Imperial College London
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ProfessorSimoneDi Giovanni

Faculty of Medicine, Department of Brain Sciences

James W Harnett Chair in Restorative Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 3178s.di-giovanni

 
 
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Location

 

E505Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hervera:2018:10.1038/s41556-018-0039-x,
author = {Hervera, A and De, Virgiliis F and Palmisano, I and Zhou, L and Tantardini, E and Kong, G and Hutson, T and Danzi, MC and Perry, RB-T and Santos, CXC and Kapustin, AN and Fleck, RA and Antonio, Del Rio J and Carroll, T and Lemmon, V and Bixby, JL and Shah, AM and Fainzilber, M and Di, Giovanni S},
doi = {10.1038/s41556-018-0039-x},
journal = {Nature Cell Biology},
pages = {307--319},
title = {Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons},
url = {http://dx.doi.org/10.1038/s41556-018-0039-x},
volume = {20},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by the inflammatory response after injury. Here we show that ROS, which promote axonal dieback and degeneration after injury, are also required for axonal regeneration and functional recovery after spinal injury. We find that ROS production in the injured sciatic nerve and dorsal root ganglia requires CX3CR1-dependent recruitment of inflammatory cells. Next, exosomes containing functional NADPH oxidase 2 complexes are released from macrophages and incorporated into injured axons via endocytosis. Once in axonal endosomes, active NOX2 is retrogradely transported to the cell body through an importin-β1–dynein-dependent mechanism. Endosomal NOX2 oxidizes PTEN, which leads to its inactivation, thus stimulating PI3K–phosporylated (p-)Akt signalling and regenerative outgrowth. Challenging the view that ROS are exclusively involved in nerve degeneration, we propose a previously unrecognized role of ROS in mammalian axonal regeneration through a NOX2–PI3K–p-Akt signalling pathway.
AU  - Hervera,A
AU  - De,Virgiliis F
AU  - Palmisano,I
AU  - Zhou,L
AU  - Tantardini,E
AU  - Kong,G
AU  - Hutson,T
AU  - Danzi,MC
AU  - Perry,RB-T
AU  - Santos,CXC
AU  - Kapustin,AN
AU  - Fleck,RA
AU  - Antonio,Del Rio J
AU  - Carroll,T
AU  - Lemmon,V
AU  - Bixby,JL
AU  - Shah,AM
AU  - Fainzilber,M
AU  - Di,Giovanni S
DO  - 10.1038/s41556-018-0039-x
EP  - 319
PY  - 2018///
SN  - 1465-7392
SP  - 307
TI  - Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons
T2  - Nature Cell Biology
UR  - http://dx.doi.org/10.1038/s41556-018-0039-x
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426059400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 20
ER  -
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