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@article{Hosmillo:2016:10.1128/JVI.03174-15,
author = {Hosmillo, M and Sweeney, TR and Chaudhry, Y and Leen, E and Curry, S and Goodfellow, I and Cho, K-O},
doi = {10.1128/JVI.03174-15},
journal = {Journal of Virology},
pages = {5200--5204},
title = {The RNA Helicase eIF4A Is Required for Sapovirus Translation},
url = {http://dx.doi.org/10.1128/JVI.03174-15},
volume = {90},
year = {2016}
}

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TY  - JOUR
AB  - The eukaryotic initiation factor 4A (eIF4A) is a DEAD box helicase that unwinds RNA structure in the 5′ untranslated region (UTR) of mRNAs. Here, we investigated the role of eIF4A in porcine sapovirus VPg-dependent translation. Using inhibitors and dominant-negative mutants, we found that eIF4A is required for viral translation and infectivity, suggesting that despite the presence of a very short 5′ UTR, eIF4A is required to unwind RNA structure in the sapovirus genome to facilitate virus translation.
AU  - Hosmillo,M
AU  - Sweeney,TR
AU  - Chaudhry,Y
AU  - Leen,E
AU  - Curry,S
AU  - Goodfellow,I
AU  - Cho,K-O
DO  - 10.1128/JVI.03174-15
EP  - 5204
PY  - 2016///
SN  - 1098-5514
SP  - 5200
TI  - The RNA Helicase eIF4A Is Required for Sapovirus Translation
T2  - Journal of Virology
UR  - http://dx.doi.org/10.1128/JVI.03174-15
UR  - http://hdl.handle.net/10044/1/34220
VL  - 90
ER  -

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