Publications
67 results found
de la Fuente J, O'Boyle F, Harrington Y, et al., 2015, Haploidentical BMT with a Post-Infusion of Stem Cells Cyclophosphamide Approach Is Feasible and Leads to a High Rate of Donor Engraftment in Haemoglobinopathies Allowing Universal Application of Transplantation, 57th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
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- Citations: 17
O'Boyle F, Hing S, Harrington Y, et al., 2015, Fludarabine/Treosulfan/Thiotepa/ATG Conditioning for Related Transplantation in Haemoglobinopathies Leads to Early and Sustanined Engraftment with Low Incidence of VOD and GvHD, 57th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Bain BJ, Chakravorty S, Ancliff P, 2015, Congenital acute megakaryoblastic leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 963-963, ISSN: 0361-8609
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- Citations: 5
Portsmore S, Chakravorty S, Oppong E, et al., 2015, Systemic EBV-positive lymphoproliferative disease of childhood (vol 90, pg 355, 2015), AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 849-849, ISSN: 0361-8609
Lund K, Chakravorty S, Toma S, et al., 2015, Compound heterozygosity for hemoglobins S and D, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 842-842, ISSN: 0361-8609
Evans C, Orf K, Horvath E, et al., 2015, Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1, Haematologica - the Hematology Journal, Vol: 100, Pages: 1508-1516, ISSN: 0390-6078
Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during granulopoiesis, impairing the ability of developing neutrophils to mount a bactericidal oxidative burst, and increasing susceptibility to bacterial infection. We hypothesised that this may also occur with the chronic hemolysis of sickle cell disease, potentially contributing to susceptibility to infections. We found that neutrophil oxidative burst activity was significantly lower in treatment-naive children with sickle cell disease compared to age-, gender- and ethnicity-matched controls, whilst degranulation was similar. The defect in neutrophil oxidative burst was quantitatively related to both systemic heme oxygenase-1 activity (assessed by carboxyhemoglobin concentration) and neutrophil mobilization. A distinct population of heme oxygenase-1-expressing cells was present in the bone marrow of children with sickle cell disease, but not in healthy children, with a surface marker profile consistent with neutrophil progenitors (CD49dHi CD24Lo CD15Int CD16Int CD11b+/-). Incubation of promyelocytic HL-60 cells with the heme oxygenase-1 substrate and inducer, hemin, demonstrated that heme oxygenase-1 induction during neutrophilic differentiation could reduce oxidative burst capacity. These findings indicate that impairment of neutrophil oxidative burst activity in sickle cell disease is associated with hemolysis and heme oxygenase-1 expression. Neutrophil dysfunction might contribute to risk of infection in sickle cell disease, and measurement of neutrophil oxidative burst might be used to identify patients at greatest risk of infection, who might benefit from enhanced prophylaxis.
Chakravorty S, Tallett A, Hay H, et al., 2015, Assessing the care experiences of people living with sickle cell disease to inform the development of a patient reported experience measure (PREM), 55th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL, Pages: 25-26, ISSN: 0007-1048
Portsmore S, Chakravorty S, Oppong E, et al., 2015, Systemic EBV-positive lymphoproliferative disease of childhood, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 355-355, ISSN: 0361-8609
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- Citations: 3
Chakravorty S, Williams TN, 2015, Sickle cell disease: A neglected chronic disease of increasing global health importance, Archives of Disease in Childhood, Vol: 100, Pages: 48-53
de la Fuente J, Chakravorty S, Ayres R, et al., 2014, A Survey of the Management of Acute Chest Syndrome in Children with Sickle Cell Disease in Centres in UK and Western Europe, 56th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Katsarou A, Harrington Y, O'Boyle F, et al., 2014, REDUCED INTENSITY CONDITIONING HAPLOIDENTICAL BONE MARROW TRANSPLANTATION WITH A POST-INFUSION CYCLOPHOSPHAMIDE APPROACH IS FEASIBLE AND ENABLES FULL DONOR ENGRAFTMENT FOR CHILDREN SUFFERING FROM SICKLE CELL DISEASE, 40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S375-S375, ISSN: 0268-3369
Bradshaw A, Dazzi F, Marley S, et al., 2014, MESENCHYMAL STROMAL CELLS FOR THE TREATMENT OF GRAFT VERSUS HOST DISEASE IN PATIENTS WITH CONCOMITANT INFECTION, 40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S535-S535, ISSN: 0268-3369
Chakravorty S, Roberts I, 2014, Neonatal Thrombocytopenia, CONTROVERSIES IN PEDIATRIC AND ADOLESCENT HEMATOLOGY, Editors: Thomas, Halsey, Publisher: KARGER, Pages: 1-15, ISBN: 978-3-318-02422-7
de la Fuente J, O'Boyle F, Harrington Y, et al., 2013, Fludarabine/Treosulfan/Thiotepa/ATG Conditioning Leads To High Rates Of Long-Term Engraftment and Low Toxicity Enabling The Use Of Mismatched and Unrelated Donors For Transplantation In Haemoglobinopathies, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
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- Citations: 1
Roberts IAG, Chakravorty S, 2013, Thrombocytopenia in the Newborn, Platelets, Pages: 929-951, ISBN: 9780123878373
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- Citations: 3
Jessen B, Bode SFN, Ammann S, et al., 2013, The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2, BLOOD, Vol: 121, Pages: 2943-2951, ISSN: 0006-4971
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- Citations: 49
Jones ML, Murden SL, Brooks C, et al., 2013, Disruption of <i>AP3B1</i> by a chromosome 5 inversion: a new disease mechanism in Hermansky-Pudlak syndrome type 2, BMC MEDICAL GENETICS, Vol: 14
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- Citations: 21
Baki Y, Chakravorty S, Bridges N, et al., 2013, Endocrine late effects post-haematopoietic stem cell transplant (HSCT) in children with haemoglobinopathies, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S373-S374, ISSN: 0268-3369
Chakravorty S, King MJ, Bain BJ, 2012, An unexpectedly bizarre blood film in hemoglobin H disease, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 1104-1104, ISSN: 0361-8609
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- Citations: 1
Collier E, de la Fuente J, Chakravorty S, 2012, Prevalence and Effect of Coagulation Defects in Children Undergoing Bone Marrow Transplantation for Haemoglobinopathies., 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Bharadwaj V, Chakravorty S, Bain BJ, 2012, The cause of sudden anemia revealed by the blood film, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 520-520, ISSN: 0361-8609
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- Citations: 2
Ong M, Daly P, Chakravorty S, et al., 2012, Automated exchange transfusions for sickle cell disease are safe and feasible using peripheral access in the paediatric population, 52nd Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL, Pages: 72-72, ISSN: 0007-1048
Chakravorty S, Roberts I, 2012, How I manage neonatal thrombocytopenia, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 156, Pages: 155-162, ISSN: 0007-1048
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- Citations: 48
Bhatnagar N, Erskine R, O'Boyle F, et al., 2011, Bone Marrow Transplantation Arrests Cerebrovascular Disease Progression and Improves Psychometric Outcomes in Children with Sickle Cell Disease, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 10-10, ISSN: 0006-4971
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- Citations: 1
Chakravorty S, Hann IM, 2007, Management of Infection in Children with Bone Marrow Failure, Pediatric Hematology: Third Edition, Pages: 745-754, ISBN: 9781405134002
Telfer P, Coen P, Chakravorty S, et al., 2007, Clinical outcomes in children with sickle cell disease living in England: a neonatal cohort in East London., Haematologica, Vol: 92, Pages: 905-912
BACKGROUND AND OBJECTIVES: We investigated outcomes in a UK neonatal cohort as a benchmark for care of children with sickle cell disease (SCD). DESIGN AND METHODS: Two-hundred and fifty-two children (180 with hemoglobin [Hb] SS, 64 with HbSC, and 8 with HbS/beta thalassemia), identified during 1983-2005 by universal birth screening in East London, were followed in a hospital and community-based program which included penicillin V prophylaxis from 3 months of age, 23-valent pneumococcal polysaccharide vaccine from 1993, conjugate pneumococcal vaccine from 2002 and transcranial Doppler screening from 1991. RESULTS: At the end of 2005, there were 2158 patient years of observation. The median age of the patients was 7.8 (interquartile range 3.3-13.0) years, and 2.8% of those enrolled had been lost to follow-up. The estimated survival of children with HbSS at 16 years was 99.0% (95% confidence interval, CI, 93.2 to 99.9%) and pneumococcal sepsis rate was 0.3 (95% CI 0.1-0.8) episodes per 100 patient-years. The risk of overt stroke was 4.3% (95%CI 1.5 to 11.4%) and could be further reduced by transcranial Doppler screening from infancy and transfusing all children with high-risk scans. No deaths, strokes or episodes of pneumococcal sepsis were observed in children with HbSC or HbS/beta thalassemia. The mortality rates from HbSS were significantly lower than those in other reported cohorts. INTERPRETATION AND CONCLUSIONS: Mortality in childhood SCD can virtually be eliminated in a well-resourced health service setting linking community-based care with a specialized, hospital-based center. SCD continues to cause substantial morbidity from acute complications and chronic organ damage. We recommend setting up of clinical networks to optimize the management of SCD.
Bain BJ, Murray JA, Patterson KG, et al., 2005, Slide session, British Society for Haematology, 45th Annual Scientific Meeting, Manchester, 2005, CLINICAL AND LABORATORY HAEMATOLOGY, Vol: 27, Pages: 363-369, ISSN: 0141-9854
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- Citations: 1
Chakravorty S, Murray N, Roberts I, 2005, Neonatal thrombocytopenia, EARLY HUMAN DEVELOPMENT, Vol: 81, Pages: 35-41, ISSN: 0378-3782
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- Citations: 41
Chakravorty S, Newell K, Ramchandani J, et al., 2004, Sickle cell disease pain in London and the Caribbean., Arch Dis Child, Vol: 89, Pages: 272-273
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