Imperial College London
Alternate

DrSubarnaChakravorty

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3299 3773s.chakravorty

 
 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brewin:2017:10.1111/bjh.14850,
author = {Brewin, J and Kaya, B and Chakravorty, S},
doi = {10.1111/bjh.14850},
journal = {Br J Haematol},
pages = {377--388},
title = {How I manage sickle cell patients with high transcranial doppler results.},
url = {http://dx.doi.org/10.1111/bjh.14850},
volume = {179},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Stroke is one of the most severe complications to affect children with sickle cell anaemia (SCA). Transcranial doppler (TCD) is an accurate and non-invasive method to determine stroke risk. Randomised controlled trials have demonstrated the efficacy of chronic transfusion therapy in stroke prevention based on risk stratification determined by TCD velocities. This has led to the regular use of TCD monitoring for children with SCA in order to determine stroke risk. Significant resource allocation is necessary to facilitate training, quality assurance and failsafe arrangements for non-attenders. In a subgroup of patients, chronic transfusions for primary stroke prevention can be replaced by hydroxycarbamide therapy, provided careful monitoring is undertaken; including repeat TCD studies at frequent intervals. The authors propose an evidence-based algorithm for the management of abnormal TCD velocities and discuss the role of this test in other clinical contexts, such as in Haemoglobin SC disease.
AU  - Brewin,J
AU  - Kaya,B
AU  - Chakravorty,S
DO  - 10.1111/bjh.14850
EP  - 388
PY  - 2017///
SP  - 377
TI  - How I manage sickle cell patients with high transcranial doppler results.
T2  - Br J Haematol
UR  - http://dx.doi.org/10.1111/bjh.14850
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28771666
VL  - 179
ER  -
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