first documented case of a patient with Haemophagocytic Lymphohistiocytosis (HLH) in association with coeliac disease. There was complete clinical and biochemical remission of HLH following the introduction of a gluten free diet.Case presentationA seven-year old Caucasian girl presented with fevers, maculopapular rash with a recent history of tonsillitis. Blood tests revealed thrombocytopenia (64 x 109/L), anaemia (80g/L), hypofibrinogenaemia (1g/L) and hyperferritinaemia (71378µg/L). A bone marrow revealed evidence of haemophagocytosis, but tests for the genetic or familial associated HLH syndromes were negative. Screening tests for known secondary causes was negative. She was diagnosed with HLH, and following treatment with the HLH-2004 protocol these symptoms, in addition to the biochemical and haematological markers completely resolved. The patient presented again ten months later with fever, rash, and biochemical abnormalities suggestive of HLH. Tissue transglutamase was markedly raised and blood tests revealed a genetic susceptibly to coeliac disease in the form of HLA DQ2 positivity. She commenced a gluten free diet and there was complete symptomatic and biochemical response without any further chemotherapy. She had further episodic rashes, each associated with the accidental intake of gluten. ConclusionThis is to our knowledge the first documented case of HLH in association with coeliac disease. There was no other secondary cause found; she initially responded to chemo-immunotherapy specific for HLH but relapsed within a few months of cessation of treatment and then achieved complete remission on gluten withdrawal alone.

JOURNAL ARTICLE

Chakravorty S, Tallett A, Hay H, Chisholm A, Warner J, Sathyamoorthy G, James Jet al., 2015, Assessing the care experiences of people living with sickle cell disease to inform the development of a patient reported experience measure (PREM), 55th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL, Pages: 25-26, ISSN: 0007-1048

CONFERENCE PAPER

Chakravorty S, Williams TN, 2015, Sickle cell disease: a neglected chronic disease of increasing global health importance, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 100, Pages: 48-53, ISSN: 0003-9888

JOURNAL ARTICLE

Portsmore S, Chakravorty S, Oppong E, Ahmad R, Bain BJet al., 2015, Systemic EBV-positive lymphoproliferative disease of childhood, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 355-355, ISSN: 0361-8609

JOURNAL ARTICLE

de la Fuente J, Chakravorty S, Ayres R, Mkandawire Cet al., 2014, A Survey of the Management of Acute Chest Syndrome in Children with Sickle Cell Disease in Centres in UK and Western Europe, 56th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Baki Y, Chakravorty S, Bridges N, Karnik L, Roberts I, de la Fuente J, Moyo Y, Alexander Set al., 2013, Endocrine late effects post-haematopoietic stem cell transplant (HSCT) in children with haemoglobinopathies, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S373-S374, ISSN: 0268-3369

CONFERENCE PAPER

Jessen B, Bode SFN, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl WA, Gochuico BR, Griese M, Griffiths G, Janka G, Klein C, Koegl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford AD, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu GT, Zieger B, zur Stadt U, Aichele P, Ehl Set al., 2013, The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2, BLOOD, Vol: 121, Pages: 2943-2951, ISSN: 0006-4971

JOURNAL ARTICLE

Jones ML, Murden SL, Brooks C, Maloney V, Manning RA, Gilmour KC, Bharadwaj V, de la Fuente J, Chakravorty S, Mumford ADet al., 2013, Disruption of AP3B1 by a chromosome 5 inversion: a new disease mechanism in Hermansky-Pudlak syndrome type 2, BMC MEDICAL GENETICS, Vol: 14, ISSN: 1471-2350

JOURNAL ARTICLE

Bharadwaj V, Chakravorty S, Bain BJ, 2012, The cause of sudden anemia revealed by the blood film, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 520-520, ISSN: 0361-8609

JOURNAL ARTICLE

Chakravorty S, King MJ, Bain BJ, 2012, An unexpectedly bizarre blood film in hemoglobin H disease, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 1104-1104, ISSN: 0361-8609

JOURNAL ARTICLE

Chakravorty S, Roberts I, 2012, How I manage neonatal thrombocytopenia, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 156, Pages: 155-162, ISSN: 0007-1048

JOURNAL ARTICLE

Collier E, de la Fuente J, Chakravorty S, 2012, Prevalence and Effect of Coagulation Defects in Children Undergoing Bone Marrow Transplantation for Haemoglobinopathies., 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Ong M, Daly P, Chakravorty S, Roberts IAG, de la Fuente Jet al., 2012, Automated exchange transfusions for sickle cell disease are safe and feasible using peripheral access in the paediatric population, 52nd Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL, Pages: 72-72, ISSN: 0007-1048

CONFERENCE PAPER

Bhatnagar N, Erskine R, O'Boyle F, Chakravorty S, Roberts I, de la Fuente Jet al., 2011, Bone Marrow Transplantation Arrests Cerebrovascular Disease Progression and Improves Psychometric Outcomes in Children with Sickle Cell Disease, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 10-10, ISSN: 0006-4971

CONFERENCE PAPER

Bain BJ, Murray JA, Patterson KG, Chakravorty S, Ancliff P, Wong CC, Hann I, Wong C, Philpott N, Bolam S, Thomas Wet al., 2005, Slide session, British Society for Haematology, 45th Annual Scientific Meeting, Manchester, 2005, CLINICAL AND LABORATORY HAEMATOLOGY, Vol: 27, Pages: 363-369, ISSN: 0141-9854

JOURNAL ARTICLE

Chakravorty S, Murray N, Roberts I, 2005, Neonatal thrombocytopenia, EARLY HUMAN DEVELOPMENT, Vol: 81, Pages: 35-41, ISSN: 0378-3782

JOURNAL ARTICLE

Chakravorty S, Johnston R, Coulter C, Bain BJet al., 2004, Teaching cases from the Royal Marsden and St Mary's Hospitals, case 26: Refractory microcytic anaemia, LEUKEMIA & LYMPHOMA, Vol: 45, Pages: 1491-1492, ISSN: 1042-8194

JOURNAL ARTICLE

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