Imperial College London
Alternate

ProfessorSebastianJohnston

Faculty of Medicine, National Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)7931 376 544s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jolliffe:2018:10.1017/S000711451800209X,
author = {Jolliffe, DA and Greiller, CL and Mein, CA and Hoti, M and Bakhsoliani, E and Telcian, AG and Simpson, A and Barnes, NC and Curtin, JA and Custovic, A and Johnston, SL and Griffiths, CJ and Walton, RT and Martineau, AR},
doi = {10.1017/S000711451800209X},
journal = {British Journal of Nutrition},
pages = {891--900},
title = {Vitamin D receptor genotype influences risk of upper respiratory infection},
url = {http://dx.doi.org/10.1017/S000711451800209X},
volume = {120},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - SNP in the vitamin D receptor (VDR) gene is associated with risk of lower respiratory infections. The influence of genetic variation in the vitamin D pathway resulting in susceptibility to upper respiratory infections (URI) has not been investigated. We evaluated the influence of thirty-three SNP in eleven vitamin D pathway genes (DBP, DHCR7, RXRA, CYP2R1, CYP27B1, CYP24A1, CYP3A4, CYP27A1, LRP2, CUBN and VDR) resulting in URI risk in 725 adults in London, UK, using an additive model with adjustment for potential confounders and correction for multiple comparisons. Significant associations in this cohort were investigated in a validation cohort of 737 children in Manchester, UK. In all, three SNP in VDR (rs4334089, rs11568820 and rs7970314) and one SNP in CYP3A4 (rs2740574) were associated with risk of URI in the discovery cohort after adjusting for potential confounders and correcting for multiple comparisons (adjusted incidence rate ratio per additional minor allele ≥1·15, P for trend ≤0·030). This association was replicated for rs4334089 in the validation cohort (P for trend=0·048) but not for rs11568820, rs7970314 or rs2740574. Carriage of the minor allele of the rs4334089 SNP in VDR was associated with increased susceptibility to URI in children and adult cohorts in the United Kingdom.
AU  - Jolliffe,DA
AU  - Greiller,CL
AU  - Mein,CA
AU  - Hoti,M
AU  - Bakhsoliani,E
AU  - Telcian,AG
AU  - Simpson,A
AU  - Barnes,NC
AU  - Curtin,JA
AU  - Custovic,A
AU  - Johnston,SL
AU  - Griffiths,CJ
AU  - Walton,RT
AU  - Martineau,AR
DO  - 10.1017/S000711451800209X
EP  - 900
PY  - 2018///
SN  - 1475-2662
SP  - 891
TI  - Vitamin D receptor genotype influences risk of upper respiratory infection
T2  - British Journal of Nutrition
UR  - http://dx.doi.org/10.1017/S000711451800209X
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30132432
UR  - http://hdl.handle.net/10044/1/62274
VL  - 120
ER  -
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