Imperial College London
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ProfessorSimoneDi Giovanni

Faculty of Medicine, Department of Brain Sciences

James W Harnett Chair in Restorative Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 3178s.di-giovanni

 
 
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Location

 

E505Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wilson:2016:10.1523/JNEUROSCI.1455-16.2016,
author = {Wilson, C and Munoz-Palma, E and Henriquez, DR and Palmisano, I and Tulio, Nunez M and Di, Giovanni S and Gonzalez-Billault, C},
doi = {10.1523/JNEUROSCI.1455-16.2016},
journal = {Journal of Neuroscience},
pages = {11107--11119},
title = {A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification},
url = {http://dx.doi.org/10.1523/JNEUROSCI.1455-16.2016},
volume = {36},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Physiological levels of ROS support neurite outgrowth and axonal specification, but the mechanisms by which ROS are able to shapeneurons remain unknown. Ca 2, a broad intracellular second messenger, promotes both Rac1 activation and neurite extension. Ca 2releasefromthe endoplasmic reticulum, mediated by boththe IP3R1 and ryanodine receptor (RyR) channels, requires physiological ROSlevels that are mainly sustained by the NADPH oxidase (NOX) complex. In this work, we explore the contribution of the link betweenNOX and RyR-mediated Ca 2 release toward axonal specification of rat hippocampal neurons. Using genetic approaches, we findthatNOX activation promotes both axonal development and Rac1 activationthrough a RyR-mediatedmechanism,whichinturn activatesNOX through Rac1, one of the NOX subunits. Collectively, these data suggest a feedforward mechanism that integrates both NOX activityand RyR-mediated Ca 2 release to support cellular mechanisms involved in axon development.
AU  - Wilson,C
AU  - Munoz-Palma,E
AU  - Henriquez,DR
AU  - Palmisano,I
AU  - Tulio,Nunez M
AU  - Di,Giovanni S
AU  - Gonzalez-Billault,C
DO  - 10.1523/JNEUROSCI.1455-16.2016
EP  - 11119
PY  - 2016///
SN  - 1529-2401
SP  - 11107
TI  - A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification
T2  - Journal of Neuroscience
UR  - http://dx.doi.org/10.1523/JNEUROSCI.1455-16.2016
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391045800017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49776
VL  - 36
ER  -
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