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@article{Hervera:2019:10.1016/j.tcb.2019.01.006,
author = {Hervera, A and Santos, CX and De, Virgiliis F and Shah, AM and Di, Giovanni S},
doi = {10.1016/j.tcb.2019.01.006},
journal = {Trends in Cell Biology},
pages = {514--530},
title = {Paracrine mechanism of redox signalling for post-mitotic cell and tissue regeneration},
url = {http://dx.doi.org/10.1016/j.tcb.2019.01.006},
volume = {29},
year = {2019}
}

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TY  - JOUR
AB  - Adult postmitotic mammalian cells, including neurons and cardiomyocytes, have a limited capacity to regenerate after injury. Therefore, an understanding of the molecular mechanisms underlying their regenerative ability is critical to advance tissue repair therapies. Recent studies highlight how redox signalling via paracrine cell-to-cell communication may act as a central mechanism coupling tissue injury with regeneration. Post-injury redox paracrine signalling can act by diffusion to nearby cells, through mitochondria or within extracellular vesicles, affecting specific intracellular targets such as kinases, phosphatases, and transcription factors, which in turn trigger a regenerative response. Here, we review redox paracrine signalling mechanisms in postmitotic tissue regeneration and discuss current challenges and future directions.
AU  - Hervera,A
AU  - Santos,CX
AU  - De,Virgiliis F
AU  - Shah,AM
AU  - Di,Giovanni S
DO  - 10.1016/j.tcb.2019.01.006
EP  - 530
PY  - 2019///
SN  - 0962-8924
SP  - 514
TI  - Paracrine mechanism of redox signalling for post-mitotic cell and tissue regeneration
T2  - Trends in Cell Biology
UR  - http://dx.doi.org/10.1016/j.tcb.2019.01.006
UR  - http://hdl.handle.net/10044/1/69004
VL  - 29
ER  -

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