Imperial College London
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ProfessorSimoneDi Giovanni

Faculty of Medicine, Department of Brain Sciences

James W Harnett Chair in Restorative Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 3178s.di-giovanni

 
 
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Location

 

E505Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hart:2013:10.1007/s11934-013-0352-7,
author = {Hart, ML and Neumayer, KMH and Vaegler, M and Daum, L and Amend, B and Sievert, KD and Di, Giovanni S and Kraushaar, U and Guenther, E and Stenzl, A and Aicher, WK},
doi = {10.1007/s11934-013-0352-7},
journal = {Curr Urol Rep},
pages = {476--487},
title = {Cell-based therapy for the deficient urinary sphincter.},
url = {http://dx.doi.org/10.1007/s11934-013-0352-7},
volume = {14},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - When sterile culture techniques of mammalian cells first became state of the art, there was tremendous anticipation that such cells could be eventually applied for therapeutic purposes. The discovery of adult human stem or progenitor cells further motivated scientists to pursue research in cell-based therapies. Although evidence from animal studies suggests that application of cells yields measurable benefits, in urology and many other disciplines, progenitor-cell-based therapies are not yet routinely clinically available. Stress urinary incontinence (SUI) is a condition affecting a large number of patients. The etiology of SUI includes, but is not limited to, degeneration of the urinary sphincter muscle tissue and loss of innervation, as well as anatomical and biomechanical causes. Therefore, different regimens were developed to treat SUI. However, at present, a curative functional treatment is not at hand. A progenitor-cell-based therapy that can tackle the etiology of incontinence, rather than the consequences, is a promising strategy. Therefore, several research teams have intensified their efforts to develop such a therapy for incontinence. Here, we introduce candidate stem and progenitor cells suitable for SUI treatment, show how the functional homogeneity and state of maturity of differentiated cells crucial for proper tissue integration can be assessed electrophysiologically prior to their clinical application, and discuss the trophic potential of adult mesenchymal stromal (or stem) cells in regeneration of neuronal function.
AU  - Hart,ML
AU  - Neumayer,KMH
AU  - Vaegler,M
AU  - Daum,L
AU  - Amend,B
AU  - Sievert,KD
AU  - Di,Giovanni S
AU  - Kraushaar,U
AU  - Guenther,E
AU  - Stenzl,A
AU  - Aicher,WK
DO  - 10.1007/s11934-013-0352-7
EP  - 487
PY  - 2013///
SP  - 476
TI  - Cell-based therapy for the deficient urinary sphincter.
T2  - Curr Urol Rep
UR  - http://dx.doi.org/10.1007/s11934-013-0352-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/23824516
VL  - 14
ER  -
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