Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

527 results found

Niespodziana K, Cabauatan CR, Jackson DJ, Gallerano D, Trujillo-Torralbo B, del Rosario A, Mallia P, Valenta R, Johnston SLet al., 2015, Rhinovirus-induced VP1-specific Antibodies are Group-specific and Associated With Severity of Respiratory Symptoms, EBIOMEDICINE, Vol: 2, Pages: 64-70, ISSN: 2352-3964

JOURNAL ARTICLE

Almond MH, Bakhsoliani E, Edwards MR, Barclay WS, Johnston SLet al., 2015, Obesity Is Associated With Decreased Expression Of Suppressor Of Cytokine Signalling 3 In Human Alveolar Macrophages, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Calderazzo M, Trujillo-Torralbo M, Finney LJ, Kebadze T, Johnston SL, Mallia Pet al., 2015, Relationship Between Viral Colds And COPD Exacerbations, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Hilzendeger C, Da Silva J, Henket M, Moermans C, Corhay J-L, Edwards M, Johnston SL, Louis Ret al., 2015, Expression Of Interferons And Interferon-Stimulated Genes In Peripheral-Blood Neutrophils From COPD Patients, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Zdrenghea MT, Makrinioti H, Muresan A, Johnston SL, Stanciu LAet al., 2015, The role of macrophage IL-10/innate IFN interplay during virus-induced asthma, REVIEWS IN MEDICAL VIROLOGY, Vol: 25, Pages: 33-49, ISSN: 1052-9276

JOURNAL ARTICLE

Singanayagam A, Johnston SL, Mallia P, 2015, Inhaled Glucocorticoids and COPD Exacerbations, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 372, Pages: 92-93, ISSN: 0028-4793

JOURNAL ARTICLE

Toussaint M, Footitt J, Trujillo-Torralbo M-B, Kebadze T, Aniscenko J, Del Rosario A, Adcock IM, Johnston SL, Mallia Pet al., 2015, Airway Dna Levels In Virus-Induced COPD Exacerbations, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Bartlett NW, Singanayagam A, Johnston SL, 2015, Mouse models of rhinovirus infection and airways disease., Methods Mol Biol, Vol: 1221, Pages: 181-188

Mouse models are invaluable tools for gaining insight into host immunity during virus infection. Until recently, no practical mouse model for rhinovirus infection was available. Development of infection models was complicated by the existence of distinct groups of viruses that utilize different host cell surface proteins for binding and entry. Here, we describe mouse infection models, including virus purification and measurement of host immune responses, for representative viruses from two of these groups: (1) infection of unmodified Balb/c mice with minor group rhinovirus serotype 1B (RV-1B) and (2) infection of transgenic Balb/c mice with major group rhinovirus serotype 16 (RV-16).

JOURNAL ARTICLE

Jackson DJ, Makrinioti H, Rana BMJ, Shamji BWH, Trujillo-Torralbo M-B, Footitt J, Del-Rosario J, Telcian AG, Nikonova A, Zhu J, Aniscenko J, Gogsadze L, Bakhsoliani E, Traub S, Dhariwal J, Porter J, Hunt D, Hunt T, Hunt T, Stanciu LA, Khaitov M, Bartlett NW, Edwards MR, Kon OM, Mallia P, Papadopoulos NG, Akdis CA, Westwick J, Edwards MJ, Cousins DJ, Walton RP, Johnston SLet al., 2014, IL-33-Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 190, Pages: 1373-1382, ISSN: 1073-449X

JOURNAL ARTICLE

Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N, Holt B, Hales B, Walker M, Hollams E, Bochkov Y, Grindle K, Johnston S, Gern J, Sly P, Holt P, Holt K, Inouye Met al., 2014, The infant airway microbiome in health and disease impacts later asthma development

The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory illnesses (ARI). The development of asthma is initiated during infancy, driven by airway inflammation associated with infections. Here, we report viral and bacterial community profiling of NP aspirates across a birth cohort, capturing all lower respiratory illnesses during their first year. Most infants were initially colonized with Staphylococcus or Corynebacterium before stable colonization with Alloiococcus or Moraxella, with transient incursions of Streptococcus, Moraxella or Haemophilus marking virus-associated ARIs. Our data identify the NP microbiome as a determinant for infection spread to the lower airways, severity of accompanying inflammatory symptoms, and risk for future asthma development. Early asymptomatic colonization with Streptococcus was a strong asthma predictor, and antibiotic usage disrupted asymptomatic colonization patterns.

JOURNAL ARTICLE

Drysdale SB, Lo J, Prendergast M, Alcazar M, Wilson T, Zuckerman M, Smith M, Broughton S, Rafferty GF, Peacock JL, Johnston SL, Greenough Aet al., 2014, Lung function of preterm infants before and after viral infections, EUROPEAN JOURNAL OF PEDIATRICS, Vol: 173, Pages: 1497-1504, ISSN: 0340-6199

JOURNAL ARTICLE

Finney L, Berry M, Singanayagam A, Elkin SL, Johnston SL, Mallia Pet al., 2014, Inhaled corticosteroids and pneumonia in chronic obstructive pulmonary disease, LANCET RESPIRATORY MEDICINE, Vol: 2, Pages: 919-932, ISSN: 2213-2600

JOURNAL ARTICLE

Molyneaux PL, Cox MJ, Willis-Owen SAG, Mallia P, Russell KE, Russel A-M, Murphy E, Johnston SL, Schwarte DA, Wells AU, Cookson WOC, Maher TM, Moffatt MFet al., 2014, The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 190, Pages: 906-913, ISSN: 1073-449X

JOURNAL ARTICLE

Tsoumakidou M, Tousa S, Semitekolou M, Panagiotou P, Panagiotou A, Morianos I, Litsiou E, Trochoutsou AI, Konstantinou M, Potaris K, Footitt J, Mallia P, Zakynthinos S, Johnston SL, Xanthou Get al., 2014, Tolerogenic signaling by pulmonary CD1c(+) dendritic cells induces regulatory T cells in patients with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 134, Pages: 944-U282, ISSN: 0091-6749

JOURNAL ARTICLE

Beale J, Jayaraman A, Jackson DJ, Macintyre JDR, Edwards MR, Walton RP, Zhu J, Ching YM, Shamji B, Edwards M, Westwick J, Cousins DJ, Hwang YY, McKenzie A, Johnston SL, Bartlett NWet al., 2014, Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation, SCIENCE TRANSLATIONAL MEDICINE, Vol: 6, ISSN: 1946-6234

JOURNAL ARTICLE

Mousnier A, Swieboda D, Pinto A, Guedan A, Rogers AV, Walton R, Johnston SL, Solari Ret al., 2014, Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion, JOURNAL OF VIROLOGY, Vol: 88, Pages: 11671-11685, ISSN: 0022-538X

JOURNAL ARTICLE

Yang ZB, Wan XL, Yang WR, Jiang SZ, Zhang GG, Johnston SL, Chi Fet al., 2014, Effects of naturally mycotoxin-contaminated corn on nutrient and energy utilization of ducks fed diets with or without Calibrin-A, POULTRY SCIENCE, Vol: 93, Pages: 2199-2209, ISSN: 0032-5791

JOURNAL ARTICLE

Kupczyk M, Dahlen B, Sterk PJ, Nizankowska-Mogilnicka E, Papi A, Bel EH, Chanez P, Howarth PH, Holgate ST, Brusselle G, Siafakas NM, Gjomarkaj M, Dahlen S-Eet al., 2014, Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma, ALLERGY, Vol: 69, Pages: 1198-1204, ISSN: 0105-4538

JOURNAL ARTICLE

Nikonova A, Jackson D, Traub S, Johnston SL, Khaitov M, Stanciu LAet al., 2014, Changes in peripheral blood monocytes, B-cells, myeloid and plasmacytoid dendritic cells in asthma patients during rhinovirus-induced exacerbation, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 147-147, ISSN: 0105-4538

CONFERENCE PAPER

Lan F, Zhang N, Wang DX, Krysko O, Holtappels G, Papadopoulos NG, Johnston SL, Bachert Cet al., 2014, Staphyloccoccus aureus elicit epithelial cell-derived cytokine productions in human nasal tissue, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 169-169, ISSN: 0105-4538

CONFERENCE PAPER

Jayaraman A, Jackson DJ, Message SD, Pearson RM, Aniscenko J, Caramori G, Mallia P, Papi A, Shamji B, Edwards M, Westwick J, Hansel T, Stanciu LA, Johnston SL, Bartlett NWet al., 2014, IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection, Publisher: NATURE PUBLISHING GROUP

WORKING PAPER

Wolsk HM, Folsgaard N, Birch S, Brix S, Hansel TT, Johnston SL, Kebadze T, Chawes BL, Bonnelykke K, Bisgaard Het al., 2014, The presence of viruses alters the immune signature in the airway of asymptomatic neonates, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 192-193, ISSN: 0105-4538

CONFERENCE PAPER

Bousquet J, Addis A, Adcock I, Agache I, Agusti A, Alonso A, Annesi-Maesano I, Anto JM, Bachert C, Baena-Cagnani CE, Bai C, Baigenzhin A, Barbara C, Barnes PJ, Bateman ED, Beck L, Bedbrook A, Bel EH, Benezet O, Bennoor KS, Benson M, Bernabeu-Wittel M, Bewick M, Bindslev-Jensen C, Blain H, Blasi F, Bonini M, Bonini S, Boulet LP, Bourdin A, Bourret R, Bousquet PJ, Brightling CE, Briggs A, Brozek J, Buhl R, Bush A, Caimmi D, Calderon M, Calverley P, Camargos PA, Camuzat T, Canonica GW, Carlsen KH, Casale TB, Cazzola M, Sarabia AMC, Cesario A, Chen YZ, Chkhartishvili E, Chavannes NH, Chiron R, Chuchalin A, Chung KF, Cox L, Crooks G, Crooks MG, Cruz AA, Custovic A, Dahl R, Dahlen SE, De Blay F, Dedeu T, Deleanu D, Demoly P, Devillier P, Didier A, Dinh-Xuan AT, Djukanovic R, Dokic D, Douagui H, Dubakiene R, Eglin S, Elliot F, Emuzyte R, Fabbri L, Wagner AF, Fletcher M, Fokkens WJ, Fonseca J, Franco A, Frith P, Furber A, Gaga M, Garces J, Garcia-Aymerich J, Gamkrelidze A, Gonzales-Diaz S, Gouzi F, Guzman MA, Haahtela T, Harrison D, Hayot M, Heaney LG, Heinrich J, Hellings PW, Hooper J, Humbert M, Hyland M, Iaccarino G, Jakovenko D, Jardim JR, Jeandel C, Jenkins C, Johnston SL, Jonquet O, Joos G, Jung KS, Kalayci O, Karunanithi S, Keil T, Khaltaev N, Kolek V, Kowalski ML, Kull I, Kuna P, Kvedariene V, Le LT, Carlsen KCL, Louis R, MacNee W, Mair A, Majer I, Manning P, Keenoy EDM, Masjedi MR, Meten E, Melo-Gomes E, Menzies-Gow A, Mercier G, Mercier J, Michel JP, Miculinic N, Mihaltan F, Milenkovic B, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Morgan M, N'Diaye M, Nafti S, Nekam K, Neou A, Nicod L, O'Hehir R, Ohta K, Paggiaro P, Palkonen S, Palmer S, Papadopoulos NG, Papi A, Passalacqua G, Pavord I, Pigearias B, Plavec D, Postma DS, Price D, Rabe KF, Pontal FR, Redon J, Rennard S, Roberts J, Robine JM, Roca J, Roche N, Rodenas F, Roggeri A, Rolland C, Rosado-Pinto J, Ryan D, Samolinski B, Sanchez-Borges M, Schunemann HJ, Sheikh A, Shields M, Siafakas N, Sibilleet al., 2014, Integrated care pathways for airway diseases (AIRWAYS-ICPs), EUROPEAN RESPIRATORY JOURNAL, Vol: 44, Pages: 304-323, ISSN: 0903-1936

JOURNAL ARTICLE

Wong EHC, Porter JD, Edwards MR, Johnston SLet al., 2014, The role of macrolides in asthma: current evidence and future directions, LANCET RESPIRATORY MEDICINE, Vol: 2, Pages: 657-670, ISSN: 2213-2600

JOURNAL ARTICLE

Ic-Jusufagic AS, Belgrave D, Pickles A, Telcian AG, Bakhsoliani E, Sykes A, Simpson A, Johnston SL, Custovic Aet al., 2014, Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study, LANCET RESPIRATORY MEDICINE, Vol: 2, Pages: 621-630, ISSN: 2213-2600

JOURNAL ARTICLE

Djukanovic R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE, Marsden R, Boxall C, Dudley S, Plagnol V, Holgate ST, Monk Pet al., 2014, The Effect of Inhaled IFN-beta on Worsening of Asthma Symptoms Caused by Viral Infections A Randomized Trial, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 190, Pages: 145-154, ISSN: 1073-449X

JOURNAL ARTICLE

Rohde G, Message SD, Haas JJ, Kebadze T, Parker H, Laza-Stanca V, Khaitov MR, Kon OM, Stanciu LA, Mallia P, Edwards MR, Johnston SLet al., 2014, CXC chemokines and antimicrobial peptides in rhinovirus-induced experimental asthma exacerbations, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 44, Pages: 930-939, ISSN: 0954-7894

JOURNAL ARTICLE

Telcian AG, Zdrenghea MT, Caramori G, Laza-Stanca V, Message SD, Kebadze T, Kon OM, Groh V, Papi A, Johnston SL, Mallia P, Stanciu LAet al., 2014, Soluble Major Histocompatibility Complex Class I-Related Chain B Molecules Are Increased and Correlate With Clinical Outcomes During Rhinovirus Infection in Healthy Subjects, CHEST, Vol: 146, Pages: 32-40, ISSN: 0012-3692

JOURNAL ARTICLE

Drysdale SB, Prendergast M, Alcazar M, Wilson T, Smith M, Zuckerman M, Broughton S, Rafferty GF, Johnston SL, Hodemaekers HM, Janssen R, Bont L, Greenough Aet al., 2014, Genetic predisposition of RSV infection-related respiratory morbidity in preterm infants, EUROPEAN JOURNAL OF PEDIATRICS, Vol: 173, Pages: 905-912, ISSN: 0340-6199

JOURNAL ARTICLE

Khaitov MR, Shilovskiy IP, Nikonova AA, Shershakova NN, Kamyshnikov OY, Babakhin AA, Zverev VV, Johnston SL, Khaitov RMet al., 2014, Small Interfering RNAs Targeted to Interleukin-4 and Respiratory Syncytial Virus Reduce Airway Inflammation in a Mouse Model of Virus-Induced Asthma Exacerbation, HUMAN GENE THERAPY, Vol: 25, Pages: 642-650, ISSN: 1043-0342

JOURNAL ARTICLE

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