Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Teo:2018:10.1016/j.chom.2018.08.005,
author = {Teo, SM and Tang, HHF and Mok, D and Judd, LM and Watts, SC and Pham, K and Holt, BJ and Kusel, M and Serralha, M and Troy, N and Bochkov, YA and Grindle, K and Lemanske, RF and Johnston, SL and Gern, JE and Sly, PD and Holt, PG and Holt, KE and Inouye, M},
doi = {10.1016/j.chom.2018.08.005},
journal = {Cell Host and Microbe},
pages = {341--352.e5},
title = {Airway microbiota dynamics uncover a critical window for interplay of pathogenic bacteria and allergy in childhood respiratory disease},
url = {http://dx.doi.org/10.1016/j.chom.2018.08.005},
volume = {24},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the occurrence of acute respiratory tract illnesses (ARIs) and the nasopharyngeal microbiome (NPM) were characterized in 244 infants through their first five years of life. Through this analysis, we demonstrate that >80% of infectious events involve viral pathogens, but are accompanied by a shift in the NPM toward dominance by a small range of pathogenic bacterial genera. Unexpectedly, this change frequently precedes the detection of viral pathogens and acute symptoms. Colonization of illness-associated bacteria coupled with early allergic sensitization is associated with persistent wheeze in school-aged children, which is the hallmark of the asthma phenotype. In contrast, these bacterial genera are associated with "transient wheeze" that resolves after age 3 years in non-sensitized children. Thus, to complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children.
AU - Teo,SM
AU - Tang,HHF
AU - Mok,D
AU - Judd,LM
AU - Watts,SC
AU - Pham,K
AU - Holt,BJ
AU - Kusel,M
AU - Serralha,M
AU - Troy,N
AU - Bochkov,YA
AU - Grindle,K
AU - Lemanske,RF
AU - Johnston,SL
AU - Gern,JE
AU - Sly,PD
AU - Holt,PG
AU - Holt,KE
AU - Inouye,M
DO - 10.1016/j.chom.2018.08.005
EP - 352
PY - 2018///
SN - 1931-3128
SP - 341
TI - Airway microbiota dynamics uncover a critical window for interplay of pathogenic bacteria and allergy in childhood respiratory disease
T2 - Cell Host and Microbe
UR - http://dx.doi.org/10.1016/j.chom.2018.08.005
UR - https://www.ncbi.nlm.nih.gov/pubmed/30212648
UR - http://hdl.handle.net/10044/1/62750
VL - 24
ER -