Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

527 results found

Seymour ML, Gilby N, Bardin PG, Fraenkel DJ, Sanderson G, Penrose JF, Holgate ST, Johnston SL, Sampson APet al., 2002, Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects, JOURNAL OF INFECTIOUS DISEASES, Vol: 185, Pages: 540-544, ISSN: 0022-1899

JOURNAL ARTICLE

Johnston SL, 2002, Anti-influenza therapies, VIRUS RESEARCH, Vol: 82, Pages: 147-152, ISSN: 0168-1702

JOURNAL ARTICLE

Wark PAB, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PGet al., 2002, Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 19, Pages: 68-75, ISSN: 0903-1936

JOURNAL ARTICLE

Umland SP, Schleimer RP, Johnston SL, 2002, Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma, PULMONARY PHARMACOLOGY & THERAPEUTICS, Vol: 15, Pages: 35-50, ISSN: 1094-5539

JOURNAL ARTICLE

Message SD, Johnston SL, 2002, Viruses in asthma, BRITISH MEDICAL BULLETIN, Vol: 61, Pages: 29-43, ISSN: 0007-1420

JOURNAL ARTICLE

Message SD, Johnston SL, 2002, Triggers of Asthma and COPD - Infections, Asthma and COPD: basic mechanisms and clinical management, Editors: Barnes, Drazen, Rennard, Thomson, London, Publisher: Academic Press, Pages: 407-420, ISBN: 9780120790289

BOOK CHAPTER

Message SD, Johnston SL, 2001, The immunology of virus infection in asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 18, Pages: 1013-1025, ISSN: 0903-1936

JOURNAL ARTICLE

Seemungal T, Harper-Owen R, Bhowmik A, Moric I, Sanderson G, Message S, MacCallum P, Meade TW, Jeffries DJ, Johnston SL, Wedzicha JAet al., 2001, Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 164, Pages: 1618-1623, ISSN: 1073-449X

JOURNAL ARTICLE

Wark PA, Gibson PG, Johnston SL, 2001, Exacerbations of asthma: addressing the triggers and treatments., Monaldi Arch Chest Dis, Vol: 56, Pages: 429-435, ISSN: 1122-0643

Airway inflammation is known to play a crucial role in chronic asthma and has led to the effective use of anti-inflammatory treatments to control chronic asthma. Despite these improvements exacerbations of asthma continue to occur in subjects with stable disease compliant with treatment. Viral respiratory tract infections have been found to be associated with the majority of asthma exacerbations in both children and adults. Evidence is emerging that viral infections may alter the inflammatory infiltrate present in chronic asthma with a more heterogenous neutrophil/eosinophil infiltrate. The implications are that the pathogenesis of acute asthma may differ from that present in chronic asthma in important ways that may influence the effectiveness of treatment. Inhaled corticosteroids are effective in controlling chronic airway inflammation in asthma but appear not to be as effective in acute asthma. This may mean that new directions will be needed to target specifically the airway inflammation in virus-induced acute asthma.

JOURNAL ARTICLE

Johnston SL, 2001, Is Chlamydia pneumoniae important in asthma? The first controlled trial of therapy leaves the question unanswered, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 164, Pages: 513-514, ISSN: 1073-449X

JOURNAL ARTICLE

O'Sullivan S, Cormican L, Faul JL, Ichinohe S, Johnston SL, Burke CM, Poulter LWet al., 2001, Activated, cytotoxic CD8(+) T lymphocytes contribute to the pathology of asthma death, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 164, Pages: 560-564, ISSN: 1073-449X

JOURNAL ARTICLE

Papi A, Papadopoulos NG, Stanciu LA, Degitz K, Holgate ST, Johnston SLet al., 2001, Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 108, Pages: 221-228, ISSN: 0091-6749

JOURNAL ARTICLE

Papadopoulos NG, Papi A, Meyer J, Stanciu LA, Salvi S, Holgate ST, Johnston SLet al., 2001, Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 31, Pages: 1060-1066, ISSN: 0954-7894

JOURNAL ARTICLE

Corne JM, Lau L, Scott SJ, Davies R, Johnston SL, Howarth PHet al., 2001, The relationship between atonic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 163, Pages: 1101-1107, ISSN: 1073-449X

JOURNAL ARTICLE

Stanciu LA, Roberts K, Lau LCK, Coyle AJ, Johnston SLet al., 2001, Induction of type 2 activity in adult human CD8(+) T cells by repeated stimulation and IL-4, INTERNATIONAL IMMUNOLOGY, Vol: 13, Pages: 341-348, ISSN: 0953-8178

JOURNAL ARTICLE

Papadopoulos NG, Johnston SL, 2001, The role of viruses in the induction and progression of asthma., Curr Allergy Asthma Rep, Vol: 1, Pages: 144-152, ISSN: 1529-7322

Viral respiratory infections have been related to asthma in several ways. It is well established that viral common colds precipitate exacerbations of asthma. Severe bronchiolitis in early life is related to subsequent wheezing and therefore may represent a marker of susceptibility to asthma; alternatively, it could be involved in the initiation of the disease. Finally, it is possible that some infections may protect from the development of asthma and allergies by promoting a type-1 host response. However, whether respiratory or other viruses could mediate such a protective effect is debated. The design and implementation of novel anti- or proviral strategies targeting asthma depends on the resolution of these questions. This review presents current evidence on the epidemiologic correlations and proposed mechanisms for the involvement of viral infections in the development and progression of asthma.

JOURNAL ARTICLE

Johnston SL, Openshaw PJM, 2001, The protective effect of childhood infections - The next challenge is to mimic safely this protection against allergy and asthma, BRITISH MEDICAL JOURNAL, Vol: 322, Pages: 376-377, ISSN: 0959-8138

JOURNAL ARTICLE

Stanciu LA, Laza-Stanca V, Coyle AJ, Johnston SLet al., 2001, IL-4 decreases antiviral chemokine production by CD8(+) T cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 107, Pages: S80-S80, ISSN: 0091-6749

JOURNAL ARTICLE

Papadopoulos NG, Johnston SL, 2001, The rhinovirus - not such an innocent?, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 94, Pages: 1-3, ISSN: 1460-2725

JOURNAL ARTICLE

Gravenstein S, Johnston SL, Loeschel E, Webster Aet al., 2001, Zanamivir - A review of clinical safety in individuals at high risk of developing influenza-related complications, DRUG SAFETY, Vol: 24, Pages: 1113-1125, ISSN: 0114-5916

JOURNAL ARTICLE

Papadopoulos NG, Johnston SL, 2001, Viral infections of the nose and lung, Eur Respir Mon, Vol: 6, Pages: 79-100, ISSN: 1025-448X

JOURNAL ARTICLE

Corne JM, Johnston SL, Beasley R, 2001, Evidence for upper respiratory tract viruses as precipitants for asthma exacerbations, Asthma and Respiratory Infections, Editors: Skoner, New York, Publisher: Marcel Dekker, Inc, Pages: 45-62

BOOK CHAPTER

Corne JM, Johnston SL, Beasley R, 2001, Rates of asthma exacerbations during viral respiratory infection, ISBN: 9780824777104

BOOK CHAPTER

Chauhan AJ, Johnston SL, 2001, Advances in the diagnosis of respiratory virus infectons, Asthma and Respiratory Infections, Editors: Skoner, Publisher: Marcek Dekker, Pages: 221-243, ISBN: 9780824777104

BOOK CHAPTER

Creer D, Johnston SL, 2001, Influenza: the practical implications of diagnosis, Pract Nursing, Vol: 12, Pages: 399-402, ISSN: 0964-9271

JOURNAL ARTICLE

Johnston SL, 2001, Asthma: critical debates, ISBN: 9780632057214

BOOK

Rosenberg M, Johnston S L, 2001, Anti-infective challenges in the 21st century: from superbugs to viral pandemics, Current Opinion in Pharmacology, Vol: 1, Pages: 449-450

JOURNAL ARTICLE

Green RM, Custovic A, Sanderson G, Hunter J, Chapman M, Brutsche M, Johnston SL, Woodcock Aet al., 2000, Prospective case-control study of adults admitted to hospital with acute asthma., THORAX, Vol: 55, Pages: A3-A3, ISSN: 0040-6376

JOURNAL ARTICLE

Bardin PG, Fraenkel DJ, Sanderson G, van Schalkwyk EM, Holgate ST, Johnston SLet al., 2000, Peak expiratory flow changes during experimental rhinovirus infection, EUROPEAN RESPIRATORY JOURNAL, Vol: 16, Pages: 980-985, ISSN: 0903-1936

JOURNAL ARTICLE

Papadopoulos NG, Johnston SL, 2000, Rhinoviruses as pathogens of the lower respiratory tract., Can Respir J, Vol: 7, Pages: 409-414, ISSN: 1198-2241

Rhinoviruses (RVs) are the most common upper respiratory pathogens, inducing the majority of common colds worldwide. RV-related morbidity, although significant cumulatively, has been considered trivial for the individual patient. However, recent strong epidemiological associations of RVs with asthma exacerbations, including severe episodes requiring hospitalization, indicate that RV infections can result in serious disease. Current evidence supports the possibility that RVs infect the lower airways, inducing a local inflammatory response. Such evidence suggests that the role of RVs in other lower respiratory diseases, such as pneumonia, bronchitis, bronchiolitis and cystic fibrosis, should be re-examined with polymerase chain reaction-based methodologies, which are considerably more sensitive than traditional, cell culture-based techniques. The mechanisms through which RVs induce lower airway disease are studied to understand the relative contributions of the epithelial, neurogenic and immune components in the antiviral response, and to permit the design and implementation of specific treatments.

JOURNAL ARTICLE

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