Imperial College London

Prof Steve Matthews

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Chemical and Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 5315s.j.matthews Website

 
 
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Location

 

602Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

203 results found

Petoukhov MV, Monie TP, Allain FHT, Matthews S, Curry S, Svergun DIet al., 2006, Conformation of polypyrimidine tract binding protein in solution, STRUCTURE, Vol: 14, Pages: 1021-1027, ISSN: 0969-2126

JOURNAL ARTICLE

Rideau AP, Gooding C, Simpson PJ, Monie TP, Lorenz M, Huettelmaier S, Singer RH, Matthews S, Curry S, Smith CWJet al., 2006, A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain, NATURE STRUCTURAL & MOLECULAR BIOLOGY, Vol: 13, Pages: 839-848, ISSN: 1545-9985

JOURNAL ARTICLE

Chen HA, Simpson P, Huyton T, Roper D, Matthews Set al., 2005, Solution structure and interactions of the Escherichia coli cell division activator protein CedA, BIOCHEMISTRY, Vol: 44, Pages: 6738-6744, ISSN: 0006-2960

JOURNAL ARTICLE

Crepin VF, Prasannan S, Shaw RK, Wilson RK, Creasey E, Abe CM, Knutton S, Frankel G, Matthews Set al., 2005, Structural and functional studies of the enteropathogenic Escherichia coli type III needle complex protein EscJ, MOLECULAR MICROBIOLOGY, Vol: 55, Pages: 1658-1670, ISSN: 0950-382X

JOURNAL ARTICLE

Das M, Hart-Van Tassell A, Urvil PT, Lea S, Pettigrew D, Anderson KL, Samet A, Kur J, Matthews S, Nowicki S, Popov V, Goluszko P, Nowicki BJet al., 2005, Hydrophilic domain II of Escherichia coli Dr fimbriae facilitates cell invasion, INFECTION AND IMMUNITY, Vol: 73, Pages: 6119-6126, ISSN: 0019-9567

JOURNAL ARTICLE

Jaulent AM, Brauer ABE, Matthews SJ, Leatherbarrow RJet al., 2005, Solution structure of a novel C-2-symmetrical bifunctional bicyclic inhibitor based on SFTI-1, JOURNAL OF BIOMOLECULAR NMR, Vol: 33, Pages: 57-62, ISSN: 0925-2738

JOURNAL ARTICLE

Matthews S, 2005, NMR of proteins and nucleic acids, RSc Special Periodical Reports, Editors: Webb, Pages: 355-390

BOOK CHAPTER

Monie TP, Hernandez H, Robinson CV, Simpson P, Matthews S, Curry Set al., 2005, The polypyrimidine tract binding protein is a monomer, RNA-A PUBLICATION OF THE RNA SOCIETY, Vol: 11, Pages: 1803-1808, ISSN: 1355-8382

JOURNAL ARTICLE

Oliver AW, Jones SA, Roe SM, Matthews S, Goodwin GH, Pearl LHet al., 2005, Crystal structure of the proximal BAH domain of the polybromo protein, BIOCHEMICAL JOURNAL, Vol: 389, Pages: 657-664, ISSN: 0264-6021

JOURNAL ARTICLE

Ramboarina S, Fernandes PJ, Daniell S, Islam S, Simpson P, Frankel G, Booy F, Donnenberg MS, Matthews Set al., 2005, Structure of the bundle-forming pilus from enteropathogenic Escherichia coli, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 40252-40260, ISSN: 0021-9258

JOURNAL ARTICLE

Saouros S, Chen HA, Simpson P, Cota E, Edwards-Jones B, Soldati-Favre D, Matthews Set al., 2005, Letter to the Editor: Complete resonance assignments of the C-terminal domain from MIC1: A micronemal protein from Toxoplasma gondii, JOURNAL OF BIOMOLECULAR NMR, Vol: 31, Pages: 177-178, ISSN: 0925-2738

JOURNAL ARTICLE

Saouros S, Edwards-Jones B, Reiss M, Sawmynaden K, Cota E, Simpson P, Dowse TJ, Jakle U, Ramboarina S, Shivarattan T, Matthews S, Soldati-Favre Det al., 2005, A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 38583-38591, ISSN: 0021-9258

JOURNAL ARTICLE

Shivarattan T, Chen HA, Simpson P, Sedgwick B, Matthews Set al., 2005, Resonance assignments of Escherichia coli AlkB: a key 2-oxoglutarate and Fe(II) dependent dioxygenase of the adaptive DNA-repair response, JOURNAL OF BIOMOLECULAR NMR, Vol: 33, Pages: 138-138, ISSN: 0925-2738

JOURNAL ARTICLE

Szendroi A, Simpson P, Ghuman J, Matthews S, Curry Set al., 2005, Structural and functional analyses of eukaryotic initiation factor 4B (eIF4B) to study its role in cap-independent translation initiation of picornaviral IRESes, FEBS JOURNAL, Vol: 272, Pages: 392-393, ISSN: 1742-464X

JOURNAL ARTICLE

Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RAG, Nowicki B, Le Bouguenec C, Lea SM, Matthews Set al., 2004, An atomic resolution model for assembly, architecture, and function of the Dr adhesins, MOLECULAR CELL, Vol: 15, Pages: 647-657, ISSN: 1097-2765

JOURNAL ARTICLE

Anderson KL, Cota E, Simpson P, Chen HA, du Merle L, Le Bouguenec C, Matthews Set al., 2004, Letter to the Editor: Complete resonance assignments of a 'donor-strand complemented' AfaE: The afimbrial adhesin from Diffusely Adherent E-coli, JOURNAL OF BIOMOLECULAR NMR, Vol: 29, Pages: 409-410, ISSN: 0925-2738

JOURNAL ARTICLE

Cota E, Chen HA, Anderson KL, Simpson P, du Merle L, Bernier-Febreau C, Piaatek R, Zalewska B, Nowicki B, Kur J, Le Bouguenec C, Matthews Set al., 2004, Letter to the Editor: Complete resonance assignments of the 'donor-strand complemented' AfaD: The afimbrial invasin from Diffusely Adherent E-coli, JOURNAL OF BIOMOLECULAR NMR, Vol: 29, Pages: 411-412, ISSN: 0925-2738

JOURNAL ARTICLE

Dreveny I, Pye VE, Beuron F, Briggs LC, Isaacson RL, Matthews SJ, McKeown C, Yuan X, Zhang X, Freemont PSet al., 2004, P97 and close encounters of every kind: a brief review, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 32, Pages: 715-720, ISSN: 0300-5127

JOURNAL ARTICLE

Fleming K, Matthews S, 2004, Media for studies of partially aligned states., Methods Mol Biol, Vol: 278, Pages: 79-88, ISSN: 1064-3745

Measurement of residual dipolar couplings for proteins in nuclear magnetic resonance (NMR) requires a degree of molecular alignment. This may be achieved through the use of liquid crystals or compressed hydrated gels. Several media have been described in the literature, and this chapter describes five of the most commonly used systems. For two of these systems, bicelles and filamentous bacteriophage, the media can be purchased in a form ready for experiments. The remainder must be made by the investigator, yet they are generally straightforward to synthesize in the laboratory. Poly(ethylene glycol)/alcohol mixtures and Helfrich phases are made by simply mixing the ingredients in the correct manner, and strained gels use techniques familiar to all molecular biologists.

JOURNAL ARTICLE

Matthews S, 2004, Perdeuteration/site-specific protonation approaches for high-molecular-weight proteins., Methods Mol Biol, Vol: 278, Pages: 35-45, ISSN: 1064-3745

Among the factors that limit the application of nuclear magnetic resonance (NMR) to biological macromolecules are increasing resonance overlap and fast transverse relaxation. Multidimensional NMR combined with 13C and 15N labeling has alleviated these problems temporarily; however, they resurface at molecular weight (mol wt) in excess of 30 kDa. Combined perdeuteration/site-specific protonation together with segmental labeling, transverse relaxation-optimized spectroscopy (TROSY), and residual dipolar couplings have all helped to dramatically extend the mol wt limit. This article describes some of the practical aspects of the combined perdeuteration/site-specific protonation approach, which has proved so useful in the global fold determination of large proteins.

JOURNAL ARTICLE

Matthews S, 2004, NMR of proteins and nucleic acids, RSc Special Periodical Reports, Editors: webb, Pages: 326-356

BOOK CHAPTER

Pettigrew D, Anderson KL, Billington J, Cota E, Simpson P, Urvil P, Rabuzin F, Roversi P, Nowicki B, du Merle L, Le Bouguenec C, Matthews S, Lea SMet al., 2004, High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 46851-46857, ISSN: 0021-9258

JOURNAL ARTICLE

Pettigrew D, Roversi P, Bhella D, Billington J, Anderson KL, Cota E, Nowicki B, Le Bouguenec C, Medof E, Smith RAG, Barlow PN, Matthews S, Lea SMet al., 2004, Structural studies of CD55 interactions with pathogen-derived ligands, MOLECULAR IMMUNOLOGY, Vol: 41, Pages: 293-293, ISSN: 0161-5890

JOURNAL ARTICLE

Prasannan S, Simpson P, Wilson RK, Crepin VF, Frankel G, Matthews Set al., 2004, Letter to the Editor: H-1, C-13, and N-15 resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic E-coli (EPEC), JOURNAL OF BIOMOLECULAR NMR, Vol: 30, Pages: 387-388, ISSN: 0925-2738

JOURNAL ARTICLE

Prasannan S, Simpson P, Wilson RK, Crepin VF, Frankel G, Matthews Set al., 2004, (1)H, (13)C, and (15)N resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic E. coli (EPEC)., J Biomol NMR, Vol: 30, Pages: 387-388, ISSN: 0925-2738

JOURNAL ARTICLE

Ramboarina S, Fernandes P, Simpson P, Frankel G, Donnenberg M, Matthews Set al., 2004, Letter to the Editor: Complete resonance assignments of bundlin (BfpA) from the bundle-forming pilus of enteropathogenic Escherichia coli, JOURNAL OF BIOMOLECULAR NMR, Vol: 29, Pages: 427-428, ISSN: 0925-2738

JOURNAL ARTICLE

Ramboarina S, Fernandes P, Simpson P, Frankel G, Donnenberg M, Matthews Set al., 2004, Complete resonance assignments of bundlin (BfpA) from the bundle-forming pilus of enteropathogenic Escherichia coli., J Biomol NMR, Vol: 29, Pages: 427-428, ISSN: 0925-2738

JOURNAL ARTICLE

Simpson PJ, Monie TP, Szendroi A, Davydova N, Tyzack JK, Conte MR, Read CM, Cary PD, Svergun DI, Konarev PV, Curry S, Matthews Set al., 2004, Structure and RNA interactions of the N-terminal RRM domains of PTB, STRUCTURE, Vol: 12, Pages: 1631-1643, ISSN: 0969-2126

JOURNAL ARTICLE

Yuan XM, Simpson P, Kondo H, Mckeown C, Dreveny I, Zhang XD, Freemont PS, Matthews Set al., 2004, Letter to the Editor: Complete backbone resonance assignments of p47: The 41kDa adaptor protein of the AAA ATPase p97, JOURNAL OF BIOMOLECULAR NMR, Vol: 28, Pages: 309-310, ISSN: 0925-2738

JOURNAL ARTICLE

Yuan XM, Simpson P, Mckeown C, Kondo H, Uchiyama K, Wallis R, Dreveny I, Keetch C, Zhang XD, Robinson C, Freemont P, Matthews Set al., 2004, Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97, EMBO JOURNAL, Vol: 23, Pages: 1463-1473, ISSN: 0261-4189

JOURNAL ARTICLE

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