Imperial College London

DrSubarnaChakravorty

Faculty of MedicineFaculty of Medicine Centre

Honorary Senior Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 3312 7682s.chakravorty

 
 
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Location

 

The Bays, South Wharf RdSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

32 results found

Stotesbury H, Kirkham FJ, K├Âlbel M, Balfour P, Clayden JD, Sahota S, Sakaria S, Saunders DE, Howard J, Kesse-Adu R, Inusa B, Pelidis M, Chakravorty S, Rees DC, Awogbade M, Wilkey O, Layton M, Clark CA, Kawadler JMet al., 2018, White matter integrity and processing speed in sickle cell anemia., Neurology, Vol: 90, Pages: e2042-e2050

OBJECTIVE: The purpose of this retrospective cross-sectional study was to investigate whether changes in white matter integrity are related to slower processing speed in sickle cell anemia. METHODS: Thirty-seven patients with silent cerebral infarction, 46 patients with normal MRI, and 32 sibling controls (age range 8-37 years) underwent cognitive assessment using the Wechsler scales and 3-tesla MRI. Tract-based spatial statistics analyses of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) parameters were performed. RESULTS: Processing speed index (PSI) was lower in patients than controls by 9.34 points (95% confidence interval: 4.635-14.855, p = 0.0003). Full Scale IQ was lower by 4.14 scaled points (95% confidence interval: -1.066 to 9.551, p = 0.1), but this difference was abolished when PSI was included as a covariate (p = 0.18). There were no differences in cognition between patients with and without silent cerebral infarction, and both groups had lower PSI than controls (both p < 0.001). In patients, arterial oxygen content, socioeconomic status, age, and male sex were identified as predictors of PSI, and correlations were found between PSI and DTI scalars (fractional anisotropy r = 0.614, p < 0.00001; r = -0.457, p < 0.00001; mean diffusivity r = -0.341, p = 0.0016; radial diffusivity r = -0.457, p < 0.00001) and NODDI parameters (intracellular volume fraction r = 0.364, p = 0.0007) in widespread regions. CONCLUSION: Our results extend previous reports of impairment that is independent of presence of infarction and may worsen with age. We identify processing speed as a vulnerable domain, with deficits potentially mediating difficulties across other domains, and provide evidence that reduced processing speed is related to the integrity of normal-appearing white matter using microstructure parameters from DTI and NODDI.

JOURNAL ARTICLE

Brewin J, Kaya B, Chakravorty S, 2017, How I manage sickle cell patients with high transcranial doppler results., Br J Haematol, Vol: 179, Pages: 377-388

Stroke is one of the most severe complications to affect children with sickle cell anaemia (SCA). Transcranial doppler (TCD) is an accurate and non-invasive method to determine stroke risk. Randomised controlled trials have demonstrated the efficacy of chronic transfusion therapy in stroke prevention based on risk stratification determined by TCD velocities. This has led to the regular use of TCD monitoring for children with SCA in order to determine stroke risk. Significant resource allocation is necessary to facilitate training, quality assurance and failsafe arrangements for non-attenders. In a subgroup of patients, chronic transfusions for primary stroke prevention can be replaced by hydroxycarbamide therapy, provided careful monitoring is undertaken; including repeat TCD studies at frequent intervals. The authors propose an evidence-based algorithm for the management of abnormal TCD velocities and discuss the role of this test in other clinical contexts, such as in Haemoglobin SC disease.

JOURNAL ARTICLE

Greenwood S, Deane C, Rees OL, Freedman B, Kumar S, Ben Ramadan N, Wilkinson S, Marais G, Lord J, Chakravorty S, Height SE, Gardner K, Rees DCet al., 2017, The significance of inadequate transcranial Doppler studies in children with sickle cell disease, PLOS ONE, Vol: 12, ISSN: 1932-6203

JOURNAL ARTICLE

Piel FB, Tewari S, Brousse V, Analitis A, Font A, Menzel S, Chakravorty S, Thein SL, Inusa B, Telfer P, de Montalembert M, Fuller GW, Katsouyanni K, Rees DCet al., 2017, Associations between environmental factors and hospital admissions for sickle cell disease, HAEMATOLOGICA, Vol: 102, Pages: 666-675, ISSN: 0390-6078

JOURNAL ARTICLE

Bain BJ, Chakravorty S, 2016, Phytosterolemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 91, Pages: 643-643, ISSN: 0361-8609

JOURNAL ARTICLE

Chakravorty S, Tallett A, Sathyamoorthy G, James Jet al., 2016, USING A NEW PATIENT FEEDBACK SURVEY TO EXPLORE EXPERIENCES OF LIVING WITH SICKLE CELL DISEASE IN THE UK, Publisher: OXFORD UNIV PRESS, Pages: 60-61, ISSN: 1353-4505

CONFERENCE PAPER

Fordham NJ, Ajitsaria R, Karnik L, Chakravorty Set al., 2016, Haemophagocytic Lymphohistiocytosis responding to withdrawal of gluten: a case report, Journal of Medical Case Reports, Vol: 10, ISSN: 1752-1947

IntroductionThis is the first documented case of a patient with Haemophagocytic Lymphohistiocytosis (HLH) in association with coeliac disease. There was complete clinical and biochemical remission of HLH following the introduction of a gluten free diet.Case presentationA seven-year old Caucasian girl presented with fevers, maculopapular rash with a recent history of tonsillitis. Blood tests revealed thrombocytopenia (64 x 109/L), anaemia (80g/L), hypofibrinogenaemia (1g/L) and hyperferritinaemia (71378µg/L). A bone marrow revealed evidence of haemophagocytosis, but tests for the genetic or familial associated HLH syndromes were negative. Screening tests for known secondary causes was negative. She was diagnosed with HLH, and following treatment with the HLH-2004 protocol these symptoms, in addition to the biochemical and haematological markers completely resolved. The patient presented again ten months later with fever, rash, and biochemical abnormalities suggestive of HLH. Tissue transglutamase was markedly raised and blood tests revealed a genetic susceptibly to coeliac disease in the form of HLA DQ2 positivity. She commenced a gluten free diet and there was complete symptomatic and biochemical response without any further chemotherapy. She had further episodic rashes, each associated with the accidental intake of gluten. ConclusionThis is to our knowledge the first documented case of HLH in association with coeliac disease. There was no other secondary cause found; she initially responded to chemo-immunotherapy specific for HLH but relapsed within a few months of cessation of treatment and then achieved complete remission on gluten withdrawal alone.

JOURNAL ARTICLE

Tewari S, Piel F, Brousse V, Analitis A, Ghersi V, Menzel S, Chakravorty S, Inusa B, Telfer P, De Montalembert M, Fuller G, Katsouyanni K, Rees Det al., 2016, ASSOCIATION BETWEEN ENVIRONMENTAL FACTORS AND HOSPITAL ADMISSIONS FOR SICKLE CELL DISEASE: A RETROSPECTIVE TIME SERIES ANALYSIS, 21st Congress of the European-Hematology-Association, Publisher: FERRATA STORTI FOUNDATION, Pages: 127-128, ISSN: 0390-6078

CONFERENCE PAPER

Bain BJ, Chakravorty S, Ancliff P, 2015, Congenital acute megakaryoblastic leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 963-963, ISSN: 0361-8609

JOURNAL ARTICLE

Chakravorty S, Tallett A, Hay H, Chisholm A, Warner J, Sathyamoorthy G, James Jet al., 2015, Assessing the care experiences of people living with sickle cell disease to inform the development of a patient reported experience measure (PREM), 55th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL, Pages: 25-26, ISSN: 0007-1048

CONFERENCE PAPER

Chakravorty S, Williams TN, 2015, Sickle cell disease: a neglected chronic disease of increasing global health importance, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 100, Pages: 48-53, ISSN: 0003-9888

JOURNAL ARTICLE

Evans C, Orf K, Horvath E, Levin M, De La Fuente J, Chakravorty S, Cunnington AJet al., 2015, Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1, HAEMATOLOGICA, Vol: 100, Pages: 1508-1516, ISSN: 0390-6078

JOURNAL ARTICLE

Lund K, Chakravorty S, Toma S, Bain BJet al., 2015, Compound heterozygosity for hemoglobins S and D, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 842-842, ISSN: 0361-8609

JOURNAL ARTICLE

O'Boyle F, Hing S, Harrington Y, Chakravorty S, Karnik L, New H, Bradshaw A, Szydlo R, de la Fuente Jet al., 2015, Fludarabine/Treosulfan/Thiotepa/ATG Conditioning for Related Transplantation in Haemoglobinopathies Leads to Early and Sustanined Engraftment with Low Incidence of VOD and GvHD, 57th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Portsmore S, Chakravorty S, Oppong E, Ahmad R, Bain BJet al., 2015, Systemic EBV-positive lymphoproliferative disease of childhood, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 355-355, ISSN: 0361-8609

JOURNAL ARTICLE

Portsmore S, Chakravorty S, Oppong E, Ahmad R, Bain BJet al., 2015, Systemic EBV-positive lymphoproliferative disease of childhood (vol 90, pg 355, 2015), AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 849-849, ISSN: 0361-8609

JOURNAL ARTICLE

Thompson J, Mkandawire C, Chakravorty S, Laffan Met al., 2015, A Pilot Study of Assessing Cognition in Children with Sickle Cell Disease Using a New Software Package the Cogstate Battery, 57th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

de la Fuente J, O'Boyle F, Harrington Y, Bradshaw A, Hind S, Chakravorty S, Karnik L, New H, Szydlo R, Inusa BPD, Telfer Pet al., 2015, Haploidentical BMT with a Post-Infusion of Stem Cells Cyclophosphamide Approach Is Feasible and Leads to a High Rate of Donor Engraftment in Haemoglobinopathies Allowing Universal Application of Transplantation, 57th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

de la Fuente J, Chakravorty S, Ayres R, Mkandawire Cet al., 2014, A Survey of the Management of Acute Chest Syndrome in Children with Sickle Cell Disease in Centres in UK and Western Europe, 56th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Baki Y, Chakravorty S, Bridges N, Karnik L, Roberts I, de la Fuente J, Moyo Y, Alexander Set al., 2013, Endocrine late effects post-haematopoietic stem cell transplant (HSCT) in children with haemoglobinopathies, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S373-S374, ISSN: 0268-3369

CONFERENCE PAPER

Jessen B, Bode SFN, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl WA, Gochuico BR, Griese M, Griffiths G, Janka G, Klein C, Koegl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford AD, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu GT, Zieger B, zur Stadt U, Aichele P, Ehl Set al., 2013, The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2, BLOOD, Vol: 121, Pages: 2943-2951, ISSN: 0006-4971

JOURNAL ARTICLE

Jones ML, Murden SL, Brooks C, Maloney V, Manning RA, Gilmour KC, Bharadwaj V, de la Fuente J, Chakravorty S, Mumford ADet al., 2013, Disruption of AP3B1 by a chromosome 5 inversion: a new disease mechanism in Hermansky-Pudlak syndrome type 2, BMC MEDICAL GENETICS, Vol: 14, ISSN: 1471-2350

JOURNAL ARTICLE

Bharadwaj V, Chakravorty S, Bain BJ, 2012, The cause of sudden anemia revealed by the blood film, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 520-520, ISSN: 0361-8609

JOURNAL ARTICLE

Chakravorty S, King MJ, Bain BJ, 2012, An unexpectedly bizarre blood film in hemoglobin H disease, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 1104-1104, ISSN: 0361-8609

JOURNAL ARTICLE

Chakravorty S, Roberts I, 2012, How I manage neonatal thrombocytopenia, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 156, Pages: 155-162, ISSN: 0007-1048

JOURNAL ARTICLE

Collier E, de la Fuente J, Chakravorty S, 2012, Prevalence and Effect of Coagulation Defects in Children Undergoing Bone Marrow Transplantation for Haemoglobinopathies., 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Ong M, Daly P, Chakravorty S, Roberts IAG, de la Fuente Jet al., 2012, Automated exchange transfusions for sickle cell disease are safe and feasible using peripheral access in the paediatric population, 52nd Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL, Pages: 72-72, ISSN: 0007-1048

CONFERENCE PAPER

Bhatnagar N, Erskine R, O'Boyle F, Chakravorty S, Roberts I, de la Fuente Jet al., 2011, Bone Marrow Transplantation Arrests Cerebrovascular Disease Progression and Improves Psychometric Outcomes in Children with Sickle Cell Disease, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 10-10, ISSN: 0006-4971

CONFERENCE PAPER

Bain BJ, Murray JA, Patterson KG, Chakravorty S, Ancliff P, Wong CC, Hann I, Wong C, Philpott N, Bolam S, Thomas Wet al., 2005, Slide session, British Society for Haematology, 45th Annual Scientific Meeting, Manchester, 2005, CLINICAL AND LABORATORY HAEMATOLOGY, Vol: 27, Pages: 363-369, ISSN: 0141-9854

JOURNAL ARTICLE

Chakravorty S, Murray N, Roberts I, 2005, Neonatal thrombocytopenia, EARLY HUMAN DEVELOPMENT, Vol: 81, Pages: 35-41, ISSN: 0378-3782

JOURNAL ARTICLE

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