Imperial College London
Portrait Picture

ProfessorJ SimonKroll

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor,Paediatrics&Molecular Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3695s.kroll

 
 
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Assistant

 

Dr Robert Boyle +44 (0)20 7594 3990

 
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Location

 

245Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Powell:2019:10.1016/j.ebiom.2019.07.034,
author = {Powell, E and Fontanella, S and Boakes, E and Belgrave, D and Shaw, A and Cornwell, E and Fernandez-Crespo, R and Fink, C and Custovic, A and Kroll, JS},
doi = {10.1016/j.ebiom.2019.07.034},
journal = {EBioMedicine},
pages = {486--498},
title = {Temporal association of the development of oropharyngeal microbiota with early life wheeze in a population-based birth cohort},
url = {http://dx.doi.org/10.1016/j.ebiom.2019.07.034},
volume = {46},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background A critical window in infancy has been proposed, during which the microbiota may affect subsequent health. The longitudinal development of the oropharyngeal microbiota is under-studied and may be associated with early-life wheeze. We aimed to investigate the temporal association of the development of the oropharyngeal microbiota with early-life wheeze.Methods A population-based birth cohort based in London, UK was followed for 24 months. We collected oropharyngeal swabs at six time-points. Microbiota was determined using sequencing of the V3-V5 region of the 16S rRNA-encoding gene. Medical records were reviewed for the outcome of doctor diagnosed wheeze. We used a time-varying model to investigate the temporal association between the development of microbiota and doctor-diagnosed wheeze. Findings 159 participants completed the study to 24 months and for 98 there was complete sequencing data at all timepoints and outcome data. Of these, 26 had doctor-diagnosed wheeze. We observed significant increase in the abundance of Neisseria between 9 and 24 months in children who developed wheeze (p=0003), while in those without wheezing there was a significant increment in the abundance of Granulicatella (p=0 012) between 9 and 12 months, and of Prevotella (p=0 018) after 18 months. Interpretation A temporal association between the respiratory commensal Granulicatella and also Prevotella with wheeze (negative), and between Neisseria and wheeze (positive) was identified in infants prior to one year of age. This adds to evidence for the proposed role of the microbiota in the development of wheeze.
AU  - Powell,E
AU  - Fontanella,S
AU  - Boakes,E
AU  - Belgrave,D
AU  - Shaw,A
AU  - Cornwell,E
AU  - Fernandez-Crespo,R
AU  - Fink,C
AU  - Custovic,A
AU  - Kroll,JS
DO  - 10.1016/j.ebiom.2019.07.034
EP  - 498
PY  - 2019///
SN  - 2352-3964
SP  - 486
TI  - Temporal association of the development of oropharyngeal microbiota with early life wheeze in a population-based birth cohort
T2  - EBioMedicine
UR  - http://dx.doi.org/10.1016/j.ebiom.2019.07.034
UR  - http://hdl.handle.net/10044/1/71946
VL  - 46
ER  -
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