Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Drysdale:2016:10.1007/s00431-016-2780-0,
author = {Drysdale, SB and Alcazar, M and Wilson, T and Smith, M and Zuckerman, M and Hodemaekers, HM and Janssen, R and Bont, L and Johnston, SL and Greenough, A},
doi = {10.1007/s00431-016-2780-0},
journal = {European Journal of Pediatrics},
pages = {1943--1949},
title = {Functional and genetic predisposition to rhinovirus lower respiratory tract infections in prematurely born infants},
url = {http://dx.doi.org/10.1007/s00431-016-2780-0},
volume = {175},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Term born infants are predisposed to human rhinovirus (HRV) lower respiratory tract infections (LRTI) by reduced neonatal lung function and genetic susceptibility. Our aim was to investigate whether prematurely born infants were similarly predisposed to HRV LRTIs or any other viral LRTIs. Infants born less than 36 weeks of gestational age were recruited. Prior to neonatal/maternity unit discharge, lung function (functional residual capacity by helium gas dilution and multiple breath washout, lung clearance index and compliance (Crs), and resistance (Rrs) of the respiratory system) was assessed and DNA samples assessed for eight single nucleotide polymorphisms (SNPs) in seven genes: ADAM33, IL10, MMP16 NFκB1A,SFTPC, VDR, and NOS2A. Infants were prospectively followed until 1 year corrected age. Nasopharyngeal aspirates (NPAs) were sent whenever an infant developed a LRTI and tested for 13 viruses. One hundred and thirty-nine infants were included in the analysis. Infants who developed HRV LRTIs had reduced Crs (1.6 versus 1.2 mL/cmH2O/kg, p = 0.044) at 36 weeks postmenstrual age. A SNP in the gene coding for the vitamin D receptor was associated with the development of HRV LRTIs and any viral LRTIs (p = 0.02). CONCLUSION: Prematurely born infants may have both a functional and genetic predisposition to HRV LRTIs. What is Known: • Term born infants are predisposed to rhinovirus lower respiratory tract (HRV LRTIs) infection by reduced neonatal lung function. • Term born infants requiring hospitalisation due to HRV bronchiolitis were more likely to have single nucleotide polymorphism (SNP) in the IL-10 gene. What is New: • Prematurely born infants who developed a HRV LRTI had lower C rs before maternity unit discharge. • A SNP in the gene coding for the vitamin D receptor was associated with the development of HRV LRTIs and overall respiratory viral LRTIs in prematurely born infants.
AU - Drysdale,SB
AU - Alcazar,M
AU - Wilson,T
AU - Smith,M
AU - Zuckerman,M
AU - Hodemaekers,HM
AU - Janssen,R
AU - Bont,L
AU - Johnston,SL
AU - Greenough,A
DO - 10.1007/s00431-016-2780-0
EP - 1949
PY - 2016///
SN - 1432-1076
SP - 1943
TI - Functional and genetic predisposition to rhinovirus lower respiratory tract infections in prematurely born infants
T2 - European Journal of Pediatrics
UR - http://dx.doi.org/10.1007/s00431-016-2780-0
UR - http://hdl.handle.net/10044/1/42331
VL - 175
ER -