Imperial College London

ProfessorSebastianJohnston

Faculty of MedicineNational Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)20 7594 3764s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Farne:2017:10.1016/j.coi.2017.07.017,
author = {Farne, HA and Johnston, SL},
doi = {10.1016/j.coi.2017.07.017},
journal = {Current Opinion in Immunology},
pages = {31--37},
title = {Immune mechanisms of respiratory viral infections in asthma.},
url = {http://dx.doi.org/10.1016/j.coi.2017.07.017},
volume = {48},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The more severe pathology respiratory viral infections produce in asthma sufferers is a result of a dysregulated immune response. Excess type 2 inflammation is a well-described feature of virally induced asthma exacerbations, with growing evidence that production of antiviral interferons may also be impaired. However, the mechanisms underlying these are little understood. This review summarizes the current understanding and recent discoveries of the cellular and molecular events that follow viral infections in asthma. In particular, we discuss differences in viral sensing and intracellular signalling pathways upstream of interferon induction in asthma, and the role of epithelial-derived cytokines in orchestrating type 2 immunopathology, including type 2 innate lymhpoid cells (ILC2s).
AU - Farne,HA
AU - Johnston,SL
DO - 10.1016/j.coi.2017.07.017
EP - 37
PY - 2017///
SN - 0952-7915
SP - 31
TI - Immune mechanisms of respiratory viral infections in asthma.
T2 - Current Opinion in Immunology
UR - http://dx.doi.org/10.1016/j.coi.2017.07.017
UR - http://hdl.handle.net/10044/1/51710
VL - 48
ER -