Imperial College London
Alternate

Prof Steve Matthews

Faculty of Natural Sciences, Department of Life Sciences

Professor of Chemical and Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 5315s.j.matthews Website

 
 
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Location

 

602Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Taylor:2016:10.1016/j.jmb.2016.01.013,
author = {Taylor, J and Taylor, G and Hare, S and Matthews, SJ},
doi = {10.1016/j.jmb.2016.01.013},
journal = {Journal of Molecular Biology},
pages = {554--560},
title = {Structures of the DfsB protein family suggest a cationic, helical sibling-lethal factor peptide},
url = {http://dx.doi.org/10.1016/j.jmb.2016.01.013},
volume = {428},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bacteria have developed a variety of mechanisms for survivingharsh environmental conditions, nutrient stress and overpopulation.Paenibacillus dendritiformis produces a lethal protein (Slf) that is ableto induce cell death in neighboring colonies and a phenotypic switch inmore distant ones. Slf is derived from the secreted precursor protein,DfsB, after proteolytic processing. Here, we present new crystalstructures of DfsB homologues from a variety of bacterial species and asurprising version present in the yeast Saccharomyces cerevisiae.Adopting a four-helix bundle decorated with a further three short heliceswithin intervening loops, DfsB belongs to a non-enzymatic class of theDinB fold. The structure suggests that the biologically-active Slffragment may possess a C-terminal helix rich in basic and aromaticresidues that suggest a functional mechanism akin to that for cationicantimicrobial peptides.
AU  - Taylor,J
AU  - Taylor,G
AU  - Hare,S
AU  - Matthews,SJ
DO  - 10.1016/j.jmb.2016.01.013
EP  - 560
PY  - 2016///
SN  - 1089-8638
SP  - 554
TI  - Structures of the DfsB protein family suggest a cationic, helical sibling-lethal factor peptide
T2  - Journal of Molecular Biology
UR  - http://dx.doi.org/10.1016/j.jmb.2016.01.013
UR  - http://hdl.handle.net/10044/1/28977
VL  - 428
ER  -
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