Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

527 results found

Mallia P, Footitt J, Sotero R, Jepson A, Contoli M, Trujillo-Torralbo M-B, Kebadze T, Aniscenko J, Oleszkiewicz G, Gray K, Message SD, Ito K, Barnes PJ, Adcock IM, Papi A, Stanciu LA, Elkin SL, Kon OM, Johnson M, Johnston SLet al., 2012, Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 1117-1124, ISSN: 1073-449X

JOURNAL ARTICLE

Bartlett NW, Slater L, Glanville N, Haas JJ, Caramori G, Casolari P, Clarke DL, Message SD, Aniscenko J, Kebadze T, Zhu J, Mallia P, Mizgerd JP, Belvisi M, Papi A, Kotenko SV, Johnston SL, Edwards MRet al., 2012, Defining critical roles for NF-?B p65 and type I interferon in innate immunity to rhinovirus, EMBO MOLECULAR MEDICINE, Vol: 4, Pages: 1244-1260, ISSN: 1757-4676

JOURNAL ARTICLE

Jackson DJ, Trujillo-Torralbo M, del-Rosario J, Footitt J, Mallia P, Kon OM, Hansel TT, Johnston SLet al., 2012, BASELINE ASTHMA CONTROL AND SEVERITY INFLUENCES THE OUTCOME OF VIRUS-INDUCED ASTHMA EXACERBATIONS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A32-A32, ISSN: 0040-6376

CONFERENCE PAPER

Jackson DJ, Trujillo-Torralbo M, Footitt J, Shamji B, del-Rosario J, Telcian A, Hunt T, Hunt D, Mallia P, Kon OM, Edwards M, Westwick J, Hansel TT, Johnston SLet al., 2012, SAMPLING AIRWAY MUCOSAL LINING FLUID IDENTIFIES ROLES FOR IL-33 AND MULTIPLE INFLAMMATORY PATHWAYS IN VIRUS-INDUCED ASTHMA EXACERBATIONS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A3-A3, ISSN: 0040-6376

CONFERENCE PAPER

Sykes A, Edwards MR, Macintyre J, del Rosario A, Kon OM, Johnston SLet al., 2012, ROLES OF TLR3, TLR4-AND TLRS7-9 IN INTERFERON INDUCTION IN BRONCHIAL EPITHELIAL CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS FROM ASTHMATIC AND NON-ASTHMATIC SUBJECTS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A58-A58, ISSN: 0040-6376

CONFERENCE PAPER

Bousquet J, Schuenemann HJ, Samolinski B, Demoly P, Baena-Cagnani CE, Bachert C, Bonini S, Boulet LP, Bousquet PJ, Brozek JL, Canonica GW, Casale TB, Cruz AA, Fokkens WJ, Fonseca JA, van Wijk RG, Grouse L, Haahtela T, Khaltaev N, Kuna P, Lockey RF, Carlsen KCL, Mullol J, Naclerio R, O'Hehir RE, Ohta K, Palkonen S, Papadopoulos NG, Passalacqua G, Pawankar R, Price D, Ryan D, Simons FER, Togias A, Williams D, Yorgancioglu A, Yusuf OM, Aberer W, Adachi M, Agache I, Ait-Khaled N, Akdis CA, Andrianarisoa A, Annesi-Maesano I, Ansotegui IJ, Baiardini I, Bateman ED, Bedbrook A, Beghe B, Beji M, Bel EH, Ben Kheder A, Bennoor KS, Bergmann KC, Berrissoul F, Bieber T, Jensen CB, Blaiss MS, Boner AL, Bouchard J, Braido F, Brightling CE, Bush A, Caballero F, Calderon MA, Calvo MA, Camargos PAM, Caraballo LR, Carlsen KH, Carr W, Cepeda AM, Cesario A, Chavannes NH, Chen YZ, Chiriac AM, Chivato Perez T, Chkhartishvili E, Ciprandi G, Costa DJ, Cox L, Custovic A, Dahl R, Darsow U, De Blay F, Deleanu D, Denburg JA, Devillier P, Didi T, Dokic D, Dolen WK, Douagui H, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, El-Meziane A, Emuzyte R, Fiocchi A, Fletcher M, Fukuda T, Gamkrelidze A, Gereda JE, Gonzalez Diaz S, Gotua M, Guzman MA, Hellings PW, Hellquist-Dahl B, Horak F, Hourihane JO, Howarth P, Humbert M, Ivancevich JC, Jackson C, Just J, Kalayci O, Kaliner MA, Kalyoncu AF, Keil T, Keith PK, Khayat G, Kim YY, N'Goran BK, Koppelman GH, Kowalski ML, Kull I, Kvedariene V, Larenas-Linnemann D, Le LT, Lemiere C, Li J, Lieberman P, Lipworth B, Mahboub B, Makela MJ, Martin F, Marshall GD, Martinez FD, Masjedi MR, Maurer M, Mavale-Manuel S, Mazon A, Melen E, Meltzer EO, Mendez NH, Merk H, Mihaltan F, Mohammad Y, Morais-Almeida M, Muraro A, Nafti S, Namazova-Baranova L, Nekam K, Neou A, Niggemann B, Nizankowska-Mogilnicka E, Nyembue TD, Okamoto Y, Okubo K, Orru MP, Ouedraogo S, Ozdemir C, Panzner P, Pali-Schoell I, Park HS, Pigearias B, Pohl W, Popov TA, Postma DS, Potter P, Rabe KF, Ratomaharet al., 2012, Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 130, Pages: 1049-1062, ISSN: 0091-6749

JOURNAL ARTICLE

Caramori G, Papadopoulos N, Contoli M, Marku B, Forini G, Pauletti A, Johnston SL, Papi Aet al., 2012, Asthma: A Chronic Infectious Disease?, CLINICS IN CHEST MEDICINE, Vol: 33, Pages: 473-+, ISSN: 0272-5231

JOURNAL ARTICLE

Zdrenghea MT, Mallia P, Johnston SL, 2012, Immunological pathways in virus-induced COPD exacerbations: a role for IL-15, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 42, Pages: 1010-1015, ISSN: 0014-2972

JOURNAL ARTICLE

McLean GR, Walton RP, Shetty S, Paktiawal N, Kebadze T, Gogsadze L, Niespodziana K, Valenta R, Bartlett NW, Johnston SLet al., 2012, Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1, ANTIVIRAL RESEARCH, Vol: 95, Pages: 193-201, ISSN: 0166-3542

JOURNAL ARTICLE

Skevaki CL, Psarras S, Volonaki E, Pratsinis H, Spyridaki IS, Gaga M, Georgiou V, Vittorakis S, Telcian AG, Maggina P, Kletsas D, Gourgiotis D, Johnston SL, Papadopoulos NGet al., 2012, Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features., Clin Transl Allergy, Vol: 2

UNLABELLED: BACKGROUND: Human rhinoviruses, major precipitants of asthma exacerbations, induce lower airway inflammation and mediate angiogenesis. The purpose of this study was to assess the possibility that rhinoviruses may also contribute to the fibrotic component of airway remodeling. METHODS: Levels of basic fibroblast growth factor (bFGF) mRNA and protein were measured following rhinovirus infection of bronchial epithelial cells. The profibrotic effect of epithelial products was assessed by DNA synthesis and matrix metalloproteinase activity assays. Moreover, epithelial cells were exposed to supernatants from cultured peripheral blood mononuclear cells, obtained from healthy donors or atopic asthmatic subjects and subsequently infected by rhinovirus and bFGF release was estimated. bFGF was also measured in respiratory secretions from atopic asthmatic patients before and during rhinovirus-induced asthma exacerbations. RESULTS: Rhinovirus epithelial infection stimulated mRNA expression and release of bFGF, the latter being positively correlated with cell death under conditions promoting rhinovirus-induced cytotoxicity. Supernatants from infected cultures induced lung fibroblast proliferation, which was inhibited by anti-bFGF antibody, and demonstrated increased matrix metalloproteinase activity. Rhinovirus-mediated bFGF release was significantly higher in an in vitro simulation of atopic asthmatic environment and, importantly, during rhinovirus-associated asthma exacerbations. CONCLUSIONS: Rhinovirus infection induces bFGF release by airway epithelium, and stimulates stroma cell proliferation contributing to airway remodeling in asthma. Repeated rhinovirus infections may promote asthma persistence, particularly in the context of atopy; prevention of such infections may influence the natural history of asthma.

JOURNAL ARTICLE

Chawes BLK, Poorisrisak P, Johnston SL, Bisgaard Het al., 2012, Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 130, Pages: 354-+, ISSN: 0091-6749

JOURNAL ARTICLE

Bafadhel M, McKenna S, Terry S, Mistry V, Pancholi M, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CEet al., 2012, Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease A Randomized Placebo-Controlled Trial, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 48-55, ISSN: 1073-449X

JOURNAL ARTICLE

Edwards MR, Bartlett NW, Hussell T, Openshaw P, Johnston SLet al., 2012, The microbiology of asthma, NATURE REVIEWS MICROBIOLOGY, Vol: 10, Pages: 459-471, ISSN: 1740-1526

JOURNAL ARTICLE

Sykes A, Edwards MR, Macintyre J, del Rosario A, Bakhsoliani E, Trujillo-Torralbo M-B, Kon OM, Mallia P, McHale M, Johnston SLet al., 2012, Rhinovirus 16-induced IFN-alpha and IFN-beta are deficient in bronchoalveolar lavage cells in asthmatic patients, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 129, Pages: 1506-+, ISSN: 0091-6749

JOURNAL ARTICLE

Vareille M, Kieninger E, Alves MP, Kopf BS, Moeller A, Geiser T, Johnston SL, Edwards MR, Regamey Net al., 2012, Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells (Retracted article. See vol. 68, pg. 886, 2013), THORAX, Vol: 67, Pages: 517-525, ISSN: 0040-6376

JOURNAL ARTICLE

Zdrenghea MT, Johnston SL, 2012, Role of PD-L1/PD-1 in the immune response to respiratory viral infections, MICROBES AND INFECTION, Vol: 14, Pages: 495-499, ISSN: 1286-4579

JOURNAL ARTICLE

Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam Pet al., 2012, IFITM3 restricts the morbidity and mortality associated with influenza, NATURE, Vol: 484, Pages: 519-U146, ISSN: 0028-0836

JOURNAL ARTICLE

Laza-Stanca V, Message SD, Edwards MR, Parker HL, Zdrenghea MT, Kebadze T, Kon OM, Mallia P, Stanciu LA, Johnston SLet al., 2012, Correction: The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations., PLoS pathogens, Vol: 8, ISSN: 1553-7374

JOURNAL ARTICLE

Slater L, Bartlett NW, Haas JJ, Zhu J, Message SD, Walton RP, Sykes A, Dahdaleh S, Clarke DL, Belvisi MG, Kon OM, Fujita T, Jeffery PK, Johnston SL, Edwards MRet al., 2012, Correction: Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium., PLoS pathogens, Vol: 8, ISSN: 1553-7374

JOURNAL ARTICLE

Collison A, Hatchwell L, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes Jet al., 2012, ANTAGONISM OF MICRORNA-122 IS COMPARIBLE TO AZITHROMYCIN TREATMENT IN A MOUSE MODEL OF RHINOVIRUS-INDUCED EXACERBATION OF ALLERGIC AIRWAYS DISEASE, RESPIROLOGY, Vol: 17, Pages: 45-45, ISSN: 1323-7799

JOURNAL ARTICLE

Hatchwell L, Collison A, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes Jet al., 2012, TOLL-LIKE RECEPTOR 7 MEDIATES ANTI-VIRAL RESPONSES TO RHINOVIRUS WHILE SUPPRESSING EXACERBATION OF ASTHMA, RESPIROLOGY, Vol: 17, Pages: 52-52, ISSN: 1323-7799

JOURNAL ARTICLE

Hatchwell L, Collison A, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes Jet al., 2012, TRAIL REGULATES INFLAMMATORY RESPONSES TO RHINOVIRUS AND RHINOVIRUS-INDUCED EXACERBATION OF ASTHMA, RESPIROLOGY, Vol: 17, Pages: 52-52, ISSN: 1323-7799

JOURNAL ARTICLE

Kusel MMH, Kebadze T, Johnston SL, Holt PG, Sly PDet al., 2012, Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 876-882, ISSN: 0903-1936

JOURNAL ARTICLE

Singanayagam A, Joshi PV, Mallia P, Johnston SLet al., 2012, Viruses exacerbating chronic pulmonary disease: the role of immune modulation, BMC MEDICINE, Vol: 10, ISSN: 1741-7015

JOURNAL ARTICLE

Hewson CA, Haas JJ, Bartlett NW, Message SD, Laza-Stanca V, Kebadze T, Caramori G, Zhu J, Edbrooke R, Stanciu LA, Kon OM, Papi A, Jeffery PK, Edwards MR, Johnston SLet al., 2012, Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-kappa B and EGFR pathways (vol 36, pg 1425, 2010), EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 793-793, ISSN: 0903-1936

JOURNAL ARTICLE

Zdrenghea MT, Telcian AG, Laza-Stanca V, Bellettato CM, Edwards MR, Nikonova A, Khaitov MR, Azimi N, Groh V, Mallia P, Johnston SL, Stanciu LAet al., 2012, RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 712-720, ISSN: 0903-1936

JOURNAL ARTICLE

Kieninger E, Vareille M, Kopf BS, Blank F, Alves MP, Gisler FM, Latzin P, Casaulta C, Geiser T, Johnston SL, Edwards MR, Regamey Net al., 2012, Lack of an exaggerated inflammatory response on virus infection in cystic fibrosis, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 297-304, ISSN: 0903-1936

JOURNAL ARTICLE

Beasley V, Joshi PV, Singanayagam A, Molyneaux PL, Johnston SL, Mallia Pet al., 2012, Lung microbiology and exacerbations in COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 7, Pages: 555-569, ISSN: 1176-9106

JOURNAL ARTICLE

Drysdale SB, Alcazar M, Wilson T, Smith M, Zuckerman M, Wedderburn CJ, Broughton S, Rafferty GF, Johnston SL, Greenough Aet al., 2012, PANDEMIC INFLUENZA A (H1N1) VIRUS 2009 IN A PROSPECTIVELY FOLLOWED COHORT OF PREMATURELY BORN INFANTS, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 31, Pages: 91-92, ISSN: 0891-3668

JOURNAL ARTICLE

Footitt JIM, Mallia P, Trujillo-Torralbo MB, Jepson A, Johnston SLet al., 2011, DETECTION OF BACTERIA IN SPUTUM FOLLOWING EXPERIMENTAL RHINOVIRUS INFECTION IS MORE COMMON IN COPD THAN CONTROLS SUBJECTS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A10-A10, ISSN: 0040-6376

CONFERENCE PAPER

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