After reading Chemistry at Oxford, Simon Kroll completed undergraduate medical training at Oxford University Medical School, qualifying in 1980. His initial paediatric training was at Oxford, working under the mentorship of David Baum and Peter Tizard. After MRCP(UK), a short spell in Infectious Diseases at Great Ormond Street led to a Clinical Lectureship, and later a University Lectureship, in Richard Moxon’s Department in Oxford, where during tenure of a Lister Institute Research Fellowship he gained his first consultant post – in Paediatric Infectious Diseases – in 1988. In 1993 he moved to Imperial College and St Mary’s Hospital as Professor of Paediatrics and Molecular Infectious Diseases. He was elected FRCP in 1995, FRCPCH in 1997 and Fellow of the Academy of Medical Sciences in 2001.
From 2000 to 2008 he served two terms as a member of the UK Joint Committee on Vaccination and Immunisation (JCVI), and since 2001 has been a member of the UK Health Protection Agency’s Meningococcus Forum. He is a member of the NICE Meningitis Guideline Development Group, and chairs the Medical and Scientific Advisory Committee of The Meningitis Trust, as well as serving as a member of the Lister Institute of Preventive Medicine’s Scientific Advisory Committee.
The activities of his research group (the Molecular Infectious Diseases Group, MIDG, established with Paul Langford) have focused on the genetic and molecular basis for the virulence of bacterial pathogens, in particular Haemophilus influenzae and Neisseria meningitidis, responsible for life-threatening infections such as meningitis and septicaemia in previously healthy children. He has published over 100 papers in scientific journals on these and related topics.
et al., Structural, Functional, and Immunogenic Insights on Cu,ZnSuperoxide Dismutase Pathogenic Virulence Factors from Neisseriameningitidis and Brucella abortus., Journal of Bacteriology, ISSN:1098-5530
et al., 2018, Capsule Typing of Haemophilus influenzae by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, Emerging Infectious Diseases, Vol:24, ISSN:1080-6040, Pages:443-452
et al., 2017, Intestinal microbiota in infants at high risk for allergy: Effects of prebiotics and role in eczema development., J Allergy Clin Immunol
Li M-S, Langford PR, Kroll JS, 2017, Inactivation of NMB0419, Encoding a Sel1-Like Repeat (SLR) Protein, in Neisseria meningitidis Is Associated with Differential Expression of Genes Belonging to the Fur Regulon and Reduced Intraepithelial Replication, Infection and Immunity, Vol:85, ISSN:0019-9567
et al., 2017, Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis, Microbiome, Vol:5, ISSN:2049-2618