Antigen Presentation Research Group (APRG)
Headed by Professor Stella C. Knight, the Antigen Presentation Research Group (APRG) operates at the interface between laboratory research and clinical medicine.
Working from a strong basic immunological science platform, the APRG studies:
- dendritic cells and dendritic cell interactions
- developing understanding of the mechanisms of human disease
- developing and testing novel therapies
Based on the Northwick Park and St. Mark's site of the North West London Hospitals NHS Trust, the symbiotic relationship between laboratory research and clinical medicine allows the APRG to provide hands on training for doctors to become scientists by gaining MD and PhD degrees.
Collaborators
Professor Michael Kamm, University of Melbourne, 2007
Guest Lectures
Macrophages, lymphocytes or dendritic cells: Which are the important players?, Falk Symposium 198 – IBD, East Meets West, Shenzhen, PR.China, 2015
Keynote Lecture "Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men"., 2nd International Symposium on E.coli and the mucosal immune system, Het Pand - Ghent University, Ghent, Belgium, 2015
Mechanisms of action of probiotics: Recent advances, Association for Clinical Microbiologists, Focus 2009 meeting, Liverpool, UK, 2014
Role of intestinal dendritic cells in shaping the mucosal immune response, 4th Cullen Symposium on Corneal and Ocular Surface Inflammation, Baylor College of Medicine, Houston, Texas, USA, 2014
Immunonutrition and human gut specific dendritic cells, Euroscicon Meeting "Understanding DCs and their ability to regulate immune responses", Welwyn Garden City, Hertfordshire, UK, 2013
Keynote lecture - "Shaping mucosal immunity via dendritic cells: Vitamins, fat and bacteria", Leibniz Institute for Age Research Retreat, Oberwiesenthal, Germany, 2013
Vitamins, fats and bugs: controlling human gut immunity via dendritic cells, Aberdeen Immunological Group - Symposium "Gut instinct - Drivers of intestinal immunity and disease", Institute of Medical Sciences, Aberdeen, 2013
Vitamins, fats and bugs: controlling human gut immunity via dendritic cells, British Society for Immunology, Regional Group Symposium on "Gut Instinct - the drivers of intestinal immunity and disease", Aberdeen, UK, 2013
Mucosal dendritic cells, Imperial College London, The cutting edge of allergy series, St Marys Hospital, London, UK, 2013
Probiotics or prebiotics, dedritic cell changes and inflammatory gut diseases, British Association for Parenteral and Enteral Nutrition (BAPEN) - Digestive Disorders Federation (DDF) joint conference., Liverpool, UK, 2012
Mucosal dendritic cells, Imperial College London, The cutting edge of allergy, St Marys Hospital, London, UK, 2012
Mucosal dendritic cells, Imperial College London, The cutting edge of allergy, St Marys Hospital, London, UK, 2011
Dendritic cells: How many subsets?, United European Gastroenterology Federation (UEGF) - Teaching activity on basic science - "Innate immunity and the gut", Cambridge, UK, 2010
Mucosal dendritic cells, Imperial College London, The cutting edge of allergy, St Marys Hospital, London UK, 2010
Bacteria, fats and migration markers - how dendritic cells control intestinal inflammation?, University of Southampton - Developmental Origins of Health and Disease Seminar Series, Southampton, UK, 2010
Prebiotics, fatty acids & vitamins: immunonutrition acting via human gut dendritic cells, Imperial College London, St Marys campus, London, UK, 2010
Fats, bugs and homing markers - How dendritic cells control human intestinal inflammation, University of Edinburgh - Cardiovascular Sciences Seminar Series, Edinburgh, UK, 2009
Fat, bugs and homing markers - How dendritic cells control human intestinal inflammation, University of Edinburgh, Cardiovascular Sciences Seminar Series, Edinburgh, UK, 2009
Probiotics, fatty acids and vitamins: immunonutrition acting via dendritic cells, Imperial College London, Hammersmith campus, London, UK, 2009
Probiotics, fatty acids and vitamins: immunonutrition acting via dendritic cells, Imperial College London, Hammersmith Campus, London, UK, 2009
Dendritic cells, inflammatory disease and the gut flora, 5th International Yakult Symposium, Amsterdam, The Netherlands, 2009
Dendritic cells, inflammatory disease and the gut flora, 5th International Yakult Symposium "The gut and more: probiotic influences beyond the gut, Amsterdam, Netherlands, 2009
Mechanism of action of probiotics: Recent advances, The Association for Clinical Microbiologists - Focus 2009 Meeting, Liverpool, UK, 2009
Mucosal dendritic cells, Imperial College London, The Cutting Edge of Allergy Programme: Basic immune cells & normal immune mechanisms, St Marys Hospital, London, 2009
Mucosal dendritic cells, Imperial College London - The Cutting Edge of Allergy Programme: Basic Immune Cells & Normal Immune Mechanisms, St. Mary's Hospital, London, UK, 2009
Specialized perinodal fat and its influence on immunity, Imperial College London - Eric Bywaters Seminar Series, Hammersmith Campus, London, UK, 2009
Specialised perinodal fat and its influence on immunity, Imperial College London, Eric Bywaters Seminar Series, Hammersmith Campus, 2009
Human gut specific dendritic cells - bugs, fat and homing markers, The University of Manchester, Immunology Club Seminar Series, School of Biological Sciences, Manchester, UK, 2008
Dendritic cells and gut inflammation, Third European Workshop on Immune-Mediated Inflammatory Diseases, The Royal Society of Medicine, London, UK, 2008
Perinodal fat - specialised to fuel and fashion immunity, Congress XXVII Giornate Endocrinologiche Pisane, Pisa, Italy, 2008
Specialisations of perinodal fat to fuel and fashion immunity, The University of Buckingham, Buckingham, UK, 2008
Dendritic cells, adipose tissue and the gut microbiota, 5th Yakult Shirota Conference, Japan, 2007
Human mucosal immunology: dendritic cells, adipose tissue and immunoregulation, Symposium: Understanding Dendritic Cells and Their Ability to Regulate Immune Responses, BioPark, Welwyn Garden City, UK, 2007
Interactions between dendritic cells, probiotic bacteria and the adipokine leptin, 1st Immunonutrition International Workshop, Valencia, Spain, 2007
Dendritic cells and perinodal adipocytes: a functional partnership, Sir William Dunn School of Pathology, Oxford, UK, 2007
Dendritic cells and perinodal adipocytes - a functional partnership, British Society for Immunology 50th Anniversary Congress, Glasgow, 2007
Dendritic cell immune competence measurement, Symposium: The Need for Standardisation of Immune Competence Assessment and Monitoring in Cancer Immunotherapy, Cardiff, UK, 2006
The role of dendritic cells, AGA-BSG International Research Meeting on the Pathogenesis of Intestinal Inflammation, Oxford, UK, 2004
Function of mucosal dendritic cells, Lille, France, 2004
Immunoregulation by dendritic cells, British Lymphoma Group Summer Meeting, Northwick Park Hospital, Harrow, UK, 2004
The antigen presenting cell in gut pathology, Gastrointestinal Pathology Symposium, St. Mark's Hospital, Harrow, UK, 2004
Dendritic cells in mucosal immunity and non-responsiveness, Ulster Immunology Group Seminar, Queen's University Belfast, Belfast, 2004
Immunoregulation by dendritic cells, Lifeline Research Seminar, University of Bristol, Bristol, UK, 2004
Dendritic cells: Will they activate or tolerize the immune system?, EMBT 2003 Meeting - Baxter Symposium on Dendritic Cells - Dendritic cells: fact or fiction?, Istanbul, Turkey, 2003
Dendritic cell functions and mucosal immunity, Barts & The London, Department of Adult and Paediatric Gastroenterology, London, UK, 2003
Dendritic cells, does it take 2 to tango?, Metchnikov Seminar Series, University of Edinburgh, Edinburgh, UK, 2003
Dendritic cell/dendritic cell interactions in primary immune responses, Moffatt Centre - Research Grand Rounds Seminar Series, Tampa, Florida, USA, 2003
Antigen Presentation, Medical Research Council - Autism Research Forum: Gut and the developing child, Commonwealth Institute, London, UK, 2002
Dendritic cells, does it take 2 to tango?, School of Biology, University of Leeds, Leeds, UK, 2002
Dendritic cell/dendritic cell interactions in primary immune responses, DFG Priority Programme: Novel Vaccination Strategies, Berlin, Germany, 2002
Dendritic cell/dendritic cell interactions in primary immune responses, NEMOD Immuntherapie AG, Max-Dellbruck Centre, Berlin, Germany, 2002
Dendritic cell/dendritic cell interactions in primary immune responses, Investigative Science Away Day, Imperial College London, London, UK, 2002
Medical Research Council - Stem Cells Meeting, London, UK, 2002
Antigen presenting cells, does it need 2 to tango?, 3rd Transfusion Medicine Conference, Magdalene College, University of Cambrige, Cambridge, UK, 2002
Interactions between dendritic cells, University of Birmingham, Edgebaston Campus, Birmingham, UK, 2002
Antigen transfer between dendritic cells, Expert meeting on dendrtiic cells in renal cell carcinoma and other tumours, Innsbruck, Austria, 2002
Immunomodulation via dendritic cells, ICRF Cancer Medicine Research Unit, Leeds, UK, 2002
Immunoregulation by dendritic cells and the effects of HIV, GlaxoSmithKline, Greenford, Middlesex, 2002
Immunoregulation by dendritic cells, 27th Annual Meeting of the Portuguese Immunology Society, Technical University of Lisbon, Lisbon, Portugal, 2001
Dendritic cell: dendritic cell interactions in primary immune responses, Nuffield Department of Surgery, Oxford, UK, 2001
Dendritic cells and HIV, Pasteur Institute Seminar, Paris, France, 2001
Dendritic cell: dendritic cell interactions, Seminar Series: The Dendritic Cell, Star Player of Immunity, Chancellor's Conference Centre, Manchester, UK, 2001
Dendritic cells and immunomodulation by retroviruses, International Symposium: Viral pathogenesis and immune control, Wurzburg, Leipzig, Germany, 2001
Retrovirally induced immunomodulation via dendritic cells, 3rd Berlin Symposium on Immunology of Infection: Dendritic Cells and Macrophages in Infectious Diseases, Berlin, Germany, 2001
Dendritic cell/dendritic cell interactions in primary immune responses, NIMR, London, UK, 2000
Immunoregulation by dendritic cells, Open University Seminar, Milton Keynes, UK, 2000
Dendritic cell/dendritic cell interactions in immunoregulation, Loyola University Chicago - Cancer Centre Basic Science Seminar Series, Illinois, USA, 2000
Dendritic cell/dendritic cell interactions, 14th European Immunology Meeting - EFIS 2000 - Dendritic Cell Section, Pozan, Poland, 2000
Dendritic cells and HIV, 2000 Institute of Human Virology Meeting, Baltimore, USA, 2000
Dendritic cells: An overview, British Society for Allergy and Clinical Immunology, Annual Meeting, Nottingham, UK, 2000
Dendritic cells/dendritic cell interactions, Hammersmith Hospital, Imperial College London, London, UK, 2000
Dendritic cells in immunobiology and pathology, Society for Toxicology, 39th Annual Meeting, Philadelphia, USA, 2000
Dendritic cells/dendritic cell interactions in primary immune responses, University of Kent, Canterbury, UK, 2000
Cytokine switching in dendritic cells, London Immunotherapy Network - Leukaemia Research Fund, London, UK, 1999
Dendritic cell: origin traffic and role in pathogenesis of HIV infection, Royal College of Pathologists - 2nd Annual CME Update in Sexually Transmitted Diseases & HIV, London, UK, 1999
Conversations between dendritic cells, 1999 Annual Meeting of the Institute of Human Virology, Baltimore, USA, 1999
Dendritic cells/dendritic cell interactions, VIII Congreso Argentino de Farmacia y Bioquinimica Industrial, Buenos Aires, Argentina, 1999
Dendritic cells in retroviral infections, Nobel Mini Symposium - Frontiers in Medicine Series: Dendritic cells from basics to vaccines, Karolinska Institutet, Stockholm, Sweden, 1999
Dendritic cells in retroviral infection, RIGHT 2nd Annual Meeting - Targeting HIV reservoirs and reconstituting the immune system, Washington DC, USA, 1999
Dendritic cells and antigen presentation, BSI East Midlands Regional Immunology Group Symposium: Immunology and Meningococcal Disease, Nottingham, UK, 1999
Dendritic cells/dendritic cell interactions, Symposium - Dendritic cell Therapy: Basic Biology to Clinical Applications, Hamburg, Germany, 1999
Antigen presentation and the cellular immune response, MIR@W Day, University of Warwick, UK, 1999
Dendritic cells/dendritic cell interactions in primary immune responses, Keele University, Staffordshire, UK, 1999