Summary
The main focus of the research group is in translational research in gynaecological cancers. In particular biomarker discovery and development (specifically immunological markers) in ovarian and endometrial cancers. The biomarkers are now in the process of being tested for diagnosis and surgical prognosis. The concept of predicting surgical outcome in ovarian cancer is a step in developing personalised medicine and providing patients with best care possible.
Recent advances in oncolgy have improved survival in patients with cancer but research into surgery may have additional benefits for the patient. Clinical research into optimal treatment of cervival preinvasive lesions has been a focus. We have shown that clear margins of resection has a significant effect on reducing risk of recurrence from preinvasive disease.
Publications
Journals
Natoli M, Bonito N, Robinson JD, et al., 2020, Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade., Cancer Immunol Immunother
Tzafetas M, Mitra A, Paraskevaidi M, et al., The intelligent-Knife (i-Knife) and its intraoperative diagnostic advantage for the treatment of cervical disease., Proceedings of the National Academy of Sciences of Usa, ISSN:0027-8424
Jones BP, Vali S, Saso S, et al., 2020, Endometrial autotransplantation in rabbits: Potential for fertility restoration in severe Asherman's syndrome., Eur J Obstet Gynecol Reprod Biol, Vol:248, Pages:14-23
L'Heveder A, Jones BP, Saso S, et al., 2019, Conservative management of uterine adenosarcoma: lessons learned from 20 years of follow-up, Archives of Gynecology and Obstetrics, Vol:300, ISSN:0932-0067, Pages:1383-1389
Crosbie EJ, Ryan NAJ, Arends MJ, et al., 2019, The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome, Genetics in Medicine, Vol:21, ISSN:1098-3600, Pages:2390-2400