Imperial College London

Dr Sara De Matteis

Faculty of MedicineNational Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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s.de-matteis

 
 
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G51Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

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139 results found

Mukhopadhyay D, Cocco P, Orrù S, Cherchi R, De Matteis Set al., 2024, The role of MicroRNAs as early biomarkers of asbestos-related lung cancer: A systematic review and meta-analysis., Pulmonology

BACKGROUND: Asbestos is still the leading cause of occupational cancer mortality worldwide. Asbestos-related lung cancer (LC) and malignant pleural mesothelioma (MPM) prognosis is still poor especially at advanced stage, so early diagnosis biomarkers are needed. MicroRNAs (miRNAs) have been proposed as potential early diagnostic biomarkers of asbestos-related LC and MPM. AIM: To evaluate the role of miRNAs as diagnostic and prognostic biomarkers of asbestos-related LC and MPM by performing a literature systematic review and meta-analysis. METHODS: MEDLINE, EMBASE via Ovid, PUBMED and Cochrane library databases were systematically searched up to April 2023 to identify relevant articles. A grey literature search was also conducted using the Google Scholar platform. MeSH and free text terms for 'asbestos', 'occupational exposure', 'lung cancer', 'mesothelioma' and 'miRNAs' were used to search the literature. Our systematic review protocol was registered in the PROSPERO database. Study quality was assessed via the Newcastle-Ottawa Scale. RESULTS: From the search, 331 articles were retrieved, and, after applying our selection criteria, and exclusion of one study for poor quality, 27 studies were included in the review. Most of the studies were hospital-based case-control, conducted in Europe, and evaluated MPM among men only. MiRNAs expression was measured mainly in plasma or serum. MiR-126, miR-132-3p, and miR-103a-3p were the most promising diagnostic biomarkers for MPM, and we estimated a pooled area under the curve (AUC) of 85 %, 73 %, and 50 %, respectively. In relation to MPM prognosis, miR-197‑3p resulted associated with increased survival time. MiR-126, alone and combined with miR-222, was confirmed associated also to LC diagnosis, together with miR-1254 and miR-574-5p; no miRNA was found associated to LC prognosis. CONCLUSION: Based on our systematic literature review there is suggestive evidence that the expression of specific miRNAs in the blood serum or plasm

Journal article

Nafees AA, Allana A, Kadir MM, Potts J, Minelli C, Semple S, De Matteis S, Burney P, Cullinan Pet al., 2024, A cluster randomised controlled trial to reduce respiratory effects of cotton dust exposure among textile workers: the MultiTex RCT study., Eur Respir J, Vol: 63

BACKGROUND: We determined the effectiveness of an intervention to reduce cotton dust-related respiratory symptoms and improve lung function of textile workers. METHODS: We undertook a cluster randomised controlled trial at 38 textile mills in Karachi, Pakistan. The intervention comprised: training in occupational health for workers and managers, formation of workplace committees to promote a health and safety plan that included wet mopping and safe disposal of cotton dust, provision of simple face masks, and further publicity about the risks from cotton dust. Participating mills were randomised following baseline data collection. The impact of the intervention was measured through surveys at 3, 12 and 18 months using questionnaires, spirometry and dust measurements. The primary outcomes were 1) changes in prevalence of a composite respiratory symptom variable, 2) changes in post-bronchodilator percentage predicted forced expiratory volume in 1 s (FEV1) and 3) changes in cotton dust levels. These were assessed using two-level mixed effects linear and logistic regression. RESULTS: Of 2031 participants recruited at baseline, 807 (40%) were available at the third follow-up. At that point, workers in the intervention arm were more likely to report an improvement in respiratory symptoms (OR 1.58, 95% CI 1.06-2.36) and lung function (FEV1 % pred: β 1.31%, 95% CI 0.04-2.57%). Personal dust levels decreased, more so in intervention mills, although we did not observe this in adjusted models due to the small number of samples. CONCLUSION: We found the intervention to be effective in improving the respiratory health of textile workers and recommend scaling-up of such simple and feasible interventions in low- and middle-income countries.

Journal article

De Matteis S, 2023, Indoor Air Pollution and Lung Function Decline: "Should I Stay or Should I Go?"., Am J Respir Crit Care Med, Vol: 208, Pages: 1009-1012

Journal article

Veronesi G, Ferrario MM, Giusti EM, Borchini R, Cimmino L, Ghelli M, Banfi A, Luoni A, Persechino B, Di Tecco C, Ronchetti M, Gianfagna F, De Matteis S, Castelnuovo G, Iacoviello Let al., 2023, Systematic Violence Monitoring to Reduce Underreporting and to Better Inform Workplace Violence Prevention Among Health Care Workers: Before-and-After Prospective Study., JMIR Public Health Surveill, Vol: 9

BACKGROUND: Monitoring workplace violence (WPV) against health care workers (HCWs) through incident reporting is crucial to drive prevention, but the actual implementation is spotty and experiences underreporting. OBJECTIVE: This study aims to introduce a systematic WPV surveillance in 2 public referral hospitals in Italy and assess underreporting, WPV annual rates, and attributes "before" (2016-2020) and "after" its implementation (November 2021 to 2022). METHODS: During 2016-2020, incident reporting was based on procedures and data collection forms that were neither standardized between hospitals nor specific for aggressions. We planned and implemented a standardized WPV surveillance based on (1) an incident report form for immediate and systematic event notification, adopting international standards for violence definitions; (2) second-level root cause analysis with a dedicated psychologist, assessing violence determinants and impacts and offering psychological counseling; (3) a web-based platform for centralized data collection; and (4) periodic training for workforce coordinators and newly hired workers. We used data from incident reports to estimate underreporting, defined as an observed-to-expected (from literature and the "before" period) WPV ratio less than 1, and the 12-month WPV rates (per 100 HCWs) in the "before" and "after" periods. During the latter period, we separately estimated WPV rates for first and recurrent events. RESULTS: In the "before" period, the yearly observed-to-expected ratios were consistently below 1 and as low as 0.27, suggesting substantial violence underreporting of up to 73%. WPV annual rates declined in 1 hospital (from 1.92 in 2016 to 0.57 in 2020) and rose in the other (from 0.52 to 1.0), with the divergence being attributable to trends in underreporting. Available data were poorly informative to identify at-risk HCW subgroups. In the "after" period, the obs

Journal article

Broccia G, Carter J, Ozsin-Ozler C, De Matteis S, Cocco Pet al., 2023, Epidemiology of Chronic Lymphocytic Leukemia in Sardinia, Italy (1974-2003), EXPERIMENTAL HEMATOLOGY, Vol: 125, Pages: 37-44, ISSN: 0301-472X

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De Matteis S, 2023, Respiratory effects of air pollution: time to stop this deadly trajectory, THORAX, Vol: 78, Pages: 635-636, ISSN: 0040-6376

Journal article

Lecca R, Figorilli M, Casaglia E, Cucca C, Meloni F, Loscerbo R, De Matteis S, Cocco P, Puligheddu Met al., 2023, Gender and Nightshift Work: A Cross Sectional Study on Sleep Quality and Daytime Somnolence, BRAIN SCIENCES, Vol: 13

Journal article

Nafees AA, Muneer MZ, Irfan M, Kadir MM, Semple S, De Matteis S, Burney P, Cullinan Pet al., 2023, Byssinosis and lung health among cotton textile workers: baseline findings of the MultiTex trial in Karachi, Pakistan, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 80, Pages: 129-136, ISSN: 1351-0711

Journal article

Reynolds CJ, Sisodia R, Barber C, Moffatt M, Minelli C, De Matteis S, Cherrie JW, Newman Taylor A, Cullinan Pet al., 2023, What role for asbestos in idiopathic pulmonary fibrosis? Findings from the IPF job exposures case-control study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 80, Pages: 97-103, ISSN: 1351-0711

Journal article

Ratanachina J, Amaral A, De Matteis S, Lawin H, Mortimer K, Obaseki D, Harrabi I, Denguezli M, Wouters E, Janson C, Nielsen R, Gulsvik A, Cherkaski H, Mejza F, Anand M, Elsony A, Ahmed R, Tan W, Loh LC, Rashid A, Studnicka M, Nafees A, Seemungal T, Aquart-Stewart A, Al Ghobain M, Zheng J, Juvekar S, Salvi S, Jogi R, Mannino D, Gislason T, Buist AS, Cullinan P, Burney Pet al., 2023, Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study, European Respiratory Journal, Vol: 60, Pages: 1-16, ISSN: 0903-1936

Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study.We analysed cross-sectional data from 28,823 adults (≥40years) in 34 countries. Eleven occupations were considered and grouped by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, FEV1/FVC and FVC with occupation was assessed, per study site, using multivariable regression. These estimates were then meta-analysed. Sensitivity analyses explored differences between sexes and gross national income (GNI).Overall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20years were more likely to have chronic cough (OR=1.52, 95%CI 1.19-1.94), wheeze (OR=1.37, 95%CI 1.16-1.63), and dyspnoea (OR=1.83, 95%CI 1.53-2.20), but not lower FVC (β=0.02L, 95%CI -0.02L to 0.06L) or lower FEV1/FVC (β=0.04%, 95%CI -0.49% to 0.58%). Some findings differed by sex and GNI. In summary, at a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they associate with more respiratory symptoms. As not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.

Journal article

Broccia G, Carter J, Ozsin-Ozler C, De Matteis S, Cocco Pet al., 2023, Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy., Cancer Control, Vol: 30

BACKGROUND: The epidemiology of myeloid hematologic malignancies in Italy has been poorly investigated. METHODS: We used a validated database of 1974-2003 incident cases of hematologic malignancies among the resident population (all ages) of Sardinia, Italy, to describe the incidence of myeloid malignancies overall (N = 4389 cases) and by subtype. We investigated the time trend of acute myeloid leukemia (N = 1227 cases), chronic myeloid leukemia (N = 613 cases), and myelodysplastic syndrome (N = 1296 cases), and used Bayesian methods to explore their geographic spread, and Poisson regression analysis to estimate their association with environmental and socio-economic factors. RESULTS: The annual standardized (world population) incidence rate (IR) of myeloid malignancies over the study period was 6.5 per 100,000 (95% CI 6.2-6.7). Myelodysplastic syndromes were the most prevalent subgroup (IR = 1.7, 95% CI 1.5-1.8). Incidence of all myeloid malignancies combined increased sharply during the study period with an annual percent change (APC) of 10.06% (95% CI 9.51-10.61), 19.77% for myelodysplastic syndromes (95% CI 19.63-19.91), and 3.18% (95% CI 2.99-3.37) for acute myeloid leukemia. Chronic myeloid leukemia did not show an upward trend. Apart from sporadic excesses in small rural communities and the major urban area, there was no evidence of spatial clustering. The risk of myeloid malignancies increased with increasing prevalence of sheep breeding. CONCLUSIONS: Our results might prompt further research on the local genetic and environmental determinants of myeloid hematologic malignancies.

Journal article

Cherchi R, Cusano R, Orru S, Ferrari PA, Massidda M, Fotia G, De Matteis S, Cocco Pet al., 2023, Next Generation Sequencing for miRNA Detection on the Exhaled Breath Condensate: A Pilot Study, EPIGENETICS INSIGHTS, Vol: 16, ISSN: 2516-8657

Journal article

Visona SD, Crespi E, Belluso E, Capella S, De Matteis S, Filippi F, Lai M, Loscerbo R, Meloni F, Pilia I, Cocco P, Colosio Cet al., 2022, Reconstructing historical exposure to asbestos: the validation of 'educated guesses', OCCUPATIONAL MEDICINE-OXFORD, Vol: 72, Pages: 534-540, ISSN: 0962-7480

Journal article

De Matteis S, Murgia N, 2022, Work-related interstitial lung disease: what is the true burden?, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 26, Pages: 1001-1005, ISSN: 1027-3719

Journal article

De Matteis S, Jarvis D, Darnton L, Consonni D, Kromhout H, Hutchings S, Sadhra SS, Fishwick D, Vermeulen R, Rushton L, Cullinan Pet al., 2022, Lifetime occupational exposures and chronic obstructive pulmonary disease risk in the UK Biobank cohort, Thorax, Vol: 77, Pages: 997-1005, ISSN: 0040-6376

BACKGROUND AND AIM: Occupational exposures are important, preventable causes of COPD. We previously found an increased risk of COPD among six occupations by analysing lifetime job histories and lung function data in the population-based UK Biobank cohort. We aimed to build on these findings and elucidate the underlying potential causal agents to focus preventive strategies. METHODS: We applied the ALOHA+job exposure matrix (JEM) based on the International Standard Classification of Occupations V.1988 codes, where exposure to 12 selected agents was rated as 0 (no exposure), 1 (low) or 2 (high). COPD was spirometrically defined as FEV1/FVC less than the lower limit of normal. We calculated semiquantitative cumulative exposure estimates for each agent by multiplying the duration of exposure and squared intensity. Prevalence ratio (PR) and 95% CI for COPD were estimated using robust Poisson regression adjusted for centre, sex, age, smoking and coexposure to JEM agents. Only associations confirmed among never-smokers and never-asthmatics were considered reliable. RESULTS: Out of 116 375 participants with complete job histories, 94 514 had acceptable/repeatable spirometry and smoking data and were included in the analysis. Pesticide exposure showed increased risk of COPD for ever exposure (PR=1.13, 95% CI 1.01 to 1.28) and high cumulative exposure (PR=1.32, 95% CI 1.12 to 1.56), with positive exposure-response trends (p trend=0.004), which were confirmed among never-smokers (p trend=0.005) and never-asthmatics (p trend=0.001). CONCLUSION: In a large population-based study, occupational exposure to pesticides was associated with risk of COPD. Focused preventive strategies for workers exposed to pesticides can prevent the associated COPD burden.

Journal article

Cocco P, Piro S, Meloni F, Montagna A, Pani M, Pilia I, Padoan M, Miligi L, Magnani C, Gambelunghe A, Muzi G, Ferri GM, Vimercati L, Zanotti R, Scarpa A, Zucca M, Latte GC, Angelucci E, De Matteis S, Puligheddu Met al., 2022, Night shift work and lymphoma: results from an Italian multicentre case-control study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 79, Pages: 452-459, ISSN: 1351-0711

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Cocco P, De Matteis S, 2022, The determinants of the changing speed of spread of COVID-19 across Italy, EPIDEMIOLOGY AND INFECTION, Vol: 150, ISSN: 0950-2688

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De Matteis S, 2022, Occupational causes of chronic obstructive pulmonary disease: an update, CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 22, Pages: 73-79, ISSN: 1528-4050

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Nafees A, De Matteis S, Amaral A, Burney P, Cullinan Pet al., 2022, Impact of using different predictive equations on the prevalence of chronic byssinosis in textile workers in Pakistan, Occupational and Environmental Medicine, Vol: 79, Pages: 242-244, ISSN: 1351-0711

Objective Byssinosis remains a significant problem among textile workers in low/middle-income countries. Here we share our experience of using different prediction equations for assessing ‘chronic’ byssinosis according to the standard WHO classification using measurements of forced expiratory volume in 1 s (FEV1).Methods We enrolled 1910 workers in a randomised controlled trial of an intervention to improve the health of textile workers in Pakistan. We included in analyses the 1724 (90%) men who performed pre-bronchodilator spirometry tests of acceptable quality. We compared four different equations for deriving lung function percentage predicted values among those with symptoms-based byssinosis: the third US National Health and Nutrition Examination Survey (NHANES-III, with ‘North Indian and Pakistani’ conversion factor); the Global Lung Function Initiative (GLI, ‘other or mixed ethnicities’); a recent equation derived from survey of a western Indian population; and one based on an older and smaller survey of Karachi residents.Results 58 men (3.4%) had symptoms-based byssinosis according to WHO criteria. Of these, the proportions with a reduced FEV1 (<80% predicted) identified using NHANES and GLI; Indian and Pakistani reference equations were 40%, 41%, 14% and 12%, respectively. Much of this variation was eliminated when we substituted FEV1/forced vital capacity (FVC) ratio (<lower limit of normality) as a measure of airway obstruction.Conclusion Accurate measures of occupational disease frequency and distribution require approaches that are both standardised and meaningful. We should reconsider the WHO definition of ‘chronic’ byssinosis based on changes in FEV1, and instead use the FEV1/FVC.

Journal article

Broccia G, Carter J, Ozsin-Ozler C, Meloni F, Pilia I, De Matteis S, Cocco Pet al., 2022, Time trend and Bayesian mapping of multiple myeloma incidence in Sardinia, Italy (vol 12, 2736, 2022), SCIENTIFIC REPORTS, Vol: 12, ISSN: 2045-2322

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Veronesi G, De Matteis S, Calori G, Pepe N, Ferrario MMet al., 2022, Long-term exposure to air pollution and COVID-19 incidence: a prospective study of residents in the city of Varese, Northern Italy, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 79, Pages: 192-199, ISSN: 1351-0711

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Broccia G, Carter J, Ozsin-Ozler C, Meloni F, Pilia I, De Matteis S, Cocco Pet al., 2022, Time trend and Bayesian mapping of multiple myeloma incidence in Sardinia, Italy, SCIENTIFIC REPORTS, Vol: 12, ISSN: 2045-2322

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De Matteis S, Forastiere F, Baldacci S, Maio S, Tagliaferro S, Fasola S, Cilluffo G, La Grutta S, Viegi Get al., 2022, Issue 1-"Update on adverse respiratory effects of outdoor air pollution". Part 1): Outdoor air pollution and respiratory diseases: A general update and an Italian perspective, PULMONOLOGY, Vol: 28, Pages: 284-296, ISSN: 2531-0437

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Broccia G, Carter J, Ozsin-Ozler C, Meloni F, De Matteis S, Cocco Pet al., 2022, Incidence of non-Hodgkin's lymphoma among adults in Sardinia, Italy, PLOS ONE, Vol: 17, ISSN: 1932-6203

Journal article

Nafees AA, De Matteis S, Burney P, Cullinan Pet al., 2022, Contemporary prevalence of byssinosis in low- and middle-income countries: a systematic review, Asia-Pacific Journal of Public Health, Vol: 34, Pages: 483-492, ISSN: 1010-5395

We aimed to identify the contemporary prevalence of byssinosis through a systematic review. We used Medline, Web of Science, Embase, and Global Health databases to identify studies published in any language between 2000 and 2019, reporting primary data on byssinosis among adults. We used the Joanna Briggs Institute checklist to estimate the risk of bias in studies and undertook a qualitative, narrative data analysis. The review considered the prevalence of byssinosis, chest tightness, and airflow obstruction in textile workers in low- and middle-income countries (LMICs). We found 26 relevant studies that included 6930 workers across 12 countries. Most of the studies (n = 19) were from Asia, and 7 from African countries. Twenty-five studies were cross-sectional surveys while 1 was a cohort study. The prevalence of byssinosis was reported by 18 studies, and ranged from 8% to 38%, without any clear associations, at the group level, between the prevalence of byssinosis and durations of workers’ exposures. Prevalence of chest tightness ranged between 4% and 58% and that of airflow obstruction between 10% and 30%. We found a strong correlation (r = 0.72) between prevalence of byssinosis and cotton dust levels. Our findings indicate that byssinosis remains a significant, contemporary problem in some parts of the textile sector in LMICs.

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De Matteis S, Cancedda V, Pilia I, Cocco Pet al., 2022, COVID-19 incidence in a cohort of public transport workers, MEDICINA DEL LAVORO, Vol: 113, ISSN: 0025-7818

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Andersen ZJ, Gehring U, De Matteis S, Melen E, Vicedo-Cabrera AM, Katsouyanni K, Yorgancioglu A, Ulrik CS, Medina S, Hansen K, Powell P, Ward B, Hoffmann Bet al., 2021, Clean air for healthy lungs - an urgent call to action: European Respiratory Society position on the launch of the WHO 2021 Air Quality Guidelines, EUROPEAN RESPIRATORY JOURNAL, Vol: 58, ISSN: 0903-1936

Journal article

Lecca R, Puligheddu M, Acar GM, Figorilli M, Congiu P, Gioi G, Loscerbo R, Meloni F, De Matteis S, Cocco Pet al., 2021, Shift rotation scheme, sleepiness and sleep quality in night-shift workers, OCCUPATIONAL MEDICINE-OXFORD, Vol: 71, Pages: 446-452, ISSN: 0962-7480

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Nafees AA, Iqbal AR, Cullinan P, Matteis SD, Burney P, Semple Set al., 2021, Use of low-cost particle counters for cotton dust exposure assessment in textile mills in low- and middle-income countries, Annals of Work Exposures and Health, Vol: 66, ISSN: 2398-7308

OBJECTIVE: There is a lack of consensus on methods for cotton dust measurement in the textile industry, and techniques vary between countries-relying mostly on cumbersome, traditional approaches. We undertook comparisons of standard, gravimetric methods with low-cost optical particle counters for personal and area dust measurements in textile mills in Pakistan. METHODS: We included male textile workers from the weaving sections of seven cotton mills in Karachi. We used the Institute of Occupational Medicine (IOM) sampler with a Casella Apex 2 standard pump and the Purple Air (PA-II-SD) for measuring personal exposures to inhalable airborne particles (n = 31). We used the Dylos DC1700 particle counter, in addition to the two above, for area-level measurements (n = 29). RESULTS: There were no significant correlations between the IOM and PA for personal dust measurements using the original (r = -0.15, P = 0.4) or log-transformed data (r = -0.32, P = 0.07). Similarly, there were no significant correlations when comparing the IOM with either of the particle counters (PA and Dylos) for area dust measurements, using the original (r = -0.07, P = 0.7; r = 0.10, P = 0.6) or log-transformed data (r = -0.09, P = 0.6; r = 0.07, P = 0.7). CONCLUSION: Our findings show a lack of correlation between the gravimetric method and the use of particle counters in both personal and area measurements of cotton dust, precluding their use for measuring occupational exposures to airborne dust in textile mills. There continues to be a need to develop low-cost instruments to help textile industries in low- and middle-income countries to perform cotton dust exposure assessment.

Journal article

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