Imperial College London
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ProfessorJ SimonKroll

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor,Paediatrics&Molecular Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3695s.kroll

 
 
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Assistant

 

Dr Robert Boyle +44 (0)20 7594 3990

 
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Location

 

245Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Strouts:2012,
author = {Strouts, FR and Power, P and Croucher, NJ and Corton, N and van, Tonder A and Quail, MA and Langford, PR and Hudson, MJ and Parkhill, J and Kroll, JS and Bentley, SD},
journal = {Emerging Infectious Diseases},
pages = {449--457},
title = {Lineage-specific Virulence Determinants of Haemophilus influenzae Biogroup aegyptius},
url = {http://hdl.handle.net/10044/1/19645},
volume = {18},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.
AU  - Strouts,FR
AU  - Power,P
AU  - Croucher,NJ
AU  - Corton,N
AU  - van,Tonder A
AU  - Quail,MA
AU  - Langford,PR
AU  - Hudson,MJ
AU  - Parkhill,J
AU  - Kroll,JS
AU  - Bentley,SD
EP  - 457
PY  - 2012///
SP  - 449
TI  - Lineage-specific Virulence Determinants of Haemophilus influenzae Biogroup aegyptius
T2  - Emerging Infectious Diseases
UR  - http://hdl.handle.net/10044/1/19645
VL  - 18
ER  -
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