Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

527 results found

Drysdale SB, Alcazar M, Wilson T, Smith M, Zuckerman M, Lauinger IL, Tong CYW, Broughton S, Rafferty GF, Johnston SL, Greenough Aet al., 2014, Respiratory outcome of prematurely born infants following human rhinovirus A and C infections, EUROPEAN JOURNAL OF PEDIATRICS, Vol: 173, Pages: 913-919, ISSN: 0340-6199

JOURNAL ARTICLE

Suri R, Mallia P, Martin JE, Footitt J, Zhu J, Trujillo-Torralbo M-B, Johnston SL, Grigg Jet al., 2014, Bronchial platelet-activating factor receptor in chronic obstructive pulmonary disease, RESPIRATORY MEDICINE, Vol: 108, Pages: 898-904, ISSN: 0954-6111

JOURNAL ARTICLE

Zhu J, Message SD, Qiu Y, Mallia P, Kebadze T, Contoli M, Ward CK, Barnathan ES, Mascelli MA, Kon OM, Papi A, Stanciu LA, Jeffery PK, Johnston SLet al., 2014, Airway Inflammation and Illness Severity in Response to Experimental Rhinovirus Infection in Asthma, CHEST, Vol: 145, Pages: 1219-1229, ISSN: 0012-3692

JOURNAL ARTICLE

Hatchwell L, Girkin J, Dun MD, Morten M, Verrills N, Toop HD, Morris JC, Johnston SL, Foster PS, Collison A, Mattes Jet al., 2014, Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 133, Pages: 1720-1727, ISSN: 0091-6749

JOURNAL ARTICLE

Privolizzi R, Solari R, Johnston SL, McLean GRet al., 2014, The application of prophylactic antibodies for rhinovirus infections., Antivir Chem Chemother, Vol: 23, Pages: 173-177

Rhinoviruses are extremely common pathogens of the upper respiratory tract with adults experiencing on average 2-5 infections per year and children up to 12 infections. Although infections are not life threatening, except in cases of chronic lung disease where rhinoviruses are the major precipitant of acute exacerbations of disease, there is a high associated economic cost resulting from lost productivity due to absence from work or school. Treatment of infections focuses on symptom relief with anti-pyretics/analgesics as there are no antiviral therapies available and vaccine strategies face difficulties because of the large number of viral serotypes. Here, we assess the potential for prophylactic antibody intervention for these ubiquitous human pathogens.

JOURNAL ARTICLE

Reed DM, Foldes G, Gatheral T, Paschalaki KE, Lendvai Z, Bagyura Z, Nemeth T, Skopal J, Merkely B, Telcian AG, Gogsadze L, Edwards MR, Gough PJ, Bertin J, Johnston SL, Harding SE, Mitchell JAet al., 2014, Pathogen Sensing Pathways in Human Embryonic Stem Cell Derived-Endothelial Cells: Role of NOD1 Receptors, PLOS ONE, Vol: 9, ISSN: 1932-6203

JOURNAL ARTICLE

Adura PT, Reed E, Macintyre J, del Rosario A, Roberts J, Pestridge R, Beegan R, Boxall CB, Xiao C, Kebadze T, Aniscenko J, Cornelius V, Gern JE, Monk PD, Johnston SL, Djukanovic Ret al., 2014, Experimental rhinovirus 16 infection in moderate asthmatics on inhaled corticosteroids, EUROPEAN RESPIRATORY JOURNAL, Vol: 43, Pages: 1186-1189, ISSN: 0903-1936

JOURNAL ARTICLE

Makrinioti H, Toussaint M, Jackson DJ, Walton RP, Johnston SLet al., 2014, Role of interleukin 33 in respiratory allergy and asthma, LANCET RESPIRATORY MEDICINE, Vol: 2, Pages: 226-237, ISSN: 2213-2600

JOURNAL ARTICLE

Sykes A, Macintyre J, Edwards MR, del Rosario A, Haas J, Gielen V, Kon OM, McHale M, Johnston SLet al., 2014, Rhinovirus-induced interferon production is not deficient in well controlled asthma, THORAX, Vol: 69, Pages: 240-246, ISSN: 0040-6376

JOURNAL ARTICLE

Mahmutovic-Persson I, Akbarshahi H, Bartlett NW, Glanville N, Johnston SL, Brandelius A, Uller Let al., 2014, Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma, ALLERGY, Vol: 69, Pages: 348-358, ISSN: 0105-4538

JOURNAL ARTICLE

Molyneaux P, Cox M, Willis-Owen S, Russell K, Mallia P, Russell A-M, Johnston S, Wells A, Cookson W, Maher T, Moffatt Met al., 2014, High Bacterial Load Predicts Poor Outcomes in Patients with Idiopathic Pulmonary Fibrosis

Background: Repetitive alveolar damage and aberrant repair may be important in the development of the fatal condition Idiopathic Pulmonary Fibrosis (IPF). The role played by microorganisms in this cycle is unknown. Methods: We consecutively enrolled patients diagnosed with IPF according to international criteria together with healthy smokers, non-smokers and subjects with moderate Chronic Obstructive Pulmonary Disease (COPD) as controls. Subjects underwent bronchoalveolar lavage (BAL) from which genomic DNA was isolated. The V3-V5 region of the bacterial 16S rRNA gene was amplified, allowing quantification of bacterial load and identification of communities by 16S rRNA qPCR and pyrosequencing. Results: Our 65 IPF patients had 3.9x109 copies of the 16S rRNA gene per ml of BAL, two-fold more than the 1.8x109 copies in 44 sex- and smoking-matched controls (P<0.0001). Baseline BAL bacterial burden predicted Forced Vital Capacity (FVC) decline (P=0.02). Patients in the highest tertile of bacterial burden were at a higher risk of mortality compared to subjects in the lowest tertile (hazard ratio 4.59 (95% CI, 1.05-20); P=0.04). Sequencing yielded 912,883 high quality reads from all subjects. Operational Taxonomic Units (OTUs) representing Haemophilus, Streptococcus, Neisseria and Veillonella were 1.5 to 3.5 fold more abundant in cases than controls (P<0.05). Regression analyses indicated that these specific OTUs as well as bacterial burden associated independently with IPF. Conclusions: IPF is characterised by an increased bacterial burden in BAL that predicts decline in lung function and death. Clinical trials of antimicrobial therapy may determine if microbial burden is causal or not in IPF progression.

JOURNAL ARTICLE

Majoor CJ, de Pol MAV, Kamphuisen PW, Meijers JCM, Molenkamp R, Wolthers KC, van der Poll T, Nieuwland R, Johnston SL, Sterk PJ, Bel EHD, Lutter R, van der Sluijs KFet al., 2014, Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study, RESPIRATORY RESEARCH, Vol: 15, ISSN: 1465-993X

JOURNAL ARTICLE

Gunawardana N, Finney L, Johnston SL, Mallia Pet al., 2014, Experimental rhinovirus infection in COPD: Implications for antiviral therapies, ANTIVIRAL RESEARCH, Vol: 102, Pages: 95-105, ISSN: 0166-3542

JOURNAL ARTICLE

Kupczyk M, ten Brinke A, Sterk PJ, Bel EH, Papi A, Chanez P, Nizankowska-Mogilnicka E, Gjomarkaj M, Gaga M, Brusselle G, Dahlen B, Dahlen S-Eet al., 2014, Frequent exacerbators - a distinct phenotype of severe asthma, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 44, Pages: 212-221, ISSN: 0954-7894

JOURNAL ARTICLE

Jayaraman A, Bartlett N, Johnston SL, 2014, Innate and Adaptive Lymphocyte Responses In a Mouse Model Of Rhinovirus-Induced Asthma Exacerbation, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB135-AB135, ISSN: 0091-6749

CONFERENCE PAPER

Toussaint M, Singanayagam A, Johnston SL, Bartlett Net al., 2014, Role Of Interleukine-33 In Rhinovirus-Induced Allergic Asthma Exacerbation, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB52-AB52, ISSN: 0091-6749

CONFERENCE PAPER

Peel TJ, Jackson DJ, Johnston SL, Walton RPet al., 2014, Il-23, Increased In Asthmatics, Licences Il-17 Secretion In Response To Rhinovirus Infection, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X

JOURNAL ARTICLE

Mallia P, Message SD, Contoli M, Gray K, Telcian A, Laza-Stanca V, Papi A, Stanciu LA, Elkin S, Kon OM, Johnson M, Johnston SLet al., 2014, Lymphocyte subsets in experimental rhinovirus infection in chronic obstructive pulmonary disease, RESPIRATORY MEDICINE, Vol: 108, Pages: 78-85, ISSN: 0954-6111

JOURNAL ARTICLE

Jackson DJ, Shamji B, Trujillo-Torralbo M-B, Walton RP, Bartlett NW, Edwards MR, Mallia P, Edwards M, Westwick J, Johnston SLet al., 2014, Prostaglandin D2 Is Induced During Rhinovirus-Induced Asthma Exacerbations And Related To Exacerbation Severity In Vivo, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X

JOURNAL ARTICLE

Ching Y-M, Edwards MR, Glanville N, Johnston SL, Bartlett NWet al., 2014, Innate Type I Interferon Signalling Modulates Th2 Responses In Mouse Models Of Rhinovirus-Induced Airways Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X

JOURNAL ARTICLE

Stavrou A, Jolly L, Glanville N, Habgood A, Porte J, Tatler AL, Johnston SL, Blanchard A, Jenkins Get al., 2014, Influenza Infection, But Not Rhinovirus Infection, May Cause Exacerbation Of Lung Fibrosis Through Lung Collagen Deposition, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X

JOURNAL ARTICLE

Finney LJ, Ritchie A, Pollard E, Johnston SL, Mallia Pet al., 2014, Lower airway colonization and inflammatory response in COPD: a focus on Haemophilus influenzae, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 9, Pages: 1119-1132, ISSN: 1178-2005

JOURNAL ARTICLE

Majoor CJ, Van Der Pol MA, Kamphumen P, Meuers JCM, Van Der Poll T, Molenkamp R, Wolthers KC, Nieuwland R, Johnston SL, Sterk PJ, Bel E, Lulled R, Van Der Sluus KFet al., 2014, Hemostatic Activity Is Associated With Rhinovirus Load In Upper And Lower Airways In Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X

JOURNAL ARTICLE

Brignull LM, Czimmerer Z, Saidi H, Daniel B, Villela I, Bartlett NW, Johnston SL, Meira LB, Nagy L, Nohturfft Aet al., 2013, Reprogramming of lysosomal gene expression by interleukin-4 and Stat6, BMC GENOMICS, Vol: 14, ISSN: 1471-2164

JOURNAL ARTICLE

Footitt J, Mallia P, Durham A, Trujillo-Torralbo MB, Telcian A, Kebadze T, Aniscenko J, Essilfie-Quaye S, Ito K, Barnes PJ, Elkin S, Kon OM, Adcock I, Johnston SLet al., 2013, HDAC ACTIVITY IN MACROPHAGES IN EXPERIMENTAL RHINOVIRUS INFECTION IN COPD, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A58-A59, ISSN: 0040-6376

CONFERENCE PAPER

Molyneaux PL, Cox MJ, Mallia P, Johnston SL, Moffatt MF, Cookson WOC, Maher TMet al., 2013, THE ROLE OF THE RESPIRATORY MICROBIOME IN IDIOPATHIC PULMONARY FIBROSIS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A22-A22, ISSN: 0040-6376

CONFERENCE PAPER

Custovic A, Johnston SL, Pavord I, Gaga M, Fabbri L, Bel EH, Le Souef P, Lotvall J, Demoly P, Akdis CA, Ryan D, Makela MJ, Martinez F, Holloway JW, Saglani S, O'Byrne P, Papi A, Sergejeva S, Magnan A, Del Giacco S, Kalayci O, Hamelmann E, Papadopoulos NGet al., 2013, EAACI position statement on asthma exacerbations and severe asthma, ALLERGY, Vol: 68, Pages: 1520-1531, ISSN: 0105-4538

JOURNAL ARTICLE

van der Sluijs KF, van de Pol MA, Kulik W, Dijkhuis A, Smids BS, van Eijk HW, Karlas JA, Molenkamp R, Wolthers KC, Johnston SL, van der Zee JS, Sterk PJ, Lutter Ret al., 2013, Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design, THORAX, Vol: 68, Pages: 1122-1130, ISSN: 0040-6376

JOURNAL ARTICLE

Molyneaux PL, Mallia P, Cox MJ, Footitt J, Willis-Owen SAG, Homola D, Trujillo-Torralbo M-B, Elkin S, Kon OM, Cookson WOC, Moffatt MF, Johnston SLet al., 2013, Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 188, Pages: 1224-1231, ISSN: 1073-449X

JOURNAL ARTICLE

de Souza Alves CC, Collison A, Hatchwell L, Plank M, Morten M, Foster PS, Johnston SL, da Costa CF, de Almeida MV, Teixeira HC, Ferreira AP, Mattes Jet al., 2013, Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates T(H)2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation, PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

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