Publications
11 results found
Footitt J, Mallia P, Durham AL, et al., 2016, Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD., Chest, Vol: 149, Pages: 62-73, ISSN: 1931-3543
BACKGROUND: Respiratory virus infections are commonly associated with COPD exacerbations, but little is known about the mechanisms linking virus infection to exacerbations. Pathogenic mechanisms in stable COPD include oxidative and nitrosative stress and reduced activity of histone deacetylase-2 (HDAC2), but their roles in COPD exacerbations is unknown. We investigated oxidative and nitrosative stress (O&NS) and HDAC2 in COPD exacerbations using experimental rhinovirus infection. METHODS: Nine subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II), 10 smokers, and 11 nonsmokers were successfully infected with rhinovirus. Markers of O&NS-associated cellular damage, and inflammatory mediators and proteases were measured in sputum, and HDAC2 activity was measured in sputum and bronchoalveolar macrophages. In an in vitro model, monocyte-derived THP-1 cells were infected with rhinovirus and nitrosylation and activity of HDAC2 was measured. RESULTS: Rhinovirus infection induced significant increases in airways inflammation and markers of O&NS in subjects with COPD. O&NS markers correlated with virus load and inflammatory markers. Macrophage HDAC2 activity was reduced during exacerbation and correlated inversely with virus load, inflammatory markers, and nitrosative stress. Sputum macrophage HDAC2 activity pre-infection was inversely associated with sputum virus load and inflammatory markers during exacerbation. Rhinovirus infection of monocytes induced nitrosylation of HDAC2 and reduced HDAC2 activity; inhibition of O&NS inhibited rhinovirus-induced inflammatory cytokines. CONCLUSIONS: O&NS, airways inflammation, and impaired HDAC2 may be important mechanisms of virus-induced COPD exacerbations. Therapies targeting these mechanisms offer potential new treatments for COPD exacerbations.
Durham AL, Footitt J, Essilfie-Quaye S, et al., 2015, LSC Abstract - Rhinovirus infection induces NRF2 in monocytes but not in epithelial cells, via distinct intracellular pathways, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Footitt J, Mallia P, Durham A, et al., 2013, HDAC ACTIVITY IN MACROPHAGES IN EXPERIMENTAL RHINOVIRUS INFECTION IN COPD, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A58-A59, ISSN: 0040-6376
Haque R, Hakim A, Moodley T, et al., 2013, Inhaled long-acting β<sub>2</sub> agonists enhance glucocorticoid receptor nuclear translocation and efficacy in sputum macrophages in COPD, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 1166-1173, ISSN: 0091-6749
- Author Web Link
- Open Access Link
- Cite
- Citations: 38
Essilfie-Quaye S, Ito K, Ito M, et al., 2011, Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients, RESPIRATORY MEDICINE, Vol: 105, Pages: 1784-1789, ISSN: 0954-6111
- Author Web Link
- Cite
- Citations: 6
Durham A, Essilfie-Quaye S, Ngjelo A, et al., 2010, Female Sex Hormones Modulate Inflammatory Mediator Expression From Bronchial Epithelial Cells, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, ISSN: 1073-449X
Essilfie-Quaye S, Barnes PJ, Ito K, 2009, Glucocorticoid Receptor Acetylation in Patients with COPD., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Maneechotesuwan K, Essilfie-Quaye S, Kharitonov SA, et al., 2007, Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils, CHEST, Vol: 132, Pages: 98-105, ISSN: 0012-3692
- Author Web Link
- Cite
- Citations: 49
Ito K, Yamamura S, Essilfie-Quaye S, et al., 2006, Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappa B suppression, Journal of Experimental Medicine, Vol: 203, Pages: 7-13, ISSN: 1540-9538
Maneechotesuwan K, Essilfie-Quaye S, Meah S, et al., 2005, Formoterol attenuates neutrophilic airway inflammation in asthma, CHEST, Vol: 128, Pages: 1936-1942, ISSN: 0012-3692
- Author Web Link
- Cite
- Citations: 58
Basoglu OK, Pelleg A, Essilfie-Quaye S, et al., 2005, Effects of aerosolized adenosine 5′-triphosphate vs adenosine 5′-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma, CHEST, Vol: 128, Pages: 1905-1909, ISSN: 0012-3692
- Author Web Link
- Cite
- Citations: 72
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.