Imperial College London

Prof Steve Matthews

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Chemical and Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 5315s.j.matthews Website

 
 
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Location

 

Room 602Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

190 results found

Polo LM, Grundy G, Rulten S, Xu Y, Matthews S, Caldecot K, Oliver A, Pearl Let al., 2015, New structural insights into PARP3 function, 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Publisher: WILEY-BLACKWELL, Pages: 397-397, ISSN: 1742-464X

CONFERENCE PAPER

Wong CT, Xu Y, Gupta A, Garnett JA, Matthews SJ, Hare SAet al., 2015, Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Berry AA, Yang Y, Pakharukova N, Garnett JA, Lee W-C, Cota E, Marchant J, Roy S, Tuittila M, Liu B, Inman KG, Ruiz-Perez F, Mandomando I, Nataro JP, Zavialov AV, Matthews Set al., 2014, Structural Insight into Host Recognition by Aggregative Adherence Fimbriae of Enteroaggregative Escherichia coli, PLOS PATHOGENS, Vol: 10, ISSN: 1553-7366

JOURNAL ARTICLE

Lambert SM, Langley DR, Garnett JA, Angell R, Hedgethorne K, Meanwell NA, Matthews SJet al., 2014, The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors, PROTEIN SCIENCE, Vol: 23, Pages: 723-734, ISSN: 0961-8368

JOURNAL ARTICLE

Lin J, Oh S-H, Jones R, Garnett JA, Salgado PS, Rusnakova S, Matthews SJ, Hoyer LL, Cota Eet al., 2014, The Peptide-binding Cavity Is Essential for Als3-mediated Adhesion of Candida albicans to Human Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 289, Pages: 18401-18412, ISSN: 0021-9258

JOURNAL ARTICLE

Liu B, Shadrin A, Sheppard C, Mekler V, Xu Y, Severinov K, Matthews S, Wigneshweraraj Set al., 2014, A bacteriophage transcription regulator inhibits bacterial transcription initiation by Sigma-factor displacement, NUCLEIC ACIDS RESEARCH, Vol: 42, Pages: 4294-4305, ISSN: 0305-1048

JOURNAL ARTICLE

Liu B, Shadrin A, Sheppard C, Mekler V, Xu Y, Severinov K, Matthews S, Wigneshweraraj Set al., 2014, The sabotage of the bacterial transcription machinery by a small bacteriophage protein., Bacteriophage, Vol: 4, ISSN: 2159-7073

Many bacteriophages produce small proteins that specifically interfere with the bacterial host transcription machinery and thus contribute to the acquisition of the bacterial cell by the bacteriophage. We recently described how a small protein, called P7, produced by the Xp10 bacteriophage inhibits bacterial transcription initiation by causing the dissociation of the promoter specificity sigma factor subunit from the host RNA polymerase holoenzyme. In this addendum to the original publication, we present the highlights of that research.

JOURNAL ARTICLE

Matsuo E, Leon E, Matthews SJ, Roy Pet al., 2014, Structure based modification of Bluetongue virus helicase protein VP6 to produce a viable VP6-truncated BTV, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 451, Pages: 603-608, ISSN: 0006-291X

JOURNAL ARTICLE

Mousnier A, Schroeder GN, Stoneham CA, So EC, Garnett JA, Yu L, Matthews SJ, Choudhary JS, Hartland EL, Frankel Get al., 2014, A New Method To Determine In Vivo Interactomes Reveals Binding of the Legionella pneumophila Effector PieE to Multiple Rab GTPases, MBIO, Vol: 5, ISSN: 2150-7511

JOURNAL ARTICLE

Xu Y, Plechanovova A, Simpson P, Marchant J, Leidecker O, Kraatz S, Hay RT, Matthews SJet al., 2014, Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4, NATURE COMMUNICATIONS, Vol: 5, ISSN: 2041-1723

JOURNAL ARTICLE

Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel Get al., 2014, The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation, NATURE COMMUNICATIONS, Vol: 5, ISSN: 2041-1723

JOURNAL ARTICLE

Cehovin A, Simpson PJ, McDowell MA, Brown DR, Noschese R, Pallett M, Brady J, Baldwin GS, Lea SM, Matthews SJ, Pelicic Vet al., 2013, Specific DNA recognition mediated by a type IV pilin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 3065-3070, ISSN: 0027-8424

JOURNAL ARTICLE

Leen EN, Kwok KYR, Birtley JR, Simpson PJ, Subba-Reddy CV, Chaudhry Y, Sosnovtsev SV, Green KY, Prater SN, Tong M, Young JC, Chung LMW, Marchant J, Roberts LO, Kao CC, Matthews S, Goodfellow IG, Curry Set al., 2013, Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins, JOURNAL OF VIROLOGY, Vol: 87, Pages: 5318-5330, ISSN: 0022-538X

JOURNAL ARTICLE

Lu Z, Bergeron JRC, Atkinson RA, Schaller T, Veselkov DA, Oregioni A, Yang Y, Matthews SJ, Malim MH, Sanderson MRet al., 2013, Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction, OPEN BIOLOGY, Vol: 3, ISSN: 2046-2441

JOURNAL ARTICLE

Matthews S, Heise H, 2013, Modern NMR Methodology Preface, Publisher: SPRINGER-VERLAG BERLIN

BOOK

Muniz-Feliciano L, Van Grol J, Portillo J-AC, Liew L, Liu B, Carlin CR, Carruthers VB, Matthews S, Subauste CSet al., 2013, Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite, PLOS PATHOGENS, Vol: 9, ISSN: 1553-7366

JOURNAL ARTICLE

Sheppard C, James E, Barton G, Matthews S, Severinov K, Wigneshweraraj Set al., 2013, A non-bacterial transcription factor inhibits bacterial transcription by a multipronged mechanism, RNA BIOLOGY, Vol: 10, Pages: 495-501, ISSN: 1547-6286

JOURNAL ARTICLE

Tabib-Salazar A, Liu B, Doughty P, Lewis RA, Ghosh S, Parsy M-L, Simpson PJ, O'Dwyer K, Matthews SJ, Paget MSet al., 2013, The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase, NUCLEIC ACIDS RESEARCH, Vol: 41, Pages: 5679-5691, ISSN: 0305-1048

JOURNAL ARTICLE

Xu Y, Matthews S, 2013, TROSY NMR Spectroscopy of Large Soluble Proteins, MODERN NMR METHODOLOGY, Vol: 335, Pages: 97-119, ISSN: 0340-1022

JOURNAL ARTICLE

Xu Y, Matthews S, 2013, MAP-XSII: an improved program for the automatic assignment of methyl resonances in large proteins, JOURNAL OF BIOMOLECULAR NMR, Vol: 55, Pages: 179-187, ISSN: 0925-2738

JOURNAL ARTICLE

Xu Y, Matthews S, 2013, TROSY NMR spectroscopy of large soluble proteins, Topics in Current Chemistry, Vol: 335, Pages: 97-119, ISSN: 0340-1022

Solution nuclear magnetic resonance spectroscopy is usually only used to study proteins with molecular weight not exceeding about 50 kDa. This size limit has been lifted significantly in recent years, thanks to the development of labelling methods and the application of transverse-relaxation optimized spectroscopy (TROSY). In particular, methyl-specific labelling and methyl-TROSY have been shown to be effective for supramolecular systems as large as about 1 MDa. In this chapter we review the available methods for labelling different kinds of methyl groups and the assignment strategies in very large protein systems. Several proteins are selected as examples to show how NMR helps to reveal the details of structure, interaction and dynamics of these proteins. © Springer-Verlag Berlin Heidelberg 2011.

JOURNAL ARTICLE

Bleijlevens B, Shivarattan T, van den Boom KS, de Haan A, van der Zwan G, Simpson PJ, Matthews SJet al., 2012, Changes in Protein Dynamics of the DNA Repair Dioxygenase AlkB upon Binding of Fe2+ and 2-Oxoglutarate, BIOCHEMISTRY, Vol: 51, Pages: 3334-3341, ISSN: 0006-2960

JOURNAL ARTICLE

Cowper B, Matthews S, Tomley F, 2012, The molecular basis for the distinct host and tissue tropisms of coccidian parasites, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 186, Pages: 1-10, ISSN: 0166-6851

JOURNAL ARTICLE

Garnett JA, Martinez-Santos VI, Saldana Z, Pape T, Hawthorne W, Chan J, Simpson PJ, Cota E, Puente JL, Giron JA, Matthews Set al., 2012, Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 3950-3955, ISSN: 0027-8424

JOURNAL ARTICLE

Garnett JA, Matthews S, 2012, Interactions in Bacterial Biofilm Development: A Structural Perspective, CURRENT PROTEIN & PEPTIDE SCIENCE, Vol: 13, Pages: 739-755, ISSN: 1389-2037

JOURNAL ARTICLE

Garnett JA, Simpson PJ, Taylor J, Benjamin SV, Tagliaferri C, Cota E, Chen Y-YM, Wu H, Matthews Set al., 2012, Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 417, Pages: 421-426, ISSN: 0006-291X

JOURNAL ARTICLE

Hughes S, Elustondo F, Di Fonzo A, Leroux FG, Wong AC, Snijders AP, Matthews SJ, Cherepanov Pet al., 2012, Crystal structure of human CDC7 kinase in complex with its activator DBF4, NATURE STRUCTURAL & MOLECULAR BIOLOGY, Vol: 19, Pages: 1101-+, ISSN: 1545-9993

JOURNAL ARTICLE

James E, Liu M, Sheppard C, Mekler V, Camara B, Liu B, Simpson P, Cota E, Severinov K, Matthews S, Wigneshweraraj Set al., 2012, Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2, MOLECULAR CELL, Vol: 47, Pages: 755-766, ISSN: 1097-2765

JOURNAL ARTICLE

Liu B, Garnett JA, Lee W-C, Lin J, Salgado P, Taylor J, Xu Y, Lambert S, Cota E, Matthews Set al., 2012, Promoting crystallisation of the Salmonella enteritidis fimbriae 14 pilin SefD using deuterium oxide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 421, Pages: 208-213, ISSN: 0006-291X

JOURNAL ARTICLE

Marchant J, Cowper B, Liu Y, Lai L, Pinzan C, Marq JB, Friedrich N, Sawmynaden K, Liew L, Chai W, Childs RA, Saouros S, Simpson P, Roque Barreira MC, Feizi T, Soldati-Favre D, Matthews Set al., 2012, Galactose Recognition by the Apicomplexan Parasite Toxoplasma gondii, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 287, Pages: 16720-16733, ISSN: 0021-9258

JOURNAL ARTICLE

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