527 results found
Hanratty CE, Matthews JG, Arron JR, et al., 2018, A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial, TRIALS, Vol: 19, ISSN: 1745-6215
Dhariwal J, Wong E, Trujillo-Torralbo B, et al., 2018, Poor Baseline Asthma Control Is Associated with Greater Virus Load Following Rhinovirus Infection, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Ritchie AI, Singanayagam A, Wiater E, et al., 2018, beta(2)-agonists enhance asthma-relevant inflammatory mediators in human airway epithelial cells, American Journal of Respiratory Cell and Molecular Biology, Vol: 58, Pages: 128-132, ISSN: 1044-1549
Edwards MR, Walton RP, Jackson DJ, et al., 2018, The potential of anti-infectives and immunomodulators as therapies for asthma and asthma exacerbations, ALLERGY, Vol: 73, Pages: 50-63, ISSN: 0105-4538
Tang HHF, Teo SM, Belgrave DCM, et al., 2017, Non-parametric mixture models identify trajectories of childhood immune development relevant to asthma and allergy
Events in early life contribute to subsequent risk of asthma; however, the causes and trajectories of childhood wheeze are heterogeneous and do not always result in asthma. Similarly, not all atopic individuals develop wheeze, and vice versa. The reasons for these differences are unclear. Using unsupervised model-based cluster analysis, we identified latent clusters within a prospective birth cohort with deep immunological and respiratory phenotyping. We characterised each cluster in terms of immunological profile and disease risk, and replicated our results in external cohorts from the UK and USA. We discovered three distinct trajectories, one of which is a high-risk "atopic" cluster with increased propensity for allergic diseases throughout childhood. Atopy contributes varyingly to later wheeze depending on cluster membership. Our findings demonstrate the utility of unsupervised analysis in elucidating heterogeneity in asthma pathogenesis and provide a foundation for improving management and prevention of childhood asthma.
Finney LJ, Belchamber K, Kemp S, et al., 2017, HUMAN RHINOVIRUS IMPAIRS PHAGOCYTOSIS OF HAEMOPHILUS INFLUENZAE IN ALVEOLAR MACROPHAGES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A112-A112, ISSN: 0040-6376
Teo SM, Tang HHF, Mok D, et al., 2017, Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children, Biorxiv
Repeated cycles of infection-associated lower airway inflammation drives the pathogenesis of persistent wheezing disease in children. Tracking these events across a birth cohort during their first five years, we demonstrate that >80% of infectious events indeed involve viral pathogens, but are accompanied by a shift in the nasopharyngeal microbiome (NPM) towards dominance by a small range of pathogenic bacterial genera. Unexpectedly, this change in NPM frequently precedes the appearance of viral pathogens and acute symptoms. In non-sensitized children these events are associated only with "transient wheeze" that resolves after age three. In contrast, in children developing early allergic sensitization, they are associated with ensuing development of persistent wheeze, which is the hallmark of the asthma phenotype. This suggests underlying pathogenic interactions between allergic sensitization and anti-bacterial mechanisms.
Toussaint M, Jackson DJ, Swieboda D, et al., 2017, Corrigendum: Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation., Nat Med, Vol: 23, Pages: 1384-1384
This corrects the article DOI: 10.1038/nm.4332.
Vasileiou E, Sheikh A, Butler C, et al., 2017, Effectiveness of Influenza Vaccines in Asthma: A Systematic Review and Meta-Analysis, CLINICAL INFECTIOUS DISEASES, Vol: 65, Pages: 1388-1395, ISSN: 1058-4838
Edwards MR, Strong K, Cameron A, et al., 2017, Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 140, Pages: 909-920, ISSN: 0091-6749
Farne HA, Johnston SL, 2017, Immune mechanisms of respiratory viral infections in asthma, CURRENT OPINION IN IMMUNOLOGY, Vol: 48, Pages: 31-37, ISSN: 0952-7915
Hellings PW, Fokkens WJ, Bachert C, et al., 2017, Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis - A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement, ALLERGY, Vol: 72, Pages: 1297-1305, ISSN: 0105-4538
Upton N, Jackson DJ, Nikonova AA, et al., 2017, Rhinovirus induction of fractalkine (CX3CL1) in airway and peripheral blood mononuclear cells in asthma, PLOS ONE, Vol: 12, ISSN: 1932-6203
Haldar K, Bafadhel M, Lau K, et al., 2017, Microbiome balance in sputum determined by PCR stratifies COPD exacerbations and shows potential for selective use of antibiotics, PLOS ONE, Vol: 12, ISSN: 1932-6203
Jha A, Jarvis H, Fraser C, et al., 2017, Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) infection has an estimated global incidence of 33 million cases in children younger than 5 years, with 10% requiring hospital admission and up to 199,000 dying of the disease. There is growing evidence that severe infantile RSV bronchiolitis, a condition characterised by an inflammatory reaction to the virus, is associated with later childhood wheeze in some vulnerable children; however, a direct causal relationship with asthma has not yet been established. It is also increasingly recognised as a cause of morbidity and mortality in those with underlying airway disease, immunocompromise and frail elderly persons. Novel molecular based diagnostic tools are becoming established but treatment largely remains supportive, with palivizumab being the only licensed agent currently available for passive prophylaxis of selected pre-term infants. Whilst effective treatments remain elusive, there is optimism about the testing of novel antiviral drugs and the development of vaccines that may induce long-lasting immunity without the risk of disease augmentation.
Dhariwal J, Cameron A, Trujillo-Torralbo M-B, et al., 2017, Mucosal Type 2 Innate Lymphoid Cells Are a Key Component of the Allergic Response to Aeroallergens, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 195, Pages: 1586-1596, ISSN: 1073-449X
Petrova NV, Emelyanova AG, Gorbunov EA, et al., 2017, Efficacy of novel antibody-based drugs against rhinovirus infection: In vitro and in vivo results, ANTIVIRAL RESEARCH, Vol: 142, Pages: 185-192, ISSN: 0166-3542
Toussaint M, Jackson DJ, Swieboda D, et al., 2017, Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation, NATURE MEDICINE, Vol: 23, Pages: 681-+, ISSN: 1078-8956
Prakash R, Hallett IC, Wong SF, et al., 2017, Cell separation in kiwifruit without development of a specialised detachment zone, BMC PLANT BIOLOGY, Vol: 17, ISSN: 1471-2229
Toussaint M, Swieboda D, Guedan A, et al., NETosis and associated host DNA orchestrate rhinovirus-induced type 2 allergic asthma exacerbation, Nature Medicine, ISSN: 1546-170X
Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of type 2 immunity is strongly implicated in asthma exacerbation, but how virus infection boosts type 2 responses during exacerbation is poorly understood. We report a significant correlation between release of host double stranded DNA (dsDNA) following rhinovirus infection and exacerbation of type 2 allergic inflammation and disease severity in patients. In a mouse model, we show that rhinovirus infection triggers neutrophil extracellular traps (NETs) formation and host dsDNA release. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or degrading NETs with DNase protects mice from type 2 allergic asthma exacerbations. Furthermore, injection of host dsDNA alone is sufficient to recapitulate many features of rhinovirus-induced type 2 immune responses and asthma pathology. Thus, NETosis and host dsDNA contribute to exacerbation pathogenesis and may represent potential targets for novel treatments of rhinovirus-induced asthma exacerbations.
Papadopoulos NG, Androutsopoulou A, Akdis C, et al., 2017, Asthma research in Europe: a transformative agenda for innovation and competitiveness, EUROPEAN RESPIRATORY JOURNAL, Vol: 49, ISSN: 0903-1936
Hansel TT, Tunstall T, Trujillo-Torralbo M-B, et al., 2017, A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-gamma and IFN-lambda) and Type 2 Inflammation (IL-5 and IL-13), EBIOMEDICINE, Vol: 19, Pages: 128-138, ISSN: 2352-3964
Guedan A, Swieboda D, Charles M, et al., 2017, Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication, JOURNAL OF VIROLOGY, Vol: 91, ISSN: 0022-538X
Edwards MR, Saglani S, Schwarze J, et al., 2017, Addressing unmet needs in understanding asthma mechanisms, EUROPEAN RESPIRATORY JOURNAL, Vol: 49, ISSN: 0903-1936
Naveed S-U-N, Clements D, Jackson DJ, et al., 2017, Matrix Metalloproteinase-1 Activation Contributes to Airway Smooth Muscle Growth and Asthma Severity, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 195, Pages: 1000-1009, ISSN: 1073-449X
Johnston SL, Mansur A, Chauhan A, 2017, Incorrect Conclusions Concerning Antibiotics and Asthma Exacerbation, JAMA INTERNAL MEDICINE, Vol: 177, Pages: 598-598, ISSN: 2168-6106
da Silva J, Hilzendeger C, Moermans C, et al., 2017, Raised interferon-beta, type 3 interferon and interferon-stimulated genes - evidence of innate immune activation in neutrophilic asthma, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 47, Pages: 313-323, ISSN: 0954-7894
Bousquet J, Farrell J, Crooks G, et al., 2017, Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (vol 6, 29, 2016), CLINICAL AND TRANSLATIONAL ALLERGY, Vol: 7, ISSN: 2045-7022
Aab A, Wirz O, van de Veen W, et al., 2017, Human rhinoviruses enter and induce proliferation of B lymphocytes, ALLERGY, Vol: 72, Pages: 232-243, ISSN: 0105-4538
Singanayagam A, Ritchie AI, Johnston SL, 2017, Role of microbiome in the pathophysiology and disease course of asthma, CURRENT OPINION IN PULMONARY MEDICINE, Vol: 23, Pages: 41-47, ISSN: 1070-5287
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