Imperial College London

ProfessorStephenCurry

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 7632s.curry Website

 
 
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Assistant

 

Mrs Faaria Henry +44 (0)20 7594 1175

 
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Location

 

404ASir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

117 results found

Hatch A, Curry S, 2018, Evaluation woes: We're on it, responds DORA, Nature, Vol: 559, ISSN: 0028-0836

JOURNAL ARTICLE

Newman J, Asfor AS, Berryman S, Jackson T, Curry S, Tuthill TJet al., 2018, The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers, JOURNAL OF VIROLOGY, Vol: 92, ISSN: 0022-538X

JOURNAL ARTICLE

Fyfe A, Coate K, Curry S, Lawson S, Moxham N, Røstvik CMet al., 2017, Untangling Academic Publishing: A history of the relationship between commercial interests, academic prestige and the circulation of research

In 2013, the UK Arts and Humanities Research Council funded a 4-year project onthe editorial and commercial history of the world’s oldest-surviving scholarly journal(‘Publishing the Philosophical Transactions: a social, cultural and economic history ofa learned journal, 1665-2015’, AH/K001841). The project is led by Dr Aileen Fyfe at theUniversity of St Andrews in partnership with the Royal Society.The project team convened a workshop at the Royal Society, 22 April 2016, on ‘The Politicsof Academic Publishing, 1950-2016’. This briefing paper is informed by the contributionsof those who attended that day, and we thank them for their insights. The authors of thisbriefing paper are a sub-group of those who attended the April 2016 workshop.This report is based upon the primary (historical) research of the PhilosophicalTransactions project team, combined with a literature review, and the expertise of the otherauthors (principally in higher education research, and in scholarly communication).

REPORT

Li T-F, Hosmillo M, Schwanke H, Shu T, Wang Z, Yin L, Curry S, Goodfellow IG, Zhou Xet al., 2017, Human Norovirus NS3 has RNA Helicase and Chaperoning Activities., Journal of Virology, Vol: 92, ISSN: 1098-5514

RNA remodeling proteins, including RNA helicases and chaperones, act to remodel RNA structures and/or protein-RNA interactions, and are required for all processes involving RNAs. Although many viruses encode RNA helicases and chaperones, their in vitro activities and their roles in infected cells largely remain elusive. Noroviruses are a diverse group of positive-stranded RNA viruses in the family Caliciviridae, and constitute a significant and potentially fatal threat to human health. Here we report that protein NS3 encoded by human norovirus has both ATP-dependent RNA helicase activity that unwinds RNA helices and ATP-independent RNA chaperoning activity that can remodel structured RNAs and facilitate strand-annealing. Moreover, NS3 can facilitate viral RNA synthesis in vitro by norovirus polymerase. NS3 may therefore play an important role in norovirus RNA replication. Lastly, we demonstrate that the RNA remodeling activity of NS3 is inhibited by guanidine hydrochloride, an FDA-approved compound and, more importantly, that it reduces the replication of norovirus replicon in cultured human cells. Altogether, these findings are the first to demonstrate the presence of RNA remodeling activities encoded by Caliciviridae, and highlight the functional significance of NS3 in noroviral life cycle.IMPORTANCE Noroviruses are a diverse group of positive-stranded RNA viruses, which annually cause hundreds of millions of human infections and over 200,000 deaths worldwide. For RNA viruses, cellular or virus-encoded RNA helicases and/or chaperones have long been considered to play pivotal roles in viral life cycles. However, neither RNA helicase nor chaperoning activity has been demonstrated to associate with any norovirus-encoded proteins, and it is also unknown whether norovirus replication requires the participation of any viral or cellular RNA helicases/chaperones. We found that a norovirus protein NS3 not only has ATP-dependent helicase activity, but also acts as an ATP-in

JOURNAL ARTICLE

Curry S, 2016, Perspectives: It's time for positive action on negative results, Chemical and Engineering News, Vol: 94, Pages: 34-35, ISSN: 0009-2347

JOURNAL ARTICLE

Curry S, 2016, What is the meaning of Brexit?, EMBO Rep, Vol: 17, Pages: 1239-1240

JOURNAL ARTICLE

Curry S, Rohn J, Steele A, 2016, UK research reform: protest now, Publisher: NATURE PUBLISHING GROUP

OTHER

Hosmillo M, Sweeney TR, Chaudhry Y, Leen E, Curry S, Goodfellow I, Cho K-Oet al., 2016, The RNA Helicase eIF4A Is Required for Sapovirus Translation, JOURNAL OF VIROLOGY, Vol: 90, Pages: 5200-5204, ISSN: 0022-538X

JOURNAL ARTICLE

Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry Set al., 2016, A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation, PLOS PATHOGENS, Vol: 12, ISSN: 1553-7366

JOURNAL ARTICLE

Yang J, Leen EN, Maree FF, Curry Set al., 2016, Crystal structure of the 3C protease from South African Territories type 2 foot-and-mouth disease virus, Publisher: PeerJ Preprints

The replication of foot-and-mouth disease virus (FMDV) is dependent on the virus-encoded 3C protease (3Cpro). As in other picornaviruses, 3Cpro performs most of the proteolytic processing of the polyprotein expressed from the single open reading frame in the RNA genome of the virus. Previous work revealed that the 3Cpro from serotype A – one of the seven serotypes of FMDV – adopts a trypsin-like fold. Phylogenetically the FMDV serotypes are grouped into two clusters, with O, A, C, and Asia 1 in one, and the three South African Territories serotypes, (SAT-1, SAT-2 and SAT-3) in another. We report here the cloning, expression and purification of 3C proteases from four SAT serotype viruses (SAT2/GHA/8/91, SAT1/NIG/5/81, SAT1/UGA/1/97, and SAT2/ZIM/7/83) and the crystal structure at 3.2 Å resolution of 3Cpro from SAT2/GHA/8/91).

REPORT

Yang J, Leen EN, Maree FF, Curry Set al., 2016, Crystal structure of the 3C protease from Southern African Territories type foot-and-mouth disease virus 2, PEERJ, Vol: 4, ISSN: 2167-8359

JOURNAL ARTICLE

Curry S, 2015, Structural Biology: A Century-long Journey into an Unseen World, INTERDISCIPLINARY SCIENCE REVIEWS, Vol: 40, Pages: 308-328, ISSN: 0308-0188

JOURNAL ARTICLE

Fernandes H, Leen EN, Cromwell H, Pfeil M-P, Curry Set al., 2015, Structure determination of Murine Norovirus NS6 proteases with C-terminal extensions designed to probe protease-substrate interactions, PEERJ, Vol: 3, ISSN: 2167-8359

JOURNAL ARTICLE

Chung L, Bailey D, Leen EN, Emmott EP, Chaudhry Y, Roberts LO, Curry S, Locker N, Goodfellow IGet al., 2014, Norovirus Translation Requires an Interaction between the C Terminus of the Genome-linked Viral Protein VPg and Eukaryotic Translation Initiation Factor 4G, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 289, Pages: 21738-21750, ISSN: 0021-9258

JOURNAL ARTICLE

Curry S, 2014, Open access - reasons to be cheerful: a reply to Agrawal, TRENDS IN PLANT SCIENCE, Vol: 19, Pages: 196-197, ISSN: 1360-1385

JOURNAL ARTICLE

Joshi A, Esteve V, Buckroyd AN, Blatter M, Allain FH-T, Curry Set al., 2014, Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB), PEERJ, Vol: 2, ISSN: 2167-8359

JOURNAL ARTICLE

Mickleburgh I, Kafasla P, Cherny D, Llorian M, Curry S, Jackson RJ, Smith CWJet al., 2014, The organization of RNA contacts by PTB for regulation of FAS splicing, NUCLEIC ACIDS RESEARCH, Vol: 42, Pages: 8605-8620, ISSN: 0305-1048

JOURNAL ARTICLE

Rosell NRR, Mokhlesi L, Milton NE, Sweeney TR, Zunszain PA, Curry S, Leatherbarrow RJet al., 2014, Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 24, Pages: 490-494, ISSN: 0960-894X

JOURNAL ARTICLE

Curry S, 2013, Open access: Brave new world requires bravery, Insights: the UKSG Journal, Vol: 26, Pages: 22-27

The year 2012 heralded significant developments in open access (OA) that impacted the relationships between the major stakeholders in scholarly publishing: researchers, funders, publishers and governments. In the UK, the clear preference for a gold OA policy enunciated by the government-backed 'Finch Report' is now being implemented by the research councils. Although the policy has been modified to include green routes to OA publishing, arguments continue about the optimal route to a system of open access that can work on a global scale. Resolution of these disputes will require courage and imagination.

JOURNAL ARTICLE

Leen EN, Kwok KYR, Birtley JR, Simpson PJ, Subba-Reddy CV, Chaudhry Y, Sosnovtsev SV, Green KY, Prater SN, Tong M, Young JC, Chung LMW, Marchant J, Roberts LO, Kao CC, Matthews S, Goodfellow IG, Curry Set al., 2013, Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins, JOURNAL OF VIROLOGY, Vol: 87, Pages: 5318-5330, ISSN: 0022-538X

JOURNAL ARTICLE

Porta C, Xu X, Loureiro S, Paramasivam S, Ren J, Al-Khalil T, Burman A, Jackson T, Belsham GJ, Curry S, Lomonossoff GP, Parida S, Paton D, Li Y, Wilsden G, Ferris N, Owens R, Kotecha A, Fry E, Stuart DI, Charleston B, Jones IMet al., 2013, Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity, JOURNAL OF VIROLOGICAL METHODS, Vol: 187, Pages: 406-412, ISSN: 0166-0934

JOURNAL ARTICLE

Zhou Z, Mogensen MM, Powell PP, Curry S, Wileman Tet al., 2013, Foot-and-Mouth Disease Virus 3C Protease Induces Fragmentation of the Golgi Compartment and Blocks Intra-Golgi Transport, JOURNAL OF VIROLOGY, Vol: 87, Pages: 11721-11729, ISSN: 0022-538X

JOURNAL ARTICLE

Curry S, 2012, By the people, for the people, New Scientist, Vol: 214, Pages: 26-27, ISSN: 0262-4079

JOURNAL ARTICLE

Curry S, 2012, Access all areas, NEW SCIENTIST, Vol: 214, Pages: 26-27, ISSN: 0262-4079

JOURNAL ARTICLE

Curry S, 2012, Access all areas, NEW SCIENTIST, Vol: 214, Pages: 26-27, ISSN: 0262-4079

JOURNAL ARTICLE

Kafasla P, Mickleburgh I, Llorian M, Coelho M, Gooding C, Cherny D, Joshi A, Kotik-Kogan O, Curry S, Eperon IC, Jackson RJ, Smith CWJet al., 2012, Defining the roles and interactions of PTB, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 40, Pages: 815-820, ISSN: 0300-5127

JOURNAL ARTICLE

Leen EN, Baeza G, Curry S, 2012, Structure of a Murine Norovirus NS6 Protease-Product Complex Revealed by Adventitious Crystallisation, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

Martino L, Pennell S, Kelly G, Bui TTT, Kotik-Kogan O, Smerdon SJ, Drake AF, Curry S, Conte MRet al., 2012, Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein, NUCLEIC ACIDS RESEARCH, Vol: 40, Pages: 1381-1394, ISSN: 0305-1048

JOURNAL ARTICLE

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