Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

471 results found

Williams GR, Kubajewska I, Glanville N, Johnston SL, Mclean GRet al., 2016, The potential for a protective vaccine for rhinovirus infections, EXPERT REVIEW OF VACCINES, Vol: 15, Pages: 569-571, ISSN: 1476-0584

JOURNAL ARTICLE

Schogler A, Stokes AB, Casaulta C, Regamey N, Edwards MR, Johnston SL, Jung A, Moeller A, Geiser T, Alves MPet al., 2016, Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection, JOURNAL OF CYSTIC FIBROSIS, Vol: 15, Pages: 332-339, ISSN: 1569-1993

JOURNAL ARTICLE

Singanayagam A, Johnston SL, 2016, Smoke and viruses - a hindrance to relaxing the airways?, CLINICAL SCIENCE, Vol: 130, Pages: 839-841, ISSN: 0143-5221

JOURNAL ARTICLE

Wolsk HM, Folsgaard NV, Birch S, Brix S, Hansel TT, Johnston SL, Kebadze T, Chawes BL, Bonnelykke K, Bisgaard Het al., 2016, Picornavirus-Induced Airway Mucosa Immune Profile in Asymptomatic Neonates, JOURNAL OF INFECTIOUS DISEASES, Vol: 213, Pages: 1262-1270, ISSN: 0022-1899

JOURNAL ARTICLE

Hewitt R, Farne H, Ritchie A, Luke E, Johnston SL, Mallia Pet al., 2016, The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma, THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, Vol: 10, Pages: 158-174, ISSN: 1753-4658

JOURNAL ARTICLE

Wang Z, Bafadhel M, Haldar K, Spivak A, Mayhew D, Miller BE, Tal-Singer R, Johnston SL, Ramsheh MY, Barer MR, Brightling CE, Brown JRet al., 2016, Lung microbiome dynamics in COPD exacerbations, EUROPEAN RESPIRATORY JOURNAL, Vol: 47, Pages: 1082-1092, ISSN: 0903-1936

JOURNAL ARTICLE

Ritchie AI, Jackson DJ, Edwards MR, Johnston SLet al., 2016, Airway Epithelial Orchestration of Innate Immune Function in Response to Virus Infection A Focus on Asthma, ANNALS OF THE AMERICAN THORACIC SOCIETY, Vol: 13, Pages: S55-S63, ISSN: 1546-3222

JOURNAL ARTICLE

Jozwik A, Habibi MS, Paras A, Zhu J, Guvenel A, Dhariwal J, Almond M, Wong EHC, Sykes A, Maybeno M, Del Rosario J, Trujillo-Torralbo M-B, Mallia P, Sidney J, Peters B, Kon OM, Sette A, Johnston SL, Openshaw PJ, Chiu Cet al., 2016, RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection (vol 6, 10224, 2015), NATURE COMMUNICATIONS, Vol: 7, ISSN: 2041-1723

JOURNAL ARTICLE

Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R, Arron JR, Choy DF, Cowan D, Mansur A, Menzies-Gow A, Adcock I, Chung KF, Corrigan C, Coyle P, Harrison T, Johnston S, Howarth P, Lordan J, Sabroe I, Bigler J, Smith D, Catley M, May R, Pierre L, Stevenson C, Crater G, Keane F, Costello RW, Hudson V, Supple D, Hardman Tet al., 2016, Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK), THORAX, Vol: 71, Pages: 187-189, ISSN: 0040-6376

JOURNAL ARTICLE

Edwards MR, Facchinetti F, Civelli M, Villetti G, Johnston SLet al., 2016, Anti-inflammatory effects of the novel inhaled phosphodiesterase type 4 inhibitor CHF6001 on virus-inducible cytokines, Pharmacology Research and Perspectives, Vol: 4, ISSN: 2052-1707

Respiratory virus infections precipitate asthma and chronic obstructive pulmonary disease (COPD) exacerbations, with most exacerbations due to rhinovirus infection. Both asthma and COPD exacerbations are not well controlled by steroid therapies, and there is a much research interest in finding improved therapies or combinations of therapies for controlling exacerbations. CHF6001 is a new, inhaled highly potent and selective phosphodiesterase type 4 (PDE4) inhibitor. Using in vitro human bronchial epithelial cells (BEAS-2B), we investigated the potential anti-inflammatory effects of CHF6001 on rhinovirus (RV1B)-induced cytokines. Cytokine mRNA was measured by real-time PCR, while protein release was measured by ELISA. CHF6001 was used in a 7-point dose–response curve (1000–0.001 nmol/L) as a 1.5-h pretreatment prior to infection in comparison with roflumilast. Both roflumilast and CHF6001 reduced RV1B-induced IL-8, IL-29, IP-10, and RANTES mRNA and protein in a concentration-dependent manner. Generally, CHF6001 was 13- to 16-fold more potent (subnanomolar EC50 values) than roflumilast at reducing IL-8, IL-29, IP-10, and RANTES mRNA and protein release, but had similar efficacies. In combination with the steroid fluticasone propionate (1 nmol/L), CHF6001 had additive effects, significantly reducing RV-induced cytokines when compared with steroid or CHF6001 alone. Combined low-dose steroid and low-dose CHF6001 had a similar efficacy as high-dose steroid or CHF6001 alone, indicating the combination had steroid and PDE4 inhibitor sparing effects. Overall results indicate that PDE4 inhibitors have anti-inflammatory activity against virus-induced inflammatory mediators and that CHF6001 is more potent than roflumilast.

JOURNAL ARTICLE

Russell KE, Chung KF, Clarke CJ, Durham AL, Mallia P, Footitt J, Johnston SL, Barnes PJ, Hall SR, Simpson KD, Starkey MR, Hansbro PM, Adcock IM, Wiegman CHet al., 2016, The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Lin L, Belgrave D, Bakhsoliani E, Hirsman A, Edwards MR, Walton RP, Solari R, Curtin JA, Simpson A, Rattray M, Custovic A, Johnston SLet al., 2016, Phenotyping Immune Responses In Asthma And Respiratory Infections, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Johnston SL, Szigeti M, Cross M, Brightling CE, Chaudhuri R, Harrison T, Mansur AH, Robinson L, Sattar Z, Jackson DJ, Mallia P, Wong EHC, Corrigan C, Higgins B, Ind P, Singh D, Thomson NC, Ashby D, Chauhan Aet al., 2016, A Randomised, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy Of Oral Azithromycin (500 Mg Od) As A Supplement To Standard Care For Adult Patients With Acute Exacerbations Of Asthma (the Azalea Trial), International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Footitt J, Mallia P, Durham AL, Ho WE, Trujillo-Torralbo M-B, Telcian AG, Del Rosario A, Chang C, Peh H-Y, Kebadze T, Aniscenko J, Stanciu L, Essilfie-Quaye S, Ito K, Barnes PJ, Elkin SL, Kon OM, Wong WSF, Adcock IM, Johnston SLet al., 2016, Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD, CHEST, Vol: 149, Pages: 62-73, ISSN: 0012-3692

JOURNAL ARTICLE

Hilzendeger C, da Silva J, Henket M, Schleich F, Corhay JL, Kebadze T, Edwards MR, Mallia P, Johnston SL, Louis Ret al., 2016, Reduced sputum expression of interferon-stimulated genes in severe COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 11, Pages: 1485-1493, ISSN: 1178-2005

JOURNAL ARTICLE

Jozwik A, Habibi MS, Paras A, Zhu J, Guvenel A, Dhariwal J, Almond M, Wong EHC, Sykes A, Maybeno M, Del Rosario J, Trujillo-Torralbo M-B, Mallia P, Sidney J, Peters B, Kon OM, Sette A, Johnston SL, Openshaw PJ, Chiu Cet al., 2015, RSV-specific airway resident memory CD8+T cells and differential disease severity after experimental human infection, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bachert C, Canonica GW, Casale T, Cruz AA, Demoly P, Hellings P, Valiulis A, Wickman M, Zuberbier T, Bosnic-Anticevitch S, Bedbrook A, Bergmann KC, Caimmi D, Dahl R, Fokkens WJ, Grisle I, Lodrup Carlsen K, Mullol J, Muraro A, Palkonen S, Papadopoulos N, Passalacqua G, Ryan D, Valovirta E, Yorgancioglu A, Aberer W, Agache I, Adachi M, Akdis CA, Akdis M, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Baiardini I, Baigenzhin AK, Barbara C, Bateman ED, Beghe B, Bel EH, Ben Kheder A, Bennoor KS, Benson M, Bewick M, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Boner AL, Boulet LP, Bonini M, Bonini S, Bosse I, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Calderon MA, Camargos PAM, Camuzat T, Carlsen KH, Carr W, Sarabia AMC, Chavannes NH, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Ciprandi G, Cirule I, Correia de Sousa J, Cox L, Crooks G, Costa DJ, Custovic A, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Wagner AF, Fletcher M, Fiocchi A, Forastiere F, Gamkrelidze A, Gemicioglu B, Gereda JE, Gonzalez Diaz S, Gotua M, Grouse L, Guzman MA, Haahtela T, Hellquist-Dahl B, Heinrich J, Horak F, Hourihane JOB, Howarth P, Humbert M, Hyland ME, Ivancevich JC, Jares EJ, Johnston SL, Joos G, Jonquet O, Jung KS, Just J, Kaidashev I, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Khaltaev N, Klimek L, N'Goran BK, Kolek V, Koppelman GH, Kowalski ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas-Linnemann D, Laune D, Le LTT, Lieberman P, Lipworth B, Li J, Louis R, Magard Y, Magnan A, Mahboub B, Majer I, Makela MJ, Manning P, De Manuel Keenoy E, Marshall GD, Masjedi MR, Maurer M, Mavale-Manuel S, Melen E, Melo-Gomes E, Meltzer EO, Merk H, Miculinic N, Mihaltan F, Milenket al., 2015, MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation, ALLERGY, Vol: 70, Pages: 1372-1392, ISSN: 0105-4538

JOURNAL ARTICLE

Carlsson CJ, Vissing NH, Sevelsted A, Johnston SL, Bonnelykke K, Bisgaard Het al., 2015, Duration of wheezy episodes in early childhood is independent of the microbial trigger, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 136, Pages: 1208-+, ISSN: 0091-6749

JOURNAL ARTICLE

Ritchie AI, Farne HA, Singanayagam A, Jackson DJ, Mallia P, Johnston SLet al., 2015, Pathogenesis of Viral Infection in Exacerbations of Airway Disease, ANNALS OF THE AMERICAN THORACIC SOCIETY, Vol: 12, Pages: S115-S132, ISSN: 1546-3222

JOURNAL ARTICLE

Eccles R, Winther B, Johnston SL, Robinson P, Trampisch M, Koelsch Set al., 2015, Efficacy and safety of iota-carrageenan nasal spray versus placebo in early treatment of the common cold in adults: the ICICC trial, RESPIRATORY RESEARCH, Vol: 16, ISSN: 1465-993X

JOURNAL ARTICLE

Dhariwal J, Kitson J, Jones RE, Nicholson G, Tunstall T, Walton RP, Francombe G, Gilbert J, Tan AJ, Murdoch R, Kon OM, Openshaw PJ, Hansel TTet al., 2015, Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Holt PG, Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N, Holt BJ, Hales B, Walker ML, Hollams EM, Bochkov YH, Grindle K, Johnston SL, Gern JE, Sly PD, Holt KE, Inouye Met al., 2015, Cohort-wide characterization of the nasopharyngeal microbiome across year 1 in "high risk" infants by PCR and 16S rRNA gene deep sequencing: elucidation of viral-bacterial-host interactions driving early atopic asthma pathogenesis, ALLERGY, Vol: 70, Pages: 111-112, ISSN: 0105-4538

JOURNAL ARTICLE

Hatchwell L, Collison A, Girkin J, Parsons K, Li J, Zhang J, Phipps S, Knight D, Bartlett NW, Johnston SL, Foster PS, Wark PAB, Mattes Jet al., 2015, Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia, THORAX, Vol: 70, Pages: 854-861, ISSN: 0040-6376

JOURNAL ARTICLE

Selroos O, Kupczyk M, Kuna P, Lacwik P, Bousquet J, Brennan D, Palkonen S, Contreras J, FitzGerald M, Hedlin G, Johnston SL, Louis R, Metcalf L, Walker S, Moreno-Galdo A, Papadopoulos NG, Rosado-Pinto J, Powell P, Haahtela Tet al., 2015, National and regional asthma programmes in Europe, EUROPEAN RESPIRATORY REVIEW, Vol: 24, Pages: 474-483, ISSN: 0905-9180

JOURNAL ARTICLE

Schoegler A, Stokes AB, Casaulta C, Regamey N, Edwards MR, Johnston SL, Jung A, Moeller A, Geiser T, Alves MPet al., 2015, Differential interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

Contoli M, Ito K, Padovani A, Poletti D, Marku B, Edwards MR, Stanciu LA, Gnesini G, Pastore A, Spanevello A, Morelli P, Johnston SL, Caramori G, Papi Aet al., 2015, Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells, ALLERGY, Vol: 70, Pages: 910-920, ISSN: 0105-4538

JOURNAL ARTICLE

Jackson DJ, Trujillo-Torralbo M-B, del-Rosario J, Bartlett NW, Edwards MR, Mallia P, Walton RP, Johnston SLet al., 2015, The influence of asthma control on the severity of virus-induced asthma exacerbations, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 136, Pages: 497-+, ISSN: 0091-6749

JOURNAL ARTICLE

Singanayagam A, Glanville N, Walton RP, Aniscenko J, Pearson RM, Pinkerton JW, Horvat JC, Hansbro PM, Bartlett NW, Johnston SLet al., 2015, A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD, CLINICAL SCIENCE, Vol: 129, Pages: 245-258, ISSN: 0143-5221

JOURNAL ARTICLE

Gielen V, Sykes A, Zhu J, Chan B, Macintyre J, Regamey N, Kieninger E, Gupta A, Shoemark A, Bossley C, Davies J, Saglani S, Walker P, Nicholson SE, Dalpke AH, Kon O-M, Bush A, Johnston SL, Edwards MRet al., 2015, Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 136, Pages: 177-U327, ISSN: 0091-6749

JOURNAL ARTICLE

Bonnelykke K, Vissing NH, Sevelsted A, Johnston SL, Bisgaard Het al., 2015, Association between respiratory infections in early life and later asthma is independent of virus type, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 136, Pages: 81-U164, ISSN: 0091-6749

JOURNAL ARTICLE

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