Summary
The main focus of the research group is in translational research in gynaecological cancers. In particular biomarker discovery and development (specifically immunological markers) in ovarian and endometrial cancers. The biomarkers are now in the process of being tested for diagnosis and surgical prognosis. The concept of predicting surgical outcome in ovarian cancer is a step in developing personalised medicine and providing patients with best care possible.
Recent advances in oncolgy have improved survival in patients with cancer but research into surgery may have additional benefits for the patient. Clinical research into optimal treatment of cervival preinvasive lesions has been a focus. We have shown that clear margins of resection has a significant effect on reducing risk of recurrence from preinvasive disease.
Publications
Journals
Phelps DL, Balog J, Gildea LF, et al., The Surgical Intelligent Knife Distinguishes Normal, Borderline and Malignant Gynaecological Tissues using Rapid Evaporative Ionisation Mass Spectrometry (REIMS), British Journal of Cancer, ISSN:0007-0920
Curry E, Zeller C, Masrour N, et al., 2018, Genes Predisposed to DNA Hypermethylation during Acquired Resistance to Chemotherapy Are Identified in Ovarian Tumors by Bivalent Chromatin Domains at Initial Diagnosis, Cancer Research, Vol:78, ISSN:0008-5472, Pages:1383-1391
Flower KJ, Ghaem-Maghami S, Brown R, 2018, Is there a Role for Epigenetic Enhancement of Immunomodulatory Approaches to Cancer Treatment?, Current Cancer Drug Targets, Vol:18, ISSN:1568-0096, Pages:5-15
Chatterjee J, Dai W, Abd Aziz NH, et al., 2017, Clinical Use of Programmed Cell Death-1 and Its Ligand Expression as Discriminatory and Predictive Markers in Ovarian Cancer, Clinical Cancer Research, Vol:23, ISSN:1078-0432, Pages:3453-3460
Conference
Tzafetas M, Mitra A, Kalliala I, et al., 2018, iKinfe - improving surgical outcomes in pre-invasive and invasive cervical disease, WILEY, Pages:17-17, ISSN:1470-0328