Imperial College London

Prof Steve Matthews

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Chemical and Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 5315s.j.matthews Website

 
 
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Location

 

Room 602Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

190 results found

GILLIES DG, MATTHEWS SJ, SUTCLIFFE LH, 1992, COMPARISON OF THE WOESSNER AND THE MODEL-FREE APPROACHES FOR THE ANALYSIS OF C-13 SPIN-LATTICE RELAXATION DATA FOR METHYL-GROUPS, MAGNETIC RESONANCE IN CHEMISTRY, Vol: 30, Pages: 259-262, ISSN: 0749-1581

JOURNAL ARTICLE

Gillies DG, Matthews SJ, Sutcliffe LH, 1992, Variable temperature, frequency and high pressure carbon-13 NMR relaxation studies of a traction fluid and some of its analogues, Journal of Molecular Liquids, Vol: 54, Pages: 181-191, ISSN: 0167-7322

JOURNAL ARTICLE

LEATHERBARROW RJ, MATTHEWS SJ, 1992, C-13 NUCLEAR-MAGNETIC-RESONANCE RELAXATION STUDY OF CHYMOTRYPSIN INHIBITOR-2 (CI-2), MAGNETIC RESONANCE IN CHEMISTRY, Vol: 30, Pages: 1255-1260, ISSN: 0749-1581

JOURNAL ARTICLE

BULL LM, GILLIES DG, MATTHEWS SJ, SUTCLIFFE LH, WILLIAMS AJet al., 1991, C-13 NMR RELAXATION STUDY OF THE OVERALL AND INTERNAL MOTIONS IN COMPOUNDS CONTAINING NORMAL-OCTYL CHAINS, MAGNETIC RESONANCE IN CHEMISTRY, Vol: 29, Pages: 273-281, ISSN: 0749-1581

JOURNAL ARTICLE

GILLIES DG, MATTHEWS SJ, SUTCLIFFE LH, 1991, C-13 NMR RELAXATION STUDIES OF SOME DICYCLOHEXYL COMPOUNDS AT HIGH-PRESSURE, MAGNETIC RESONANCE IN CHEMISTRY, Vol: 29, Pages: 823-829, ISSN: 0749-1581

JOURNAL ARTICLE

GILLIES DG, MATTHEWS SJ, SUTCLIFFE LH, 1991, MULTIFREQUENCY, VARIABLE-TEMPERATURE AND HIGH-PRESSURE STUDY OF C-13 SPIN-LATTICE RELAXATION IN TETRAOCTYLTIN, MAGNETIC RESONANCE IN CHEMISTRY, Vol: 29, Pages: 1221-1225, ISSN: 0749-1581

JOURNAL ARTICLE

GILLIES DG, MATTHEWS SJ, SUTCLIFFE LH, 1991, C-13 NMR RELAXATION STUDIES OF SOME DICYCLOHEXYL COMPOUNDS, MAGNETIC RESONANCE IN CHEMISTRY, Vol: 29, Pages: 777-785, ISSN: 0749-1581

JOURNAL ARTICLE

GILLIES DG, MATTHEWS SJ, SUTCLIFFE LH, 1990, C-13 NMR-STUDY OF THE OVERALL AND INTERNAL MOTIONS OF A SEMIRIGID HYDROCARBON, MAGNETIC RESONANCE IN CHEMISTRY, Vol: 28, Pages: 171-175, ISSN: 0749-1581

JOURNAL ARTICLE

GILLIES DG, MATTHEWS SJ, SUTCLIFFE LH, WILLIAMS AJet al., 1990, THE EVALUATION OF 2 CORRELATION TIMES FOR METHYL-GROUPS FROM C-13 SPIN-LATTICE RELAXATION-TIMES AND NOE DATA, JOURNAL OF MAGNETIC RESONANCE, Vol: 86, Pages: 371-375, ISSN: 0022-2364

JOURNAL ARTICLE

Taylor JD, Matthews SJ, New insight into the molecular control of bacterial functional amyloids., Frontiers in Cellular and Infection Microbiology, Vol: 5, ISSN: 2235-2988

Amyloid protein structure has been discovered in a variety of functional or pathogenic contexts. What distinguishes the former from the latter is that functional amyloid systems possess dedicated molecular control systems that determine the timing, location, and structure of the fibers. Failure to guide this process can result in cytotoxicity, as observed in several pathologies like Alzheimer's and Parkinson's Disease. Many gram-negative bacteria produce an extracellular amyloid fiber known as curli via a multi-component secretion system. During this process, aggregation-prone, semi-folded curli subunits have to cross the periplasm and outer-membrane and self-assemble into surface-attached fibers. Two recent breakthroughs have provided molecular details regarding periplasmic chaperoning and subunit secretion. This review offers a combined perspective on these first mechanistic insights into the curli system.

JOURNAL ARTICLE

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