Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

471 results found

Molyneaux PL, Cox MJ, Mallia P, Johnston SL, Moffatt MF, Cookson WOC, Maher TMet al., 2013, THE ROLE OF THE RESPIRATORY MICROBIOME IN IDIOPATHIC PULMONARY FIBROSIS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A22-A22, ISSN: 0040-6376

CONFERENCE PAPER

Custovic A, Johnston SL, Pavord I, Gaga M, Fabbri L, Bel EH, Le Souef P, Lotvall J, Demoly P, Akdis CA, Ryan D, Makela MJ, Martinez F, Holloway JW, Saglani S, O'Byrne P, Papi A, Sergejeva S, Magnan A, Del Giacco S, Kalayci O, Hamelmann E, Papadopoulos NGet al., 2013, EAACI position statement on asthma exacerbations and severe asthma, ALLERGY, Vol: 68, Pages: 1520-1531, ISSN: 0105-4538

JOURNAL ARTICLE

van der Sluijs KF, van de Pol MA, Kulik W, Dijkhuis A, Smids BS, van Eijk HW, Karlas JA, Molenkamp R, Wolthers KC, Johnston SL, van der Zee JS, Sterk PJ, Lutter Ret al., 2013, Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design, THORAX, Vol: 68, Pages: 1122-1130, ISSN: 0040-6376

JOURNAL ARTICLE

Molyneaux PL, Mallia P, Cox MJ, Footitt J, Willis-Owen SAG, Homola D, Trujillo-Torralbo M-B, Elkin S, Kon OM, Cookson WOC, Moffatt MF, Johnston SLet al., 2013, Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 188, Pages: 1224-1231, ISSN: 1073-449X

JOURNAL ARTICLE

de Souza Alves CC, Collison A, Hatchwell L, Plank M, Morten M, Foster PS, Johnston SL, da Costa CF, de Almeida MV, Teixeira HC, Ferreira AP, Mattes Jet al., 2013, Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates T(H)2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation, PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

Glanville N, Message SD, Walton RP, Pearson RM, Parker HL, Laza-Stanca V, Mallia P, Kebadze T, Contoli M, Kon OM, Papi A, Stanciu LA, Johnston SL, Bartlett NWet al., 2013, gamma delta T cells suppress inflammation and disease during rhinovirus-induced asthma exacerbations, MUCOSAL IMMUNOLOGY, Vol: 6, Pages: 1091-1100, ISSN: 1933-0219

JOURNAL ARTICLE

Papi A, Contoli M, Adcock IM, Bellettato C, Padovani A, Casolari P, Stanciu LA, Barnes PJ, Johnston SL, Ito K, Caramori Get al., 2013, Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor kappa B and c-Jun N-terminal kinase activation, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 1075-+, ISSN: 0091-6749

JOURNAL ARTICLE

Drysdale SB, Alcazar-Paris M, Wilson T, Smith M, Zuckerman M, Broughton S, Rafferty GF, Peacock JL, Johnston SL, Greenough Aet al., 2013, Rhinovirus infection and healthcare utilisation in prematurely born infants, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, Pages: 1029-1036, ISSN: 0903-1936

JOURNAL ARTICLE

Porter JD, Macintyre J, Sykes A, Gupta A, Shoemark A, Bossley C, Davies J, Khaitov M, Moshkovskii S, Kon OM, Saglani S, Bush A, Johnston SL, Edwards MRet al., 2013, Azithromycin is able to augment interferon and interferon stimulated gene responses to rhinovirus in vitro, World Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization, Publisher: WILEY-BLACKWELL, Pages: 300-300, ISSN: 0105-4538

CONFERENCE PAPER

Khaitov M, Nikonova A, Jackson D, Traub S, Trujillo-Torralbo M-B, del Rosario A, Mallia P, Stanciu LA, Johnston SLet al., 2013, The role of M1 and M2 macrophages during rhinovirus-induced asthma exacerbation, World Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization, Publisher: WILEY-BLACKWELL, Pages: 56-56, ISSN: 0105-4538

CONFERENCE PAPER

Glanville N, Mclean GR, Guy B, Lecouturier V, Berry C, Girerd Y, Gregoire C, Walton RP, Pearson RM, Kebadze T, Burdin N, Bartlett NW, Almond JW, Johnston SLet al., 2013, Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein, PLOS PATHOGENS, Vol: 9, ISSN: 1553-7374

JOURNAL ARTICLE

Vareille M, Kieninger E, Alves MP, Kopf BS, Moeller A, Geiser T, Johnston SL, Edwards MR, Regamey Net al., 2013, Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells (Retraction of 67, 517, 2012), THORAX, Vol: 68, Pages: 886-886, ISSN: 0040-6376

JOURNAL ARTICLE

Traub S, Nikonova A, Carruthers A, Dunmore R, Vousden KA, Gogsadze L, Hao W, Zhu Q, Bernard K, Zhu J, Dymond M, McLean GR, Walton RP, Glanville N, Humbles A, Khaitov M, Wells T, Kolbeck R, Leishman AJ, Sleeman MA, Bartlett NW, Johnston SLet al., 2013, An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation, PLOS PATHOGENS, Vol: 9, ISSN: 1553-7366

JOURNAL ARTICLE

Mallia P, Message SD, Contoli M, Gray KK, Telcian A, Laza-Stanca V, Papi A, Stanciu LA, Elkin S, Kon OM, Johnson M, Johnston SLet al., 2013, Neutrophil adhesion molecules in experimental rhinovirus infection in COPD, RESPIRATORY RESEARCH, Vol: 14, ISSN: 1465-993X

JOURNAL ARTICLE

Almond MH, Edwards MR, Barclay WS, Johnston SLet al., 2013, Obesity and susceptibility to severe outcomes following respiratory viral infection, THORAX, Vol: 68, Pages: 684-686, ISSN: 0040-6376

JOURNAL ARTICLE

Edwards MR, Regamey N, Vareille M, Kieninger E, Gupta A, Shoemark A, Saglani S, Sykes A, Macintyre J, Davies J, Bossley C, Bush A, Johnston SLet al., 2013, Impaired innate interferon induction in severe therapy resistant atopic asthmatic children, MUCOSAL IMMUNOLOGY, Vol: 6, Pages: 797-806, ISSN: 1933-0219

JOURNAL ARTICLE

Kupczyk M, Haque S, Sterk PJ, Nizankowska-Mogilnicka E, Papi A, Bel EH, Chanez P, Dahlen B, Gaga M, Gjomarkaj M, Howarth PH, Johnston SL, Joos GF, Kanniess F, Tzortzaki E, James A, Middelveld RJM, Dahlen S-Eet al., 2013, Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study, THORAX, Vol: 68, Pages: 611-618, ISSN: 0040-6376

JOURNAL ARTICLE

Majoor CJ, Kamphuisen PW, Van de Pol MA, Meijers JC, Van der Poll T, Nieuwland R, Johnston SL, Bel EH, Lutter R, Van der Sluijs KFet al., 2013, Rhinovirus infection induces procoagulant changes in parallel with eosinophilic airway inflammation, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 11, Pages: 742-742, ISSN: 1538-7933

JOURNAL ARTICLE

Sykes A, Edwards MR, Macintyre J, del Rosario A, Gielen V, Haas J, Kon OM, McHale M, Johnston SLet al., 2013, TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma, PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

, 2013, Virus-bacteria interactions in COPD exacerbations, European Respiratory Monograph, Vol: 60, Pages: 76-83, ISSN: 1025-448X

Chronic obstructive pulmonary disease (COPD) is a disease characterised by acute exacerbations. Respiratory infections, including viruses and bacteria, are common aetiological agents and some studies have detected dual viral- bacterial infection during exacerbations. However, the mechanisms underlying virus-bacteria interactions in COPD are poorly characterised. In vitro studies have shown that viral infection can increase susceptibility to secondary bacterial infection, and animal models of sequential infection have revealed potential molecular mechanisms of how viral infection may impact upon subsequent secondary bacterial infection. A recently reported human experimental rhinovirus infection model of COPD exacerbation has provided additional evidence that viral- bacterial co-infection may be more common in COPD exacerbations than previously thought. Further understanding of the mechanisms involved in virus-bacteria interactions may facilitate development of novel therapies with the potential to reduce or prevent secondary bacterial infections following respiratory viral exacerbations in COPD. In this chapter, the evidence for dual viral and bacterial infection in COPD exacerbations is outlined, and existing evidence for underlying mechanistic interactions is discussed. © ERS 2013.

JOURNAL ARTICLE

Dhariwal J, Edwards MR, Johnston SL, 2013, Anti-viral agents: potential utility in exacerbations of asthma, CURRENT OPINION IN PHARMACOLOGY, Vol: 13, Pages: 331-336, ISSN: 1471-4892

JOURNAL ARTICLE

Foster PS, Plank M, Collison A, Tay HL, Kaiko GE, Li J, Johnston SL, Hansbro PM, Kumar RK, Yang M, Mattes Jet al., 2013, The emerging role of microRNAs in regulating immune and inflammatory responses in the lung, IMMUNOLOGICAL REVIEWS, Vol: 253, Pages: 198-215, ISSN: 0105-2896

JOURNAL ARTICLE

Girkin J, Hatchwell L, Foster PS, Johnston SL, Collison A, Mattes Jet al., 2013, SALMETEROL ATTENUATES CHEMOTAXIS IN RHINOVIRUS-INDUCED EXACERBATION OF ASTHMA VIA MODULATION OF PP2A, RESPIROLOGY, Vol: 18, Pages: 13-13, ISSN: 1323-7799

JOURNAL ARTICLE

Hatchwell L, Collison A, Phipps S, Foster PS, Johnston SL, Mattes Jet al., 2013, CCL7 (MCP-3) MEDIATES RHINOVIRUS-INDUCED LUNG INFLAMMATION AND EXACERBATION OF ALLERGIC AIRWAY DISEASE, RESPIROLOGY, Vol: 18, Pages: 40-40, ISSN: 1323-7799

JOURNAL ARTICLE

Bardin PG, Johnston SL, Hamilton G, 2013, Middle airway obstruction-it may be happening under our noses, THORAX, Vol: 68, Pages: 396-398, ISSN: 0040-6376

JOURNAL ARTICLE

Hansel TT, Johnston SL, Openshaw PJ, 2013, Microbes and mucosal immune responses in asthma, LANCET, Vol: 381, Pages: 861-873, ISSN: 0140-6736

JOURNAL ARTICLE

McLean GR, Walton RP, Shetty S, Peel TJ, Paktiawal N, Kebadze T, Gogsadze L, Niespodziana K, Valenta R, Bartlett NW, Johnston SLet al., 2013, Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1 (vol 95, pg 193, 2012), ANTIVIRAL RESEARCH, Vol: 97, Pages: 381-381, ISSN: 0166-3542

JOURNAL ARTICLE

Burney PG, Johnston SL, Warner JO, 2013, Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs (vol 130, pg 1049, 2012), JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 131, Pages: 618-618, ISSN: 0091-6749

JOURNAL ARTICLE

Collison A, Hatchwell L, Verrills N, Wark PAB, de Siqueira AP, Tooze M, Carpenter H, Don AS, Morris JC, Zimmermann N, Bartlett NW, Rothenberg ME, Johnston SL, Foster PS, Mattes Jet al., 2013, The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity, NATURE MEDICINE, Vol: 19, Pages: 232-237, ISSN: 1078-8956

JOURNAL ARTICLE

Qiu YS, Zhu J, Footitt JI, Trujillo-Torralbo M-B, Message SD, Kebadze T, Aniscenko J, Ito K, Barnes PJ, Adcock IM, Kon OM, Elkin SL, Johnson M, Contoli M, Papi A, Stanciu LA, Mallia P, Jeffery PK, Johnston SLet al., 2013, Histone Deacetylase-2 Expression In Bronchial Mucosa Of Experimental Rhinovirus-Induced Exacerbations Of COPD, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

JOURNAL ARTICLE

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