Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

546 results found

Hansel TT, Johnston SL, Openshaw PJ, 2013, Microbes and mucosal immune responses in asthma, LANCET, Vol: 381, Pages: 861-873, ISSN: 0140-6736

Journal article

McLean GR, Walton RP, Shetty S, Peel TJ, Paktiawal N, Kebadze T, Gogsadze L, Niespodziana K, Valenta R, Bartlett NW, Johnston SLet al., 2013, Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1 (vol 95, pg 193, 2012), ANTIVIRAL RESEARCH, Vol: 97, Pages: 381-381, ISSN: 0166-3542

Journal article

Collison A, Hatchwell L, Verrills N, Wark PAB, de Siqueira AP, Tooze M, Carpenter H, Don AS, Morris JC, Zimmermann N, Bartlett NW, Rothenberg ME, Johnston SL, Foster PS, Mattes Jet al., 2013, The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity, NATURE MEDICINE, Vol: 19, Pages: 232-237, ISSN: 1078-8956

Journal article

Burney PG, Johnston SL, Warner JO, 2013, Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs (vol 130, pg 1049, 2012), JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 131, Pages: 618-618, ISSN: 0091-6749

Journal article

Reinius LE, Gref A, Saaf A, Acevedo N, Joerink M, Kupczyk M, D'Amato M, Bergstroem A, Melen E, Scheynius A, Dahlen S-E, Pershagen G, Soderhall C, Kere Jet al., 2013, DNA Methylation in the Neuropeptide S Receptor 1 (NPSR1) Promoter in Relation to Asthma and Environmental Factors, PLOS ONE, Vol: 8, ISSN: 1932-6203

Journal article

Mallia P, Footitt J, Trujillo-Torralbo M-B, Kebadze T, Ho EW, Cheng C, Yong PH, Wong W, Ito K, Adcock IM, Barnes PJ, Elkin S, Kon O, Johnston SLet al., 2013, Oxidative Stress In Experimental Rhinovirus Infections In COPD, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

Journal article

Jackson DJ, Trujillo-Torralbo M-B, Shamji B, Footitt J, Del-Rosario J, Telcian A, Nikonova A, Bartlett NW, Walton RP, Edwards MR, Kon O-M, Mallia P, Edwards M, Westwick J, Hansel T, Johnston SLet al., 2013, Sampling Airway Mucosal Lining Fluid Identifies Roles For Il-33 And Multiple Inflammatory Pathways In Virus-Induced Asthma Exacerbations, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

Journal article

Qiu YS, Zhu J, Footitt JI, Trujillo-Torralbo M-B, Message SD, Kebadze T, Aniscenko J, Ito K, Barnes PJ, Adcock IM, Kon OM, Elkin SL, Johnson M, Contoli M, Papi A, Stanciu LA, Mallia P, Jeffery PK, Johnston SLet al., 2013, Histone Deacetylase-2 Expression In Bronchial Mucosa Of Experimental Rhinovirus-Induced Exacerbations Of COPD, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

Journal article

Zhu J, Footitt JI, Qiu YS, Message SD, Kebadze T, Aniscenko J, Ito K, Barnes PJ, Adcock IM, Kon OM, Johnson M, Contoli M, Papi A, Stanciu LA, Jeffery PK, Mallia P, Johnston SLet al., 2013, Bronchial Mucosal Inflammatory Responses In Rhinovirus Induced Exacerbations Of Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

Journal article

Walton RP, Bartlett NW, Quint DJ, Stanciu L, Johnston SLet al., 2013, Respiratory Viral Infection Reverses Dendritic Cell Mediated Immunological Tolerance, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

Journal article

Sykes A, Edwards MR, Macintyre J, del Rosario A, Kon OM, Johnston SLet al., 2012, ROLES OF TLR3, TLR4-AND TLRS7-9 IN INTERFERON INDUCTION IN BRONCHIAL EPITHELIAL CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS FROM ASTHMATIC AND NON-ASTHMATIC SUBJECTS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A58-A58, ISSN: 0040-6376

Conference paper

Mallia P, Footitt J, Sotero R, Jepson A, Contoli M, Trujillo-Torralbo M-B, Kebadze T, Aniscenko J, Oleszkiewicz G, Gray K, Message SD, Ito K, Barnes PJ, Adcock IM, Papi A, Stanciu LA, Elkin SL, Kon OM, Johnson M, Johnston SLet al., 2012, Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 1117-1124, ISSN: 1073-449X

Journal article

Jackson DJ, Trujillo-Torralbo M, Footitt J, Shamji B, del-Rosario J, Telcian A, Hunt T, Hunt D, Mallia P, Kon OM, Edwards M, Westwick J, Hansel TT, Johnston SLet al., 2012, SAMPLING AIRWAY MUCOSAL LINING FLUID IDENTIFIES ROLES FOR IL-33 AND MULTIPLE INFLAMMATORY PATHWAYS IN VIRUS-INDUCED ASTHMA EXACERBATIONS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A3-A3, ISSN: 0040-6376

Conference paper

Jackson DJ, Trujillo-Torralbo M, del-Rosario J, Footitt J, Mallia P, Kon OM, Hansel TT, Johnston SLet al., 2012, BASELINE ASTHMA CONTROL AND SEVERITY INFLUENCES THE OUTCOME OF VIRUS-INDUCED ASTHMA EXACERBATIONS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A32-A32, ISSN: 0040-6376

Conference paper

Bartlett NW, Slater L, Glanville N, Haas JJ, Caramori G, Casolari P, Clarke DL, Message SD, Aniscenko J, Kebadze T, Zhu J, Mallia P, Mizgerd JP, Belvisi M, Papi A, Kotenko SV, Johnston SL, Edwards MRet al., 2012, Defining critical roles for NF-?B p65 and type I interferon in innate immunity to rhinovirus, EMBO MOLECULAR MEDICINE, Vol: 4, Pages: 1244-1260, ISSN: 1757-4676

Journal article

Bousquet J, Schuenemann HJ, Samolinski B, Demoly P, Baena-Cagnani CE, Bachert C, Bonini S, Boulet LP, Bousquet PJ, Brozek JL, Canonica GW, Casale TB, Cruz AA, Fokkens WJ, Fonseca JA, van Wijk RG, Grouse L, Haahtela T, Khaltaev N, Kuna P, Lockey RF, Carlsen KCL, Mullol J, Naclerio R, O'Hehir RE, Ohta K, Palkonen S, Papadopoulos NG, Passalacqua G, Pawankar R, Price D, Ryan D, Simons FER, Togias A, Williams D, Yorgancioglu A, Yusuf OM, Aberer W, Adachi M, Agache I, Ait-Khaled N, Akdis CA, Andrianarisoa A, Annesi-Maesano I, Ansotegui IJ, Baiardini I, Bateman ED, Bedbrook A, Beghe B, Beji M, Bel EH, Ben Kheder A, Bennoor KS, Bergmann KC, Berrissoul F, Bieber T, Jensen CB, Blaiss MS, Boner AL, Bouchard J, Braido F, Brightling CE, Bush A, Caballero F, Calderon MA, Calvo MA, Camargos PAM, Caraballo LR, Carlsen KH, Carr W, Cepeda AM, Cesario A, Chavannes NH, Chen YZ, Chiriac AM, Chivato Perez T, Chkhartishvili E, Ciprandi G, Costa DJ, Cox L, Custovic A, Dahl R, Darsow U, De Blay F, Deleanu D, Denburg JA, Devillier P, Didi T, Dokic D, Dolen WK, Douagui H, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, El-Meziane A, Emuzyte R, Fiocchi A, Fletcher M, Fukuda T, Gamkrelidze A, Gereda JE, Gonzalez Diaz S, Gotua M, Guzman MA, Hellings PW, Hellquist-Dahl B, Horak F, Hourihane JO, Howarth P, Humbert M, Ivancevich JC, Jackson C, Just J, Kalayci O, Kaliner MA, Kalyoncu AF, Keil T, Keith PK, Khayat G, Kim YY, N'Goran BK, Koppelman GH, Kowalski ML, Kull I, Kvedariene V, Larenas-Linnemann D, Le LT, Lemiere C, Li J, Lieberman P, Lipworth B, Mahboub B, Makela MJ, Martin F, Marshall GD, Martinez FD, Masjedi MR, Maurer M, Mavale-Manuel S, Mazon A, Melen E, Meltzer EO, Mendez NH, Merk H, Mihaltan F, Mohammad Y, Morais-Almeida M, Muraro A, Nafti S, Namazova-Baranova L, Nekam K, Neou A, Niggemann B, Nizankowska-Mogilnicka E, Nyembue TD, Okamoto Y, Okubo K, Orru MP, Ouedraogo S, Ozdemir C, Panzner P, Pali-Schoell I, Park HS, Pigearias B, Pohl W, Popov TA, Postma DS, Potter P, Rabe KF, Ratomaharet al., 2012, Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 130, Pages: 1049-1062, ISSN: 0091-6749

Journal article

McLean GR, Walton RP, Shetty S, Paktiawal N, Kebadze T, Gogsadze L, Niespodziana K, Valenta R, Bartlett NW, Johnston SLet al., 2012, Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1, ANTIVIRAL RESEARCH, Vol: 95, Pages: 193-201, ISSN: 0166-3542

Journal article

Zdrenghea MT, Mallia P, Johnston SL, 2012, Immunological pathways in virus-induced COPD exacerbations: a role for IL-15, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 42, Pages: 1010-1015, ISSN: 0014-2972

Journal article

Caramori G, Papadopoulos N, Contoli M, Marku B, Forini G, Pauletti A, Johnston SL, Papi Aet al., 2012, Asthma: A Chronic Infectious Disease?, CLINICS IN CHEST MEDICINE, Vol: 33, Pages: 473-+, ISSN: 0272-5231

Journal article

Beasley V, Joshi P, Singanayagam AS, Molyneaux PL, Johnston SL, Mallia Pet al., 2012, Lung microbiology and exacerbations in COPD, International Journal of Chronic Obstructive Pulmonary Disease, Vol: 2012, Pages: 555-569, ISSN: 1176-9106

Chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory condition in adults and is characterized by progressive airflow limitation that is not fully reversible. The main etiological agents linked with COPD are cigarette smoking and biomass exposure but respiratory infection is believed to play a major role in the pathogenesis of both stable COPD and in acute exacerbations. Acute exacerbations are associated with more rapid decline in lung function and impaired quality of life and are the major causes of morbidity and mortality in COPD. Preventing exacerbations is a major therapeutic goal but currently available treatments for exacerbations are not very effective. Historically, bacteria were considered the main infective cause of exacerbations but with the development of new diagnostic techniques, respiratory viruses are also frequently detected in COPD exacerbations. This article aims to provide a state-of-the art review of current knowledge regarding the role of infection in COPD, highlight the areas of ongoing debate and controversy, and outline emerging technologies and therapies that will influence future diagnostic and therapeutic pathways in COPD.

Journal article

Skevaki CL, Psarras S, Volonaki E, Pratsinis H, Spyridaki IS, Gaga M, Georgiou V, Vittorakis S, Telcian AG, Maggina P, Kletsas D, Gourgiotis D, Johnston SL, Papadopoulos NGet al., 2012, Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features., Clin Transl Allergy, Vol: 2

UNLABELLED: BACKGROUND: Human rhinoviruses, major precipitants of asthma exacerbations, induce lower airway inflammation and mediate angiogenesis. The purpose of this study was to assess the possibility that rhinoviruses may also contribute to the fibrotic component of airway remodeling. METHODS: Levels of basic fibroblast growth factor (bFGF) mRNA and protein were measured following rhinovirus infection of bronchial epithelial cells. The profibrotic effect of epithelial products was assessed by DNA synthesis and matrix metalloproteinase activity assays. Moreover, epithelial cells were exposed to supernatants from cultured peripheral blood mononuclear cells, obtained from healthy donors or atopic asthmatic subjects and subsequently infected by rhinovirus and bFGF release was estimated. bFGF was also measured in respiratory secretions from atopic asthmatic patients before and during rhinovirus-induced asthma exacerbations. RESULTS: Rhinovirus epithelial infection stimulated mRNA expression and release of bFGF, the latter being positively correlated with cell death under conditions promoting rhinovirus-induced cytotoxicity. Supernatants from infected cultures induced lung fibroblast proliferation, which was inhibited by anti-bFGF antibody, and demonstrated increased matrix metalloproteinase activity. Rhinovirus-mediated bFGF release was significantly higher in an in vitro simulation of atopic asthmatic environment and, importantly, during rhinovirus-associated asthma exacerbations. CONCLUSIONS: Rhinovirus infection induces bFGF release by airway epithelium, and stimulates stroma cell proliferation contributing to airway remodeling in asthma. Repeated rhinovirus infections may promote asthma persistence, particularly in the context of atopy; prevention of such infections may influence the natural history of asthma.

Journal article

Johnston SL, Voordouw G, 2012, Sulfate-Reducing Bacteria Lower Sulfur-Mediated Pitting Corrosion under Conditions of Oxygen Ingress, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 46, Pages: 9183-9190, ISSN: 0013-936X

Journal article

Chawes BLK, Poorisrisak P, Johnston SL, Bisgaard Het al., 2012, Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 130, Pages: 354-+, ISSN: 0091-6749

Journal article

Gibson CR, Mader TH, Schallhorn SC, Pesudovs K, Lipsky W, Raid E, Jennings RT, Fogarty JA, Garriott RA, Garriott OK, Johnston SLet al., 2012, Visual stability of laser vision correction in an astronaut on a Soyuz mission to the International Space Station, JOURNAL OF CATARACT AND REFRACTIVE SURGERY, Vol: 38, Pages: 1486-1491, ISSN: 0886-3350

Journal article

Edwards MR, Bartlett NW, Hussell T, Openshaw P, Johnston SLet al., 2012, The microbiology of asthma, NATURE REVIEWS MICROBIOLOGY, Vol: 10, Pages: 459-471, ISSN: 1740-1526

Journal article

Bafadhel M, McKenna S, Terry S, Mistry V, Pancholi M, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CEet al., 2012, Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease A Randomized Placebo-Controlled Trial, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 48-55, ISSN: 1073-449X

Journal article

Sykes A, Edwards MR, Macintyre J, del Rosario A, Bakhsoliani E, Trujillo-Torralbo M-B, Kon OM, Mallia P, McHale M, Johnston SLet al., 2012, Rhinovirus 16-induced IFN-alpha and IFN-beta are deficient in bronchoalveolar lavage cells in asthmatic patients, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 129, Pages: 1506-+, ISSN: 0091-6749

Journal article

Zdrenghea MT, Johnston SL, 2012, Role of PD-L1/PD-1 in the immune response to respiratory viral infections, MICROBES AND INFECTION, Vol: 14, Pages: 495-499, ISSN: 1286-4579

Journal article

Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators, MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam Pet al., 2012, IFITM3 restricts the morbidity and mortality associated with influenza., Nature, Vol: 484, Pages: 519-523

The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population. Recent in vitro studies show that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses1, 2, 3, 4, 5, 6, 7. Both the magnitude and breadth of the IFITM proteins’ in vitro effects suggest that they are critical for intrinsic resistance to such viruses, including influenza viruses. Using a knockout mouse model8, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo. Mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 ‘Spanish’ influenza9, 10. Similar increased viral replication is seen in vitro, with protection rescued by the re-introduction of Ifitm3. To test the role of IFITM3 in human influenza virus infection, we assessed the IFITM3 alleles of individuals hospitalized with seasonal or pandemic influenza H1N1/09 viruses. We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro. Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.

Journal article

Slater L, Bartlett NW, Haas JJ, Zhu J, Message SD, Walton RP, Sykes A, Dahdaleh S, Clarke DL, Belvisi MG, Kon OM, Fujita T, Jeffery PK, Johnston SL, Edwards MRet al., 2012, Correction: Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium, PLoS Pathogens, Vol: 8

Journal article

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