Imperial College London

Prof Steve Matthews

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Chemical and Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 5315s.j.matthews Website

 
 
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Location

 

Room 602Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

190 results found

Saouros S, Edwards-Jones B, Reiss M, Sawmynaden K, Cota E, Simpson P, Dowse TJ, Jakle U, Ramboarina S, Shivarattan T, Matthews S, Soldati-Favre Det al., 2005, A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 38583-38591, ISSN: 0021-9258

JOURNAL ARTICLE

Shivarattan T, Chen HA, Simpson P, Sedgwick B, Matthews Set al., 2005, Resonance assignments of Escherichia coli AlkB: a key 2-oxoglutarate and Fe(II) dependent dioxygenase of the adaptive DNA-repair response, JOURNAL OF BIOMOLECULAR NMR, Vol: 33, Pages: 138-138, ISSN: 0925-2738

JOURNAL ARTICLE

Szendroi A, Simpson P, Ghuman J, Matthews S, Curry Set al., 2005, Structural and functional analyses of eukaryotic initiation factor 4B (eIF4B) to study its role in cap-independent translation initiation of picornaviral IRESes, FEBS JOURNAL, Vol: 272, Pages: 392-393, ISSN: 1742-464X

JOURNAL ARTICLE

Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RAG, Nowicki B, Le Bouguenec C, Lea SM, Matthews Set al., 2004, An atomic resolution model for assembly, architecture, and function of the Dr adhesins, MOLECULAR CELL, Vol: 15, Pages: 647-657, ISSN: 1097-2765

JOURNAL ARTICLE

Anderson KL, Cota E, Simpson P, Chen HA, du Merle L, Le Bouguenec C, Matthews Set al., 2004, Letter to the Editor: Complete resonance assignments of a 'donor-strand complemented' AfaE: The afimbrial adhesin from Diffusely Adherent E-coli, JOURNAL OF BIOMOLECULAR NMR, Vol: 29, Pages: 409-410, ISSN: 0925-2738

JOURNAL ARTICLE

Cota E, Chen HA, Anderson KL, Simpson P, du Merle L, Bernier-Febreau C, Piaatek R, Zalewska B, Nowicki B, Kur J, Le Bouguenec C, Matthews Set al., 2004, Letter to the Editor: Complete resonance assignments of the 'donor-strand complemented' AfaD: The afimbrial invasin from Diffusely Adherent E-coli, JOURNAL OF BIOMOLECULAR NMR, Vol: 29, Pages: 411-412, ISSN: 0925-2738

JOURNAL ARTICLE

Dreveny I, Pye VE, Beuron F, Briggs LC, Isaacson RL, Matthews SJ, McKeown C, Yuan X, Zhang X, Freemont PSet al., 2004, P97 and close encounters of every kind: a brief review, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 32, Pages: 715-720, ISSN: 0300-5127

JOURNAL ARTICLE

Fleming K, Matthews S, 2004, Media for studies of partially aligned states., Methods Mol Biol, Vol: 278, Pages: 79-88, ISSN: 1064-3745

Measurement of residual dipolar couplings for proteins in nuclear magnetic resonance (NMR) requires a degree of molecular alignment. This may be achieved through the use of liquid crystals or compressed hydrated gels. Several media have been described in the literature, and this chapter describes five of the most commonly used systems. For two of these systems, bicelles and filamentous bacteriophage, the media can be purchased in a form ready for experiments. The remainder must be made by the investigator, yet they are generally straightforward to synthesize in the laboratory. Poly(ethylene glycol)/alcohol mixtures and Helfrich phases are made by simply mixing the ingredients in the correct manner, and strained gels use techniques familiar to all molecular biologists.

JOURNAL ARTICLE

Matthews S, 2004, Perdeuteration/site-specific protonation approaches for high-molecular-weight proteins., Methods Mol Biol, Vol: 278, Pages: 35-45, ISSN: 1064-3745

Among the factors that limit the application of nuclear magnetic resonance (NMR) to biological macromolecules are increasing resonance overlap and fast transverse relaxation. Multidimensional NMR combined with 13C and 15N labeling has alleviated these problems temporarily; however, they resurface at molecular weight (mol wt) in excess of 30 kDa. Combined perdeuteration/site-specific protonation together with segmental labeling, transverse relaxation-optimized spectroscopy (TROSY), and residual dipolar couplings have all helped to dramatically extend the mol wt limit. This article describes some of the practical aspects of the combined perdeuteration/site-specific protonation approach, which has proved so useful in the global fold determination of large proteins.

JOURNAL ARTICLE

Matthews S, 2004, NMR of proteins and nucleic acids, RSc Special Periodical Reports, Editors: webb, Pages: 326-356

BOOK CHAPTER

Pettigrew D, Anderson KL, Billington J, Cota E, Simpson P, Urvil P, Rabuzin F, Roversi P, Nowicki B, du Merle L, Le Bouguenec C, Matthews S, Lea SMet al., 2004, High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 46851-46857, ISSN: 0021-9258

JOURNAL ARTICLE

Pettigrew D, Roversi P, Bhella D, Billington J, Anderson KL, Cota E, Nowicki B, Le Bouguenec C, Medof E, Smith RAG, Barlow PN, Matthews S, Lea SMet al., 2004, Structural studies of CD55 interactions with pathogen-derived ligands, MOLECULAR IMMUNOLOGY, Vol: 41, Pages: 293-293, ISSN: 0161-5890

JOURNAL ARTICLE

Prasannan S, Simpson P, Wilson RK, Crepin VF, Frankel G, Matthews Set al., 2004, Letter to the Editor: H-1, C-13, and N-15 resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic E-coli (EPEC), JOURNAL OF BIOMOLECULAR NMR, Vol: 30, Pages: 387-388, ISSN: 0925-2738

JOURNAL ARTICLE

Prasannan S, Simpson P, Wilson RK, Crepin VF, Frankel G, Matthews Set al., 2004, (1)H, (13)C, and (15)N resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic E. coli (EPEC)., J Biomol NMR, Vol: 30, Pages: 387-388, ISSN: 0925-2738

JOURNAL ARTICLE

Ramboarina S, Fernandes P, Simpson P, Frankel G, Donnenberg M, Matthews Set al., 2004, Letter to the Editor: Complete resonance assignments of bundlin (BfpA) from the bundle-forming pilus of enteropathogenic Escherichia coli, JOURNAL OF BIOMOLECULAR NMR, Vol: 29, Pages: 427-428, ISSN: 0925-2738

JOURNAL ARTICLE

Ramboarina S, Fernandes P, Simpson P, Frankel G, Donnenberg M, Matthews Set al., 2004, Complete resonance assignments of bundlin (BfpA) from the bundle-forming pilus of enteropathogenic Escherichia coli., J Biomol NMR, Vol: 29, Pages: 427-428, ISSN: 0925-2738

JOURNAL ARTICLE

Simpson PJ, Monie TP, Szendroi A, Davydova N, Tyzack JK, Conte MR, Read CM, Cary PD, Svergun DI, Konarev PV, Curry S, Matthews Set al., 2004, Structure and RNA interactions of the N-terminal RRM domains of PTB, STRUCTURE, Vol: 12, Pages: 1631-1643, ISSN: 0969-2126

JOURNAL ARTICLE

Yuan XM, Simpson P, Kondo H, Mckeown C, Dreveny I, Zhang XD, Freemont PS, Matthews Set al., 2004, Letter to the Editor: Complete backbone resonance assignments of p47: The 41kDa adaptor protein of the AAA ATPase p97, JOURNAL OF BIOMOLECULAR NMR, Vol: 28, Pages: 309-310, ISSN: 0925-2738

JOURNAL ARTICLE

Yuan XM, Simpson P, Mckeown C, Kondo H, Uchiyama K, Wallis R, Dreveny I, Keetch C, Zhang XD, Robinson C, Freemont P, Matthews Set al., 2004, Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97, EMBO JOURNAL, Vol: 23, Pages: 1463-1473, ISSN: 0261-4189

JOURNAL ARTICLE

Fleming K, Ghuman J, Yuan XM, Simpson P, Szendroi A, Matthews S, Curry Set al., 2003, Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B, BIOCHEMISTRY, Vol: 42, Pages: 8966-8975, ISSN: 0006-2960

JOURNAL ARTICLE

Mathieu R, Lim J, Simpson P, Prasannan S, Fairweather N, Matthews Set al., 2003, Resonance assignment and topology of a clostridial repetitive oligopeptide (CROP) region of toxin A from Clostridium difficile, JOURNAL OF BIOMOLECULAR NMR, Vol: 25, Pages: 83-84, ISSN: 0925-2738

JOURNAL ARTICLE

Matthews S, 2003, NMR of proteins and nucleic acids, RSc Special Periodical Reports, Editors: webb, Pages: 309-334

BOOK CHAPTER

Brauer ABE, Domingo GJ, Cooke RM, Matthews SJ, Leatherbarrow RJet al., 2002, A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein, BIOCHEMISTRY, Vol: 41, Pages: 10608-10615, ISSN: 0006-2960

JOURNAL ARTICLE

Brauer ABE, Kelly G, Matthews SJ, Leatherbarrow RJet al., 2002, The H-1-NMR solution structure of the antitryptic core peptide of Bowman-Birk inhibitor proteins: A minimal 'canonical loop', JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Vol: 20, Pages: 59-70, ISSN: 0739-1102

JOURNAL ARTICLE

Matthews S, 2002, NMR of proteins and nucleic acids, RSc Special Periodical Reports, Editors: Webb, Pages: 312-332

BOOK CHAPTER

Reece S, Simmons CP, Fitzhenry RJ, Batchelor M, Hale C, Matthews S, Phillips AD, Dougan G, Frankel Get al., 2002, Mutagenesis of conserved tryptophan residues within the receptor-binding domain of intimin: influence on binding activity and virulence, MICROBIOLOGY-SGM, Vol: 148, Pages: 657-665, ISSN: 1350-0872

JOURNAL ARTICLE

Reece S, Simmons CP, Fitzhenry RJ, Ghaem-Maghami M, Mundy R, Hale C, Matthews S, Dougan G, Phillips AD, Frankel Get al., 2002, Tyrosine residues at the immunoglobulin-C-type lectin inter-domain boundary of intimin are not involved in Tir-binding but implicated in colonisation of the host, MICROBES AND INFECTION, Vol: 4, Pages: 1389-1399, ISSN: 1286-4579

JOURNAL ARTICLE

Simpson PJ, Davydova N, Curry S, Matthews Set al., 2002, Letter to the Editor: Resonance assignment and topology of the H-2, C-13, N-15 labelled 29 kDa N-terminal fragment of the polypyrimidine tract binding protein (PTB), JOURNAL OF BIOMOLECULAR NMR, Vol: 24, Pages: 79-80, ISSN: 0925-2738

JOURNAL ARTICLE

Simpson PJ, Davydova N, Curry S, Matthews Set al., 2002, Resonance assignment and topology of the 2H, 13C, 15N labelled 29 kDa N-terminal fragment of the polypyrimidine tract binding protein (PTB)., J Biomol NMR, Vol: 24, Pages: 79-80, ISSN: 0925-2738

JOURNAL ARTICLE

Yuan XM, Davydova N, Conte MR, Curry S, Matthews Set al., 2002, Chemical shift mapping of RNA interactions with the polypyrimidine tract binding protein, NUCLEIC ACIDS RESEARCH, Vol: 30, Pages: 456-462, ISSN: 0305-1048

JOURNAL ARTICLE

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