Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

546 results found

Mallia P, Johnston SL, 2002, Respiratory viruses: do they protect from or induce asthma?, ALLERGY, Vol: 57, Pages: 1118-1129, ISSN: 0105-4538

Journal article

Pala P, Message SD, Johnston SL, Openshaw PJMet al., 2002, Increased aeroallergen-specific interleukin-4-producing T cells in asthmatic adults, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 32, Pages: 1739-1744, ISSN: 0954-7894

Journal article

Seemungal TAR, Wedzicha JA, MacCallum PK, Johnston SL, Lambert PAet al., 2002, Chlamydia pneumoniae and COPD exacerbation, THORAX, Vol: 57, Pages: 1087-1088, ISSN: 0040-6376

Journal article

Wark PAB, Johnston SL, Simpson JL, Hensley MJ, Gibson PGet al., 2002, Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 20, Pages: 834-840, ISSN: 0903-1936

Journal article

Papi A, Papadopoulos NG, Stanciu LA, Bellettato CM, Pinamonti S, Degitz K, Holgate ST, Johnston SLet al., 2002, Reducing agents inhibit rhinovirus-induced up-regulation of the rhinovirus receptor intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells, FASEB JOURNAL, Vol: 16, Pages: 1934-+, ISSN: 0892-6638

Journal article

Johnston SL, Seymour ML, Gilby N, Bardin PG, Fraenkel DJ, Sanderson G, Penrose JF, Holgate ST, Sampson APet al., 2002, Beneficial effect of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with asthma during viral infection - Reply, JOURNAL OF INFECTIOUS DISEASES, Vol: 186, Pages: 723-724, ISSN: 0022-1899

Journal article

Blair ED, Killington RA, Rowlands DJ, Clarke NJ, Johnston SLet al., 2002, Transgenic animal models of HRV with human ICAM-1 sequences., International patent application No. PCT/EP2003/007939, 17 July 2003

Patent

Bossios A, Gourgiotis D, Psarras S, Volonaki E, Johnston SL, Saxoni-Papageorgiou F, Papadopoulos NGet al., 2002, Induction of eotaxin and eotaxin-2 in nasal secretions of patients with seasonal respiratory allergy, 21st Congress of the European-Academy-of-Allergology-and-Clinical-Immunology, Publisher: BLACKWELL MUNKSGAARD, Pages: 126-127, ISSN: 0105-4538

Conference paper

Psarras S, Xatzipsalti M, Volonaki E, Bossios A, Gourgiotis D, Saxoni-Papageorgiou F, Johnston SL, Papadopoulos NGet al., 2002, Rhinovirus infection stimulates production of fibroblast growth factor-2 by airway epithelial and stromal cells, 21st Congress of the European-Academy-of-Allergology-and-Clinical-Immunology, Publisher: BLACKWELL MUNKSGAARD, Pages: 296-296, ISSN: 0105-4538

Conference paper

Legg JP, Jones CA, Warner JA, Johnston SL, Warner JOet al., 2002, A hypothesis: antenatal sensitisation to respiratory syncytial virus in viral bronchiolitis, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 86, Pages: 431-433, ISSN: 0003-9888

Journal article

Legg JP, Jones CA, Warner JA, Johnston SL, Warner JOet al., 2002, A hypothesis: antenatal sensitisation to respiratory syncytial virus in viral bronchiolitis., Arch Dis Child, Vol: 86, Pages: 431-433

AIM: To investigate the possibility of antenatal sensitisation to respiratory syncytial virus (RSV). METHODS: A total of 36 cord blood specimens were obtained from newborn infants; serum IgA was measured to exclude maternal blood contamination. Cord peripheral blood mononuclear cells were separated and cultured in the presence of either uninfected negative control cells or cells containing ultraviolet (UV) inactivated RSV. Proliferation was assessed by tritiated thymidine incorporation. Supernatant cytokine concentrations were measured using ELISA. RESULTS: Significantly higher proliferative response rates to UV inactivated RSV were shown in those infants exposed in utero to the RSV epidemic after 22 weeks gestation. UV inactivated RSV stimulation induced significantly higher interferon gamma production from specimens with a positive proliferative response (sensitised) than from those with a negative response (not sensitised). CONCLUSIONS: Antenatal sensitisation to RSV occurs in one third of infants exposed to an RSV epidemic at the appropriate time of gestation. This sensitisation is associated with increased interferon gamma production, suggesting a type 1 memory response. We hypothesise that priming of fetal T cells to RSV results in a reduced severity of subsequent RSV disease in these individuals and that this will explain much of the clinical diversity of RSV disease.

Journal article

Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SLet al., 2002, A defective type 1 response to rhinovirus in atopic asthma, THORAX, Vol: 57, Pages: 328-332, ISSN: 0040-6376

Journal article

Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SLet al., 2002, Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 32, Pages: 537-542, ISSN: 0954-7894

Journal article

Green RM, Cusotvic A, Sanderson G, Hunter J, Johnston SL, Woodcock Aet al., 2002, Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study, BMJ-BRITISH MEDICAL JOURNAL, Vol: 324, Pages: 763-766A, ISSN: 1756-1833

Journal article

Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, Holgate ST, Johnston SLet al., 2002, Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study, LANCET, Vol: 359, Pages: 831-834, ISSN: 0140-6736

Journal article

Cho SH, Stanciu LA, Begishivili T, Bates PJ, Holgate ST, Johnston SLet al., 2002, Peripheral blood CD4(+) and CD8(+) T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 32, Pages: 427-433, ISSN: 0954-7894

Journal article

Seymour ML, Gilby N, Bardin PG, Fraenkel DJ, Sanderson G, Penrose JF, Holgate ST, Johnston SL, Sampson APet al., 2002, Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects, JOURNAL OF INFECTIOUS DISEASES, Vol: 185, Pages: 540-544, ISSN: 0022-1899

Journal article

Johnston SL, 2002, Anti-influenza therapies, VIRUS RESEARCH, Vol: 82, Pages: 147-152, ISSN: 0168-1702

Journal article

Umland SP, Schleimer RP, Johnston SL, 2002, Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma, PULMONARY PHARMACOLOGY & THERAPEUTICS, Vol: 15, Pages: 35-50, ISSN: 1094-5539

Journal article

Wark PAB, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PGet al., 2002, Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 19, Pages: 68-75, ISSN: 0903-1936

Journal article

Johnston SL, 2002, Associations with blood pressure in Blackfeet women., Publisher: WILEY-LISS, Pages: 91-91, ISSN: 0002-9483

Conference paper

Message SD, Johnston SL, 2002, Viruses in asthma, BRITISH MEDICAL BULLETIN, Vol: 61, Pages: 29-43, ISSN: 0007-1420

Journal article

Message SD, Johnston SL, 2002, Triggers of Asthma and COPD - Infections, Asthma and COPD: basic mechanisms and clinical management, Editors: Barnes, Drazen, Rennard, Thomson, London, Publisher: Academic Press, Pages: 407-420, ISBN: 9780120790289

Book chapter

Legg JP, Johnston SL, 2002, Respiratory syncytial virus infection: determinants of disease severity, Clin Pulm Med, Vol: 9, Pages: 306-314, ISSN: 1068-0640

Journal article

Barnes PJ, 2002, What are the mechanisms of corticosteroids resistance in asthma?, Asthma: Critical debates, Pages: 241-254, ISBN: 9780632057214

Book chapter

Message SD, Johnston SL, 2001, The immunology of virus infection in asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 18, Pages: 1013-1025, ISSN: 0903-1936

Journal article

Seemungal T, Harper-Owen R, Bhowmik A, Moric I, Sanderson G, Message S, MacCallum P, Meade TW, Jeffries DJ, Johnston SL, Wedzicha JAet al., 2001, Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 164, Pages: 1618-1623, ISSN: 1073-449X

Journal article

Wark PA, Gibson PG, Johnston SL, 2001, Exacerbations of asthma: addressing the triggers and treatments., Monaldi Arch Chest Dis, Vol: 56, Pages: 429-435, ISSN: 1122-0643

Airway inflammation is known to play a crucial role in chronic asthma and has led to the effective use of anti-inflammatory treatments to control chronic asthma. Despite these improvements exacerbations of asthma continue to occur in subjects with stable disease compliant with treatment. Viral respiratory tract infections have been found to be associated with the majority of asthma exacerbations in both children and adults. Evidence is emerging that viral infections may alter the inflammatory infiltrate present in chronic asthma with a more heterogenous neutrophil/eosinophil infiltrate. The implications are that the pathogenesis of acute asthma may differ from that present in chronic asthma in important ways that may influence the effectiveness of treatment. Inhaled corticosteroids are effective in controlling chronic airway inflammation in asthma but appear not to be as effective in acute asthma. This may mean that new directions will be needed to target specifically the airway inflammation in virus-induced acute asthma.

Journal article

Johnston SL, 2001, Is Chlamydia pneumoniae important in asthma? The first controlled trial of therapy leaves the question unanswered, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 164, Pages: 513-514, ISSN: 1073-449X

Journal article

O'Sullivan S, Cormican L, Faul JL, Ichinohe S, Johnston SL, Burke CM, Poulter LWet al., 2001, Activated, cytotoxic CD8(+) T lymphocytes contribute to the pathology of asthma death, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 164, Pages: 560-564, ISSN: 1073-449X

Journal article

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